{
 "meta": {
  "name": "Tendground medication heat-warning label index",
  "version": "1.0",
  "date_checked": "2026-10-04",
  "rows": 83,
  "source": "U.S. FDA drug labels via openFDA (api.fda.gov/drug/label.json), linked to DailyMed",
  "license": "CC BY 4.0",
  "categories": [
   "heat_or_thermoregulation",
   "decreased_sweating",
   "sweating",
   "hyperthermia",
   "dehydration",
   "orthostatic_hypotension",
   "photosensitivity"
  ],
  "terms": {
   "heat_or_thermoregulation": "radiant heat|heat sources?|hot weather|extreme heat|heat exposure|exposure to heat|exposed to (?:extreme )?heat|high (?:environmental |ambient )?temperatures?|temperature extremes|extremes? of temperature|hot environments?|overheat(?:ing|ed)?|heat[- ]related|heat illness|heat intolerance|heat prostration|core body temperature|reduce core|temperature regulation|thermoregulat\\w*|\\bsaunas?\\b|hot tubs?|hot baths?|whirlpools?|heating pads?|electric blankets?|heat lamps?|heated water ?beds?|sunbathing|external heat|direct heat",
   "decreased_sweating": "oligohidrosis|anhidrosis|hypohidrosis|decreas\\w* sweating|reduc\\w* sweating|inability to sweat|lack of sweating|absence of sweating|decrease(?:d)? (?:in )?(?:perspiration|sweating)",
   "sweating": "hyperhidrosis|(?<!decreased )(?<!reduced )(?<!of )\\bsweating\\b(?! decreased)|increased sweating|excessive sweating|diaphoresis|\\bsweats\\b|perspiration",
   "hyperthermia": "hyperthermia|heat ?stroke|heat exhaustion|hyperpyrexia|elevated body temperature|increased body temperature|body temperature (?:elevation|increase)",
   "dehydration": "dehydrat\\w*|volume depletion|fluid loss",
   "orthostatic_hypotension": "orthostatic hypotension|postural hypotension|orthostatic (?:effects|signs|symptoms|changes|dizziness|regulation)|orthostatic,? decreases|dizziness (?:on|upon|when) standing|stand(?:ing)? up (?:too )?(?:quickly|fast)",
   "photosensitivity": "photosensitiv\\w*|photosensitization|phototoxic\\w*|sunburn|sunlight|ultraviolet|sun exposure|exposure to (?:the )?sun|tanning (?:beds?|booths?)|sunlamps?|sun lamps?"
  },
  "contexts": {
   "direct": [
    "warning",
    "side effect",
    "patient advice",
    "directions for use",
    "pharmacology",
    "heat exposure or thermoregulation"
   ],
   "indirect": [
    "serotonin syndrome symptom",
    "neuroleptic malignant syndrome symptom",
    "low blood sugar symptom",
    "overdose",
    "too much thyroid hormone",
    "withdrawal",
    "misuse",
    "drug interaction"
   ],
   "skipped": [
    "reduced sweating",
    "describes the condition treated"
   ]
  },
  "heat_kinds": {
   "patch_heat": "Keep heat off the patch",
   "thermoregulation": "Body temperature regulation",
   "less_sweating": "Less sweating, more risk of overheating",
   "hot_weather": "Hot weather named as a risk",
   "heat_intolerance": "Heat intolerance as a sign of too much thyroid hormone",
   "drug_or_device": "Heat or a sauna affects the drug or how it is delivered"
  },
  "sauna_terms": "\\bsaunas?\\b|hot tubs?|whirlpools?|hot baths?|steam rooms?|jacuzzi",
  "label_selection": "One label per medicine from the openFDA drug label endpoint (which mirrors DailyMed SPL): the most recently updated label for the exact product, from the manufacturer or brand owner rather than a repackager where available; for generics, the immediate-release tablet where one exists. Celebrex: the newest label was a repackager's (NDC labeler 63187), so the brand owner's (Viatris) label is used.",
  "excluded_sections": "storage and handling, how supplied, package label, product description, ingredient lists, purpose, references, clinical studies, unclassified sections",
  "manual_review": [
   "Synthroid / sweating: context set by hand to 'too much thyroid hormone'",
   "Synthroid / heat_or_thermoregulation: context set by hand to 'too much thyroid hormone'",
   "Neurontin / sweating: context set by hand to 'withdrawal'",
   "Claravis / photosensitivity: excerpt chosen by hand (a fuller verbatim passage than the first term match)",
   "lithium carbonate / dehydration: excerpt chosen by hand (a fuller verbatim passage than the first term match)",
   "Neurontin / sweating: excerpt chosen by hand (a fuller verbatim passage than the first term match)",
   "Topamax / decreased_sweating: excerpt chosen by hand (a fuller verbatim passage than the first term match)",
   "Topamax / hyperthermia: excerpt chosen by hand (a fuller verbatim passage than the first term match)",
   "Xulane / heat_or_thermoregulation: excerpt chosen by hand (a fuller verbatim passage than the first term match)",
   "Humalog / heat_or_thermoregulation: excerpt chosen by hand (a fuller verbatim passage than the first term match)",
   "Synthroid / heat_or_thermoregulation: excerpt chosen by hand (a fuller verbatim passage than the first term match)",
   "Synthroid / sweating: excerpt chosen by hand (a fuller verbatim passage than the first term match)",
   "Seroquel / hyperthermia: excerpt chosen by hand (a fuller verbatim passage than the first term match)",
   "Seroquel XR / hyperthermia: excerpt chosen by hand (a fuller verbatim passage than the first term match)",
   "heat_kind: assigned by hand from each label's heat excerpt"
  ],
  "notes": "Term matching over label text; a blank is not a safety claim. Excerpts are verbatim; '…' marks omitted text. Not medical advice.",
  "url": "https://www.tendground.com/wellness/medication-heat-label-index",
  "csv": "https://www.tendground.com/data/medication-heat-label-index.csv",
  "license_url": "https://creativecommons.org/licenses/by/4.0/",
  "citation": "Tendground. (2026). Medication heat-warning label index (Version 1.0) [Data set]. FDA drug labels checked 2026-10-04. https://www.tendground.com/wellness/medication-heat-label-index"
 },
 "rows": [
  {
   "drug": "Adderall",
   "generic": "amphetamine and dextroamphetamine",
   "class": "Stimulant (ADHD)",
   "group": "ADHD stimulants",
   "label_title": "Adderall / DEXTROAMPHETAMINE SACCHARATE, AMPHETAMINE ASPARTATE, DEXTROAMPHETAMINE SULFATE, AND AMPHETAMINE SULFATE",
   "label_type": "Rx",
   "set_id": "f22635fe-821d-4cde-aa12-419f8b53db81",
   "label_version": "21",
   "label_effective": "2024-05-29",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=f22635fe-821d-4cde-aa12-419f8b53db81",
   "guide": "https://www.tendground.com/journal/wellness-on-adhd-stimulants-what-is-safe",
   "heat_or_thermoregulation": false,
   "decreased_sweating": false,
   "sweating": true,
   "sweating_direct": false,
   "sweating_context": "serotonin syndrome symptom",
   "sweating_section": "Warnings",
   "sweating_excerpt": "…status changes (e.g., agitation, hallucinations, delirium, and coma), autonomic instability (e.g., tachycardia, labile blood pressure, dizziness, diaphoresis, flushing, hyperthermia), neuromuscular symptoms (e.g., tremor, rigidity, myoclonus, hyperreflexia, incoordination), seizures, and/or…",
   "hyperthermia": true,
   "hyperthermia_direct": false,
   "hyperthermia_context": "serotonin syndrome symptom",
   "hyperthermia_section": "Warnings",
   "hyperthermia_excerpt": "…agitation, hallucinations, delirium, and coma), autonomic instability (e.g., tachycardia, labile blood pressure, dizziness, diaphoresis, flushing, hyperthermia), neuromuscular symptoms (e.g., tremor, rigidity, myoclonus, hyperreflexia, incoordination), seizures, and/or gastrointestinal symptoms (e.g.,…",
   "dehydration": false,
   "orthostatic_hypotension": false,
   "photosensitivity": false,
   "heat_kind": null,
   "names_sauna_or_hot_tub": false,
   "storage": "Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]."
  },
  {
   "drug": "Adderall XR",
   "generic": "amphetamine and dextroamphetamine, extended release",
   "class": "Stimulant (ADHD)",
   "group": "ADHD stimulants",
   "label_title": "Adderall XR / DEXTROAMPHETAMINE SULFATE, DEXTROAMPHETAMINE SACCHARATE, AMPHETAMINE SULFATE AND AMPHETAMINE ASPARTATE",
   "label_type": "Rx",
   "set_id": "aff45863-ffe1-4d4f-8acf-c7081512a6c0",
   "label_version": "38",
   "label_effective": "2026-04-30",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=aff45863-ffe1-4d4f-8acf-c7081512a6c0",
   "guide": "https://www.tendground.com/journal/wellness-on-adhd-stimulants-what-is-safe",
   "heat_or_thermoregulation": false,
   "decreased_sweating": false,
   "sweating": true,
   "sweating_direct": true,
   "sweating_context": "side effect",
   "sweating_section": "Adverse reactions",
   "sweating_excerpt": "…tooth disorder (e.g., teeth clenching, tooth infection), emotional lability, libido decreased, somnolence, speech disorder (e.g., stuttering, excessive speech), palpitation, twitching, dyspnea, sweating, dysmenorrhea, and impotence.",
   "hyperthermia": true,
   "hyperthermia_direct": false,
   "hyperthermia_context": "serotonin syndrome symptom",
   "hyperthermia_section": "Warnings and precautions",
   "hyperthermia_excerpt": "…agitation, hallucinations, delirium, and coma), autonomic instability (e.g., tachycardia, labile blood pressure, dizziness, diaphoresis, flushing, hyperthermia), neuromuscular symptoms (e.g., tremor, rigidity, myoclonus, hyperreflexia, incoordination), seizures, and/or gastrointestinal symptoms (e.g.,…",
   "dehydration": false,
   "orthostatic_hypotension": false,
   "photosensitivity": true,
   "photosensitivity_direct": true,
   "photosensitivity_context": "side effect",
   "photosensitivity_section": "Adverse reactions",
   "photosensitivity_excerpt": "…were reported by 2 to 4% of adult patients receiving ADDERALL XR with a higher incidence than patients receiving placebo in this study: infection, photosensitivity reaction, constipation, tooth disorder (e.g., teeth clenching, tooth infection), emotional lability, libido decreased, somnolence, speech disorder…",
   "heat_kind": null,
   "names_sauna_or_hot_tub": false,
   "storage": "Store at room temperature, 20 to 25ºC (68 to 77ºF)."
  },
  {
   "drug": "Vyvanse",
   "generic": "lisdexamfetamine",
   "class": "Stimulant (ADHD)",
   "group": "ADHD stimulants",
   "label_title": "Vyvanse / LISDEXAMFETAMINE DIMESYLATE",
   "label_type": "Rx",
   "set_id": "704e4378-ca83-445c-8b45-3cfa51c1ecad",
   "label_version": "81",
   "label_effective": "2026-04-30",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=704e4378-ca83-445c-8b45-3cfa51c1ecad",
   "guide": "https://www.tendground.com/journal/wellness-on-adhd-stimulants-what-is-safe",
   "heat_or_thermoregulation": false,
   "decreased_sweating": false,
   "sweating": true,
   "sweating_direct": true,
   "sweating_context": "side effect",
   "sweating_section": "Adverse reactions",
   "sweating_excerpt": "…8% Dry Mouth 26% 3% Diarrhea 7% 0% Nausea 7% 0% Anxiety 6% 0% Anorexia 5% 0% Feeling Jittery 4% 0% Agitation 3% 0% Increased Blood Pressure 3% 0% Hyperhidrosis 3% 0% Restlessness 3% 0% Decreased Weight 3% 0% Dyspnea 2% 0% Increased Heart Rate 2% 0% Tremor 2% 0% Palpitations 2% 0% In addition, in the adult…",
   "hyperthermia": true,
   "hyperthermia_direct": false,
   "hyperthermia_context": "serotonin syndrome symptom",
   "hyperthermia_section": "Warnings and precautions",
   "hyperthermia_excerpt": "…agitation, hallucinations, delirium, and coma), autonomic instability (e.g., tachycardia, labile blood pressure, dizziness, diaphoresis, flushing, hyperthermia), neuromuscular symptoms (e.g., tremor, rigidity, myoclonus, hyperreflexia, incoordination), seizures, and/or gastrointestinal symptoms (e.g.,…",
   "dehydration": false,
   "orthostatic_hypotension": false,
   "photosensitivity": false,
   "heat_kind": null,
   "names_sauna_or_hot_tub": false,
   "storage": "Store at room temperature, 20°C to 25°C (68°F to 77°F)."
  },
  {
   "drug": "Ritalin",
   "generic": "methylphenidate",
   "class": "Stimulant (ADHD)",
   "group": "ADHD stimulants",
   "label_title": "Ritalin / methylphenidate",
   "label_type": "Rx",
   "set_id": "c0bf0835-6a2f-4067-a158-8b86c4b0668a",
   "label_version": "32",
   "label_effective": "2025-02-05",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=c0bf0835-6a2f-4067-a158-8b86c4b0668a",
   "guide": "https://www.tendground.com/journal/wellness-on-adhd-stimulants-what-is-safe",
   "heat_or_thermoregulation": false,
   "decreased_sweating": false,
   "sweating": true,
   "sweating_direct": true,
   "sweating_context": "side effect",
   "sweating_section": "Adverse reactions",
   "sweating_excerpt": "…Disorders: abnormal liver function, ranging from transaminase elevation to severe hepatic injury Skin and Subcutaneous Tissue Disorders: hyperhidrosis, pruritus, urticaria, exfoliative dermatitis, scalp hair loss, erythema multiforme rash, thrombocytopenic purpura Musculoskeletal and Connective…",
   "hyperthermia": true,
   "hyperthermia_direct": true,
   "hyperthermia_context": "side effect",
   "hyperthermia_section": "Adverse reactions",
   "hyperthermia_excerpt": "…myalgia, muscle twitching Renal and Urinary Disorders: hematuria Reproductive System and Breast Disorders: gynecomastia General Disorders: fatigue, hyperpyrexia Urogenital Disorders: priapism Common adverse reactions: tachycardia, palpitations, headache, insomnia, anxiety, hyperhidrosis, weight loss,…",
   "dehydration": false,
   "orthostatic_hypotension": false,
   "photosensitivity": false,
   "heat_kind": null,
   "names_sauna_or_hot_tub": false,
   "storage": "Store at 20°C to 25°C (68°F to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F) [see USP controlled room temperature]."
  },
  {
   "drug": "Concerta",
   "generic": "methylphenidate, extended release",
   "class": "Stimulant (ADHD)",
   "group": "ADHD stimulants",
   "label_title": "CONCERTA / METHYLPHENIDATE HYDROCHLORIDE",
   "label_type": "Rx",
   "set_id": "1a88218c-5b18-4220-8f56-526de1a276cd",
   "label_version": "30",
   "label_effective": "2026-04-20",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=1a88218c-5b18-4220-8f56-526de1a276cd",
   "guide": "https://www.tendground.com/journal/wellness-on-adhd-stimulants-what-is-safe",
   "heat_or_thermoregulation": false,
   "decreased_sweating": false,
   "sweating": true,
   "sweating_direct": true,
   "sweating_context": "side effect",
   "sweating_section": "Adverse reactions",
   "sweating_excerpt": "( 6.1 ) Adults up to 65 years of age: decreased appetite, headache, dry mouth, nausea, insomnia, anxiety, dizziness, weight decreased, irritability, tachycardia, and hyperhidrosis.",
   "hyperthermia": true,
   "hyperthermia_direct": true,
   "hyperthermia_context": "side effect",
   "hyperthermia_section": "Adverse reactions",
   "hyperthermia_excerpt": "…: Diplopia, Increased intraocular pressure, Mydriasis General Disorders and Administration Site Conditions : Chest pain, Drug effect decreased, Hyperpyrexia Hepatobiliary Disorders : Hepatocellular injury, Acute hepatic failure, Blood bilirubin increased Immune System Disorders : Hypersensitivity…",
   "dehydration": false,
   "orthostatic_hypotension": false,
   "photosensitivity": false,
   "heat_kind": null,
   "names_sauna_or_hot_tub": false,
   "storage": "Store at 25 °C (77 °F); excursions permitted to 15–30 °C (59–86 °F) [see USP Controlled Room Temperature] ."
  },
  {
   "drug": "Daytrana",
   "generic": "methylphenidate transdermal patch",
   "class": "Stimulant (ADHD), patch",
   "group": "ADHD stimulants",
   "label_title": "Daytrana / METHYLPHENIDATE",
   "label_type": "Rx",
   "set_id": "2c312c31-3198-4775-91ab-294e0b4b9e7f",
   "label_version": "29",
   "label_effective": "2025-09-01",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=2c312c31-3198-4775-91ab-294e0b4b9e7f",
   "guide": "https://www.tendground.com/journal/sauna-and-hot-tub-with-a-medicated-patch-what-is-safe",
   "heat_or_thermoregulation": true,
   "heat_or_thermoregulation_direct": true,
   "heat_or_thermoregulation_context": "warning",
   "heat_or_thermoregulation_section": "Warnings and precautions",
   "heat_or_thermoregulation_excerpt": "( 5.10 ) External Heat: Patients should be advised to avoid exposing the DAYTRANA application site to direct external heat sources.",
   "decreased_sweating": false,
   "sweating": true,
   "sweating_direct": false,
   "sweating_context": "misuse",
   "sweating_section": "Drug abuse and dependence",
   "sweating_excerpt": "Misuse and abuse of methylphenidate may cause increased heart rate, respiratory rate, or blood pressure; sweating; dilated pupils; hyperactivity; restlessness; insomnia; decreased appetite; loss of coordination; tremors; flushed skin; vomiting; and/or abdominal pain.",
   "hyperthermia": true,
   "hyperthermia_direct": false,
   "hyperthermia_context": "overdose",
   "hyperthermia_section": "Overdosage",
   "hyperthermia_excerpt": "Life-threatening hyperthermia (temperatures greater than 104°F) and rhabdomyolysis may develop.",
   "dehydration": false,
   "orthostatic_hypotension": false,
   "photosensitivity": false,
   "heat_kind": "patch_heat",
   "names_sauna_or_hot_tub": false,
   "storage": "Store at 25° C (77° F); excursions permitted to 15-30° C (59-86° F) [see USP Controlled Room Temperature]."
  },
  {
   "drug": "Zoloft",
   "generic": "sertraline",
   "class": "Antidepressant (SSRI)",
   "group": "Antidepressants and lithium",
   "label_title": "Zoloft / SERTRALINE HYDROCHLORIDE",
   "label_type": "Rx",
   "set_id": "fda754f6-d0f3-4dce-a17a-927d64f912f7",
   "label_version": "7",
   "label_effective": "2023-08-08",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=fda754f6-d0f3-4dce-a17a-927d64f912f7",
   "guide": "https://www.tendground.com/journal/wellness-on-antidepressants-what-is-safe",
   "heat_or_thermoregulation": false,
   "decreased_sweating": false,
   "sweating": true,
   "sweating_direct": true,
   "sweating_context": "side effect",
   "sweating_section": "Adverse reactions",
   "sweating_excerpt": "…adverse reactions (≥5% and twice placebo) in pooled placebo-controlled MDD, OCD, PD, PTSD, SAD and PMDD clinical trials were nausea, diarrhea/loose stool, tremor, dyspepsia, decreased appetite, hyperhidrosis, ejaculation failure, and decreased libido.",
   "hyperthermia": true,
   "hyperthermia_direct": false,
   "hyperthermia_context": "serotonin syndrome symptom",
   "hyperthermia_section": "Warnings and precautions",
   "hyperthermia_excerpt": "…agitation, hallucinations, delirium, and coma), autonomic instability (e.g., tachycardia, labile blood pressure, dizziness, diaphoresis, flushing, hyperthermia), neuromuscular symptoms (e.g., tremor, rigidity, myoclonus, hyperreflexia, incoordination), seizures, and gastrointestinal symptoms (e.g., nausea,…",
   "dehydration": false,
   "orthostatic_hypotension": false,
   "photosensitivity": true,
   "photosensitivity_direct": true,
   "photosensitivity_context": "side effect",
   "photosensitivity_section": "Adverse reactions",
   "photosensitivity_excerpt": "…thoracic and mediastinal disorders - pulmonary hypertension, eosinophilic pneumonia, anosmia, hyposmia Skin and subcutaneous tissue disorders - photosensitivity skin reaction and other severe cutaneous reactions, which potentially can be fatal, such as Stevens-Johnson Syndrome (SJS) and toxic epidermal…",
   "heat_kind": null,
   "names_sauna_or_hot_tub": false,
   "storage": "Store ZOLOFT at 20°C to 25°C (68°F to 77°F); excursions permitted to 15°C to 30°C (59°F to 86°F) [See USP Controlled Room Temperature]."
  },
  {
   "drug": "Lexapro",
   "generic": "escitalopram",
   "class": "Antidepressant (SSRI)",
   "group": "Antidepressants and lithium",
   "label_title": "Lexapro / escitalopram",
   "label_type": "Rx",
   "set_id": "4a08b6cf-7ba0-54a9-14e0-a6e8d1e4854e",
   "label_version": "7",
   "label_effective": "2024-01-15",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=4a08b6cf-7ba0-54a9-14e0-a6e8d1e4854e",
   "guide": "https://www.tendground.com/journal/wellness-on-antidepressants-what-is-safe",
   "heat_or_thermoregulation": false,
   "decreased_sweating": false,
   "sweating": true,
   "sweating_direct": true,
   "sweating_context": "side effect",
   "sweating_section": "Adverse reactions",
   "sweating_excerpt": "6 ADVERSE REACTIONS Most commonly observed adverse reactions (incidence ≥ 5% and at least twice the incidence of placebo patients) are: insomnia, ejaculation disorder (primarily ejaculatory delay), nausea, sweating increased, fatigue and somnolence, decreased libido, and anorgasmia ( 6.1 ).",
   "hyperthermia": true,
   "hyperthermia_direct": false,
   "hyperthermia_context": "serotonin syndrome symptom",
   "hyperthermia_section": "Warnings and precautions",
   "hyperthermia_excerpt": "…agitation, hallucinations, delirium, and coma), autonomic instability (e.g., tachycardia, labile blood pressure, dizziness, diaphoresis, flushing, hyperthermia), neuromuscular symptoms (e.g., tremor, rigidity, myoclonus, hyperreflexia, incoordination) seizures, and/or gastrointestinal symptoms (e.g.,…",
   "dehydration": false,
   "orthostatic_hypotension": true,
   "orthostatic_hypotension_direct": true,
   "orthostatic_hypotension_context": "side effect",
   "orthostatic_hypotension_section": "Adverse reactions",
   "orthostatic_hypotension_excerpt": "Vascular Disorders: deep vein thrombosis, flushing, hypertensive crisis, hypotension, orthostatic hypotension, phlebitis, thrombosis.",
   "photosensitivity": true,
   "photosensitivity_direct": true,
   "photosensitivity_context": "side effect",
   "photosensitivity_section": "Adverse reactions",
   "photosensitivity_excerpt": "Skin and Subcutaneous Tissue Disorders: alopecia, angioedema, dermatitis, ecchymosis, erythema multiforme, photosensitivity reaction, Stevens Johnson Syndrome, toxic epidermal necrolysis, urticaria.",
   "heat_kind": null,
   "names_sauna_or_hot_tub": false,
   "storage": null
  },
  {
   "drug": "Prozac",
   "generic": "fluoxetine",
   "class": "Antidepressant (SSRI)",
   "group": "Antidepressants and lithium",
   "label_title": "Prozac / FLUOXETINE HYDROCHLORIDE",
   "label_type": "Rx",
   "set_id": "c88f33ed-6dfb-4c5e-bc01-d8e36dd97299",
   "label_version": "59",
   "label_effective": "2026-01-08",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=c88f33ed-6dfb-4c5e-bc01-d8e36dd97299",
   "guide": "https://www.tendground.com/journal/wellness-on-antidepressants-what-is-safe",
   "heat_or_thermoregulation": false,
   "decreased_sweating": false,
   "sweating": true,
   "sweating_direct": true,
   "sweating_context": "side effect",
   "sweating_section": "Adverse reactions",
   "sweating_excerpt": "…diarrhea, dry mouth, dyspepsia, flu syndrome, impotence, insomnia, libido decreased, nausea, nervousness, pharyngitis, rash, sinusitis, somnolence, sweating, tremor, vasodilatation, and yawn ( 6.1 ) PROZAC and olanzapine in combination – Also refer to the Adverse Reactions section of the package insert…",
   "hyperthermia": true,
   "hyperthermia_direct": false,
   "hyperthermia_context": "serotonin syndrome symptom",
   "hyperthermia_section": "Warnings and precautions",
   "hyperthermia_excerpt": "…agitation, hallucinations, delirium, and coma), autonomic instability (e.g., tachycardia, labile blood pressure, dizziness, diaphoresis, flushing, hyperthermia), neuromuscular symptoms (e.g., tremor, rigidity, myoclonus, hyperreflexia, incoordination), seizures, and/or gastrointestinal symptoms (e.g.,…",
   "dehydration": false,
   "orthostatic_hypotension": false,
   "photosensitivity": true,
   "photosensitivity_direct": true,
   "photosensitivity_context": "side effect",
   "photosensitivity_section": "Adverse reactions",
   "photosensitivity_excerpt": "Body as a Whole — Frequent: chills; Infrequent: suicide attempt; Rare: acute abdominal syndrome, photosensitivity reaction.",
   "heat_kind": null,
   "names_sauna_or_hot_tub": false,
   "storage": "Store at Controlled Room Temperature, 15° to 30°C (59° to 86°F)."
  },
  {
   "drug": "Effexor XR",
   "generic": "venlafaxine",
   "class": "Antidepressant (SNRI)",
   "group": "Antidepressants and lithium",
   "label_title": "Effexor XR / VENLAFAXINE HYDROCHLORIDE",
   "label_type": "Rx",
   "set_id": "c848a5d8-ba94-4c84-80e3-0bf35fb8e32e",
   "label_version": "7",
   "label_effective": "2023-08-15",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=c848a5d8-ba94-4c84-80e3-0bf35fb8e32e",
   "guide": "https://www.tendground.com/journal/wellness-on-antidepressants-what-is-safe",
   "heat_or_thermoregulation": false,
   "decreased_sweating": false,
   "sweating": true,
   "sweating_direct": true,
   "sweating_context": "side effect",
   "sweating_section": "Adverse reactions",
   "sweating_excerpt": "Sexual Dysfunction [see Warnings and Precautions (5.13) ] Most common adverse reactions (incidence ≥5% and at least twice the rate of placebo): nausea, somnolence, dry mouth, sweating, abnormal ejaculation, anorexia, constipation, impotence (men), and libido decreased ( 6.1 ).",
   "hyperthermia": true,
   "hyperthermia_direct": false,
   "hyperthermia_context": "serotonin syndrome symptom",
   "hyperthermia_section": "Warnings and precautions",
   "hyperthermia_excerpt": "…agitation, hallucinations, delirium, coma), autonomic instability (e.g., tachycardia, labile blood pressure, dizziness, diaphoresis, flushing, hyperthermia), neuromuscular symptoms (e.g., tremor, rigidity, myoclonus, hyperreflexia, incoordination), seizures, and gastrointestinal symptoms (e.g., nausea,…",
   "dehydration": false,
   "orthostatic_hypotension": true,
   "orthostatic_hypotension_direct": true,
   "orthostatic_hypotension_context": "side effect",
   "orthostatic_hypotension_section": "Adverse reactions",
   "orthostatic_hypotension_excerpt": "…(men) 5.3 1.0 Other Adverse Reactions Observed in Clinical Studies Body as a Whole – Photosensitivity reaction, chills Cardiovascular System – Postural hypotension, syncope, hypotension, tachycardia Digestive System – Gastrointestinal hemorrhage [see Warnings and Precautions (5.4) ] , bruxism Hemic/Lymphatic…",
   "photosensitivity": true,
   "photosensitivity_direct": true,
   "photosensitivity_context": "side effect",
   "photosensitivity_section": "Adverse reactions",
   "photosensitivity_excerpt": "…(Effexor XR, n = 2,118; placebo, n = 1,274) 2.0 0.2 Impotence (men) 5.3 1.0 Other Adverse Reactions Observed in Clinical Studies Body as a Whole – Photosensitivity reaction, chills Cardiovascular System – Postural hypotension, syncope, hypotension, tachycardia Digestive System – Gastrointestinal hemorrhage [see…",
   "heat_kind": null,
   "names_sauna_or_hot_tub": false,
   "storage": "Store at controlled room temperature, 20° to 25°C (68° to 77°F)."
  },
  {
   "drug": "Cymbalta",
   "generic": "duloxetine",
   "class": "Antidepressant (SNRI)",
   "group": "Antidepressants and lithium",
   "label_title": "Cymbalta / duloxetine",
   "label_type": "Rx",
   "set_id": "2f7d4d67-10c1-4bf4-a7f2-c185fbad64ba",
   "label_version": "90",
   "label_effective": "2025-07-21",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=2f7d4d67-10c1-4bf4-a7f2-c185fbad64ba",
   "guide": null,
   "heat_or_thermoregulation": false,
   "decreased_sweating": false,
   "sweating": true,
   "sweating_direct": true,
   "sweating_context": "side effect",
   "sweating_section": "Adverse reactions",
   "sweating_excerpt": "…and at least twice the incidence of placebo-treated patients): ( 6.1 ) Adults : nausea, dry mouth, somnolence, constipation, decreased appetite, and hyperhidrosis Pediatric Patients : decreased weight, decreased appetite, nausea, vomiting, fatigue, and diarrhea To report SUSPECTED ADVERSE REACTIONS, contact…",
   "hyperthermia": true,
   "hyperthermia_direct": false,
   "hyperthermia_context": "serotonin syndrome symptom",
   "hyperthermia_section": "Warnings and precautions",
   "hyperthermia_excerpt": "…agitation, hallucinations, delirium, and coma), autonomic instability (e.g., tachycardia, labile blood pressure, dizziness, diaphoresis, flushing, hyperthermia), neuromuscular symptoms (e.g., tremor, rigidity, myoclonus, hyperreflexia, incoordination), seizures, and gastrointestinal symptoms (e.g., nausea,…",
   "dehydration": true,
   "dehydration_direct": true,
   "dehydration_context": "side effect",
   "dehydration_section": "Adverse reactions",
   "dehydration_excerpt": "Metabolism and Nutrition Disorders — Infrequent: dehydration and hyperlipidemia; Rare: dyslipidemia.",
   "orthostatic_hypotension": true,
   "orthostatic_hypotension_direct": true,
   "orthostatic_hypotension_context": "warning",
   "orthostatic_hypotension_section": "Warnings and precautions",
   "orthostatic_hypotension_excerpt": "5.3 Orthostatic Hypotension, Falls and Syncope Orthostatic hypotension, falls, and syncope have been reported in patients treated with the recommended CYMBALTA dosages.",
   "photosensitivity": true,
   "photosensitivity_direct": true,
   "photosensitivity_context": "side effect",
   "photosensitivity_section": "Adverse reactions",
   "photosensitivity_excerpt": "Skin and Subcutaneous Tissue Disorders — Frequent: pruritus; Infrequent: cold sweat, dermatitis contact, erythema, increased tendency to bruise, night sweats, and photosensitivity reaction; Rare: ecchymosis.",
   "heat_kind": null,
   "names_sauna_or_hot_tub": false,
   "storage": "Store at 25°C (77°F); excursions permitted to 15-30°C (59-86°F) [see USP Controlled Room Temperature]."
  },
  {
   "drug": "Wellbutrin XL",
   "generic": "bupropion",
   "class": "Antidepressant",
   "group": "Antidepressants and lithium",
   "label_title": "WELLBUTRIN XL / BUPROPION HYDROCHLORIDE",
   "label_type": "Rx",
   "set_id": "a435da9d-f6e8-4ddc-897d-8cd2bf777b21",
   "label_version": "27",
   "label_effective": "2026-02-10",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=a435da9d-f6e8-4ddc-897d-8cd2bf777b21",
   "guide": "https://www.tendground.com/journal/wellness-on-antidepressants-what-is-safe",
   "heat_or_thermoregulation": false,
   "decreased_sweating": false,
   "sweating": true,
   "sweating_direct": true,
   "sweating_context": "side effect",
   "sweating_section": "Adverse reactions",
   "sweating_excerpt": "…are (incidence ≥5%; ≥2× placebo rate): dry mouth, nausea, insomnia, dizziness, pharyngitis, abdominal pain, agitation, anxiety, tremor, palpitation, sweating, tinnitus, myalgia, anorexia, urinary frequency, rash. ( 6.1 ) To report SUSPECTED ADVERSE REACTIONS, contact Bausch Health US, LLC at…",
   "hyperthermia": false,
   "dehydration": false,
   "orthostatic_hypotension": true,
   "orthostatic_hypotension_direct": true,
   "orthostatic_hypotension_context": "side effect",
   "orthostatic_hypotension_section": "Adverse reactions",
   "orthostatic_hypotension_excerpt": "Cardiovascular Postural hypotension, hypertension, stroke, vasodilation, syncope, complete atrioventricular block, extrasystoles, myocardial infarction, phlebitis, pulmonary embolism, and Brugada pattern/syndrome.",
   "photosensitivity": true,
   "photosensitivity_direct": true,
   "photosensitivity_context": "side effect",
   "photosensitivity_section": "Adverse reactions",
   "photosensitivity_excerpt": "Body (General) Chills, facial edema, edema, peripheral edema, musculoskeletal chest pain, photosensitivity, and malaise.",
   "heat_kind": null,
   "names_sauna_or_hot_tub": false,
   "storage": "Store at 25°C (77°F); excursions permitted to 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature]."
  },
  {
   "drug": "amitriptyline",
   "generic": "amitriptyline",
   "class": "Antidepressant (tricyclic)",
   "group": "Antidepressants and lithium",
   "label_title": "Amitriptyline Hydrochloride / AMITRIPTYLINE HYDROCHLORIDE",
   "label_type": "Rx",
   "set_id": "4e520c63-1cf6-40f6-a51c-3f9b0e181342",
   "label_version": "10",
   "label_effective": "2026-09-08",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=4e520c63-1cf6-40f6-a51c-3f9b0e181342",
   "guide": "https://www.tendground.com/journal/heat-cold-and-common-medications",
   "heat_or_thermoregulation": true,
   "heat_or_thermoregulation_direct": false,
   "heat_or_thermoregulation_context": "drug interaction",
   "heat_or_thermoregulation_section": "Precautions",
   "heat_or_thermoregulation_excerpt": "Hyperpyrexia has been reported when amitriptyline is administered with anticholinergic agents or with neuroleptic drugs, particularly during hot weather.",
   "decreased_sweating": false,
   "sweating": true,
   "sweating_direct": true,
   "sweating_context": "side effect",
   "sweating_section": "Adverse reactions",
   "sweating_excerpt": "Other: Alopecia; edema; weight gain or loss; urinary frequency; increased perspiration; hyponatremia.",
   "hyperthermia": true,
   "hyperthermia_direct": true,
   "hyperthermia_context": "side effect",
   "hyperthermia_section": "Adverse reactions",
   "hyperthermia_excerpt": "Anticholinergic: Paralytic ileus; hyperpyrexia; urinary retention; dilatation of the urinary tract; constipation; blurred vision, disturbance of accommodation, increased ocular pressure, mydriasis; dry mouth.",
   "dehydration": false,
   "orthostatic_hypotension": true,
   "orthostatic_hypotension_direct": true,
   "orthostatic_hypotension_context": "side effect",
   "orthostatic_hypotension_section": "Adverse reactions",
   "orthostatic_hypotension_excerpt": "Cardiovascular: Myocardial infarction; stroke; nonspecific ECG changes and changes in AV conduction; heart block; arrhythmias; hypotension, particularly orthostatic hypotension; syncope; hypertension; tachycardia; palpitation.",
   "photosensitivity": true,
   "photosensitivity_direct": true,
   "photosensitivity_context": "side effect",
   "photosensitivity_section": "Adverse reactions",
   "photosensitivity_excerpt": "Allergic: Skin rash; urticaria; photosensitization; edema of face and tongue.",
   "heat_kind": "hot_weather",
   "names_sauna_or_hot_tub": false,
   "storage": "Store at 20° to 25°C (68° to 77°F)."
  },
  {
   "drug": "lithium carbonate",
   "generic": "lithium",
   "class": "Mood stabilizer",
   "group": "Antidepressants and lithium",
   "label_title": "Lithium Carbonate / LITHIUM CARBONATE",
   "label_type": "Rx",
   "set_id": "d3284649-ed4c-4096-987b-4ac16b8278f2",
   "label_version": "9",
   "label_effective": "2023-10-02",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=d3284649-ed4c-4096-987b-4ac16b8278f2",
   "guide": "https://www.tendground.com/journal/wellness-with-bipolar-disorder-what-is-safe",
   "heat_or_thermoregulation": true,
   "heat_or_thermoregulation_direct": true,
   "heat_or_thermoregulation_context": "patient advice",
   "heat_or_thermoregulation_section": "Medication Guide",
   "heat_or_thermoregulation_excerpt": "Avoid becoming overheated or dehydrated during exercise and in hot weather.",
   "decreased_sweating": false,
   "sweating": true,
   "sweating_direct": true,
   "sweating_context": "warning",
   "sweating_section": "Warnings and precautions",
   "sweating_excerpt": "Dehydration from protracted sweating, diarrhea, or elevated temperatures from infection increases risk of hyponatremia and lithium toxicity.",
   "hyperthermia": true,
   "hyperthermia_direct": false,
   "hyperthermia_context": "serotonin syndrome symptom",
   "hyperthermia_section": "Warnings and precautions",
   "hyperthermia_excerpt": "…agitation, hallucinations, delirium, and coma), autonomic instability (e.g., tachycardia, labile blood pressure, dizziness, diaphoresis, flushing, hyperthermia), neuromuscular symptoms (e.g., tremor, rigidity, myoclonus, hyperreflexia, incoordination), seizures, and gastrointestinal symptoms (e.g., nausea,…",
   "dehydration": true,
   "dehydration_direct": true,
   "dehydration_context": "warning",
   "dehydration_section": "Warnings and precautions",
   "dehydration_excerpt": "Dehydration from protracted sweating, diarrhea, or elevated temperatures from infection increases risk of hyponatremia and lithium toxicity.",
   "orthostatic_hypotension": false,
   "photosensitivity": false,
   "heat_kind": "hot_weather",
   "names_sauna_or_hot_tub": false,
   "storage": "Store and Dispense Store at 20° to 25°C (68° to 77°F); excursions permitted between 15° and 30°C (59° and 86°F) [see USP Controlled Room Temperature]."
  },
  {
   "drug": "Abilify",
   "generic": "aripiprazole",
   "class": "Antipsychotic",
   "group": "Antipsychotics",
   "label_title": "ABILIFY / ARIPIPRAZOLE",
   "label_type": "Rx",
   "set_id": "c040bd1d-45b7-49f2-93ea-aed7220b30ac",
   "label_version": "73",
   "label_effective": "2025-01-29",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=c040bd1d-45b7-49f2-93ea-aed7220b30ac",
   "guide": "https://www.tendground.com/journal/wellness-on-abilify-risperdal-or-zyprexa-what-is-safe",
   "heat_or_thermoregulation": true,
   "heat_or_thermoregulation_direct": true,
   "heat_or_thermoregulation_context": "warning",
   "heat_or_thermoregulation_section": "Warnings and precautions",
   "heat_or_thermoregulation_excerpt": "5.13 Body Temperature Regulation Disruption of the body's ability to reduce core body temperature has been attributed to antipsychotic agents.",
   "decreased_sweating": false,
   "sweating": true,
   "sweating_direct": true,
   "sweating_context": "side effect",
   "sweating_section": "Adverse reactions",
   "sweating_excerpt": "…Respiratory, Thoracic, and Mediastinal Disorders: infrequent – nasal congestion, dyspnea Skin and Subcutaneous Tissue Disorders: infrequent – rash, hyperhidrosis, pruritus, photosensitivity reaction, alopecia; rare – urticaria Vascular Disorders: infrequent – hypotension, hypertension Pediatric Patients Most…",
   "hyperthermia": true,
   "hyperthermia_direct": true,
   "hyperthermia_context": "side effect",
   "hyperthermia_section": "Adverse reactions",
   "hyperthermia_excerpt": "…– hepatitis, jaundice Immune System Disorders: rare – hypersensitivity Injury, Poisoning, and Procedural Complications: infrequent – fall; rare – heat stroke Investigations: frequent – blood prolactin decreased, weight decreased, infrequent – hepatic enzyme increased, blood glucose increased, blood…",
   "dehydration": true,
   "dehydration_direct": true,
   "dehydration_context": "warning",
   "dehydration_section": "Warnings and precautions",
   "dehydration_excerpt": "…) Orthostatic Hypotension: Monitor heart rate and blood pressure and warn patients with known cardiovascular or cerebrovascular disease, and risk of dehydration or syncope ( 5.8 ) Leukopenia, Neutropenia, and Agranulocytosis: have been reported with antipsychotics including ABILIFY. Patients with a history…",
   "orthostatic_hypotension": true,
   "orthostatic_hypotension_direct": true,
   "orthostatic_hypotension_context": "warning",
   "orthostatic_hypotension_section": "Warnings and precautions",
   "orthostatic_hypotension_excerpt": "…antipsychotic use. Monitor weight ( 5.6 ) Pathological Gambling and Other Compulsive Behaviors: Consider dose reduction or discontinuation ( 5.7 ) Orthostatic Hypotension: Monitor heart rate and blood pressure and warn patients with known cardiovascular or cerebrovascular disease, and risk of dehydration or syncope (…",
   "photosensitivity": true,
   "photosensitivity_direct": true,
   "photosensitivity_context": "side effect",
   "photosensitivity_section": "Adverse reactions",
   "photosensitivity_excerpt": "…Mediastinal Disorders: infrequent – nasal congestion, dyspnea Skin and Subcutaneous Tissue Disorders: infrequent – rash, hyperhidrosis, pruritus, photosensitivity reaction, alopecia; rare – urticaria Vascular Disorders: infrequent – hypotension, hypertension Pediatric Patients Most adverse events observed in…",
   "heat_kind": "thermoregulation",
   "names_sauna_or_hot_tub": false,
   "storage": "Store at 25°C (77°F); excursions permitted between 15°C to 30°C (59°F to 86°F)[see USP Controlled Room Temperature]."
  },
  {
   "drug": "Risperdal",
   "generic": "risperidone",
   "class": "Antipsychotic",
   "group": "Antipsychotics",
   "label_title": "RISPERDAL / RISPERIDONE",
   "label_type": "Rx",
   "set_id": "7e117c7e-02fc-4343-92a1-230061dfc5e0",
   "label_version": "45",
   "label_effective": "2026-05-28",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=7e117c7e-02fc-4343-92a1-230061dfc5e0",
   "guide": "https://www.tendground.com/journal/wellness-on-abilify-risperdal-or-zyprexa-what-is-safe",
   "heat_or_thermoregulation": true,
   "heat_or_thermoregulation_direct": true,
   "heat_or_thermoregulation_context": "warning",
   "heat_or_thermoregulation_section": "Warnings and precautions",
   "heat_or_thermoregulation_excerpt": "5.14 Body Temperature Regulation Disruption of body temperature regulation has been attributed to antipsychotic agents.",
   "decreased_sweating": false,
   "sweating": true,
   "sweating_direct": false,
   "sweating_context": "neuroleptic malignant syndrome symptom",
   "sweating_section": "Warnings and precautions",
   "sweating_excerpt": "Clinical manifestations of NMS are hyperpyrexia, muscle rigidity, altered mental status including delirium, and autonomic instability (irregular pulse or blood pressure, tachycardia, diaphoresis, and cardiac dysrhythmia).",
   "hyperthermia": true,
   "hyperthermia_direct": true,
   "hyperthermia_context": "heat exposure or thermoregulation",
   "hyperthermia_section": "Warnings and precautions",
   "hyperthermia_excerpt": "Both hyperthermia and hypothermia have been reported in association with oral RISPERDAL use.",
   "dehydration": true,
   "dehydration_direct": true,
   "dehydration_context": "warning",
   "dehydration_section": "Warnings and precautions",
   "dehydration_excerpt": "…disease (history of myocardial infarction or ischemia, heart failure, or conduction abnormalities), cerebrovascular disease, and conditions which would predispose patients to hypotension, e.g., dehydration and hypovolemia, and in the elderly and patients with renal or hepatic impairment.",
   "orthostatic_hypotension": true,
   "orthostatic_hypotension_direct": true,
   "orthostatic_hypotension_context": "warning",
   "orthostatic_hypotension_section": "Warnings and precautions",
   "orthostatic_hypotension_excerpt": "( 5.6 ) Orthostatic hypotension: For patients at risk, consider a lower starting dose and slower titration.",
   "photosensitivity": false,
   "heat_kind": "thermoregulation",
   "names_sauna_or_hot_tub": false,
   "storage": "stored at controlled room temperature 15 °C to 25 °C (59 °F to 77 °F)."
  },
  {
   "drug": "Zyprexa",
   "generic": "olanzapine",
   "class": "Antipsychotic",
   "group": "Antipsychotics",
   "label_title": "Zyprexa / olanzapine",
   "label_type": "Rx",
   "set_id": "3609727e-21e1-4e39-b158-ec3518a3ff09",
   "label_version": "1",
   "label_effective": "2026-03-06",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=3609727e-21e1-4e39-b158-ec3518a3ff09",
   "guide": "https://www.tendground.com/journal/wellness-on-abilify-risperdal-or-zyprexa-what-is-safe",
   "heat_or_thermoregulation": true,
   "heat_or_thermoregulation_direct": true,
   "heat_or_thermoregulation_context": "warning",
   "heat_or_thermoregulation_section": "Warnings and precautions",
   "heat_or_thermoregulation_excerpt": "5.13 Body Temperature Regulation Disruption of the body's ability to reduce core body temperature has been attributed to antipsychotic agents.",
   "decreased_sweating": false,
   "sweating": true,
   "sweating_direct": true,
   "sweating_context": "side effect",
   "sweating_section": "Adverse reactions",
   "sweating_excerpt": "…5 2 Paresthesia 5 2 Apathy 4 3 Confusion 4 1 Euphoria 3 2 Incoordination 2 0 Respiratory System Pharyngitis 4 1 Dyspnea 3 1 Skin and Appendages Sweating 3 1 Acne 2 0 Dry skin 2 0 Special Senses Amblyopia 9 5 Abnormal vision 2 0 Urogenital System Dysmenorrhea a 2 0 Vaginitis a 2 0 For specific…",
   "hyperthermia": true,
   "hyperthermia_direct": false,
   "hyperthermia_context": "neuroleptic malignant syndrome symptom",
   "hyperthermia_section": "Warnings and precautions",
   "hyperthermia_excerpt": "Clinical manifestations of NMS are hyperpyrexia, muscle rigidity, altered mental status and evidence of autonomic instability (irregular pulse or blood pressure, tachycardia, diaphoresis and cardiac dysrhythmia).",
   "dehydration": true,
   "dehydration_direct": true,
   "dehydration_context": "warning",
   "dehydration_section": "Warnings and precautions",
   "dehydration_excerpt": "…or ischemia, heart failure, or conduction abnormalities), cerebrovascular disease, and conditions which would predispose patients to hypotension (dehydration, hypovolemia, and treatment with antihypertensive medications) where the occurrence of syncope, or hypotension and/or bradycardia might put the…",
   "orthostatic_hypotension": true,
   "orthostatic_hypotension_direct": true,
   "orthostatic_hypotension_context": "warning",
   "orthostatic_hypotension_section": "Warnings and precautions",
   "orthostatic_hypotension_excerpt": "( 5.6 ) Orthostatic Hypotension: Orthostatic hypotension associated with dizziness, tachycardia, bradycardia and, in some patients, syncope, may occur especially during initial dose titration.",
   "photosensitivity": true,
   "photosensitivity_direct": true,
   "photosensitivity_context": "side effect",
   "photosensitivity_section": "Adverse reactions",
   "photosensitivity_excerpt": "Body as a Whole — Infrequent: chills, face edema, photosensitivity reaction, suicide attempt 1 ; Rare: chills and fever, hangover effect, sudden death 1 .",
   "heat_kind": "thermoregulation",
   "names_sauna_or_hot_tub": false,
   "storage": "Store ZYPREXA tablets, ZYPREXA ZYDIS, and ZYPREXA IntraMuscular vials (before reconstitution) at controlled room temperature, 20° to 25°C (68° to 77°F) [ see USP]."
  },
  {
   "drug": "Seroquel",
   "generic": "quetiapine",
   "class": "Antipsychotic",
   "group": "Antipsychotics",
   "label_title": "SEROQUEL / QUETIAPINE",
   "label_type": "Rx",
   "set_id": "8ae62aaf-f8c5-417f-baac-0098369ca322",
   "label_version": "53",
   "label_effective": "2026-04-10",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=8ae62aaf-f8c5-417f-baac-0098369ca322",
   "guide": "https://www.tendground.com/journal/wellness-on-quetiapine-seroquel-what-is-safe",
   "heat_or_thermoregulation": true,
   "heat_or_thermoregulation_direct": true,
   "heat_or_thermoregulation_context": "warning",
   "heat_or_thermoregulation_section": "Warnings and precautions",
   "heat_or_thermoregulation_excerpt": "5.17 Body Temperature Regulation Although not reported with SEROQUEL, disruption of the body's ability to reduce core body temperature has been attributed to antipsychotic agents.",
   "decreased_sweating": false,
   "sweating": true,
   "sweating_direct": true,
   "sweating_context": "side effect",
   "sweating_section": "Adverse reactions",
   "sweating_excerpt": "…2% 1% Increased Appetite 2% 1% Hypothyroidism 2% 1% Incoordination 2% 1% Thinking Abnormal 2% 0% Anxiety 2% 0% Ataxia 2% 0% Sinusitis 2% 1% Sweating 2% 1% Urinary Tract Infection 2% 1% In bipolar depression studies (up to 8 weeks), the most commonly observed adverse reactions associated with the…",
   "hyperthermia": true,
   "hyperthermia_direct": true,
   "hyperthermia_context": "side effect",
   "hyperthermia_section": "Medication Guide",
   "hyperthermia_excerpt": "SEROQUEL can cause serious side effects, including: … • increased body temperature",
   "dehydration": true,
   "dehydration_direct": true,
   "dehydration_context": "warning",
   "dehydration_section": "Warnings and precautions",
   "dehydration_excerpt": "…(history of myocardial infarction or ischemic heart disease, heart failure, or conduction abnormalities), cerebrovascular disease or conditions which would predispose patients to hypotension (dehydration, hypovolemia, and treatment with antihypertensive medications).",
   "orthostatic_hypotension": true,
   "orthostatic_hypotension_direct": true,
   "orthostatic_hypotension_context": "warning",
   "orthostatic_hypotension_section": "Warnings and precautions",
   "orthostatic_hypotension_excerpt": "5.7 Hypotension Quetiapine may induce orthostatic hypotension associated with dizziness, tachycardia and, in some patients, syncope, especially during the initial dose-titration period, probably reflecting its α 1 -adrenergic antagonist properties.",
   "photosensitivity": false,
   "heat_kind": "thermoregulation",
   "names_sauna_or_hot_tub": false,
   "storage": "Store at 25ºC (77ºF); excursions permitted to 15-30ºC (59-86ºF) [See USP]."
  },
  {
   "drug": "Seroquel XR",
   "generic": "quetiapine, extended release",
   "class": "Antipsychotic",
   "group": "Antipsychotics",
   "label_title": "SEROQUEL XR / QUETIAPINE",
   "label_type": "Rx",
   "set_id": "ab959a35-d0ba-4f18-8f2e-6619d88b16e3",
   "label_version": "50",
   "label_effective": "2026-04-10",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=ab959a35-d0ba-4f18-8f2e-6619d88b16e3",
   "guide": "https://www.tendground.com/journal/wellness-on-quetiapine-seroquel-what-is-safe",
   "heat_or_thermoregulation": true,
   "heat_or_thermoregulation_direct": true,
   "heat_or_thermoregulation_context": "warning",
   "heat_or_thermoregulation_section": "Warnings and precautions",
   "heat_or_thermoregulation_excerpt": "5.17 Body Temperature Regulation Disruption of the body's ability to reduce core body temperature has been attributed to antipsychotic agents.",
   "decreased_sweating": false,
   "sweating": true,
   "sweating_direct": true,
   "sweating_context": "side effect",
   "sweating_section": "Adverse reactions",
   "sweating_excerpt": "…2% 1% Migraine 2% 1% Restless Legs Syndrome 2% 1% Anxiety 2% 1% Sinus Headache 2% 1% Libido Decreased 2% 1% Pollakiuria 2% 1% Sinus Congestion 2% 1% Hyperhidrosis 2% 1% Orthostatic Hypotension 2% 1% Urinary Tract Infection 2% 0% Heart Rate Increased 2% 0% Neck Pain 2% 0% Dysarthria 2% 0% Akathisia 2% 0%…",
   "hyperthermia": true,
   "hyperthermia_direct": true,
   "hyperthermia_context": "side effect",
   "hyperthermia_section": "Medication Guide",
   "hyperthermia_excerpt": "SEROQUEL XR can cause serious side effects, including: … • increased body temperature",
   "dehydration": true,
   "dehydration_direct": true,
   "dehydration_context": "warning",
   "dehydration_section": "Warnings and precautions",
   "dehydration_excerpt": "…(history of myocardial infarction or ischemic heart disease, heart failure, or conduction abnormalities), cerebrovascular disease, or conditions which would predispose patients to hypotension (dehydration, hypovolemia, and treatment with antihypertensive medications).",
   "orthostatic_hypotension": true,
   "orthostatic_hypotension_direct": true,
   "orthostatic_hypotension_context": "warning",
   "orthostatic_hypotension_section": "Warnings and precautions",
   "orthostatic_hypotension_excerpt": "5.7 Hypotension Quetiapine may induce orthostatic hypotension associated with dizziness, tachycardia and, in some patients, syncope, especially during the initial dose-titration period, probably reflecting its ά1-adrenergic antagonist properties.",
   "photosensitivity": false,
   "heat_kind": "thermoregulation",
   "names_sauna_or_hot_tub": false,
   "storage": "Store SEROQUEL XR at 25ºC (77ºF); excursions permitted to 15-30ºC (59-86ºF) [See USP]."
  },
  {
   "drug": "haloperidol",
   "generic": "haloperidol",
   "class": "Antipsychotic (first generation)",
   "group": "Antipsychotics",
   "label_title": "Haloperidol / HALOPERIDOL",
   "label_type": "Rx",
   "set_id": "afb3ac3e-7459-42d3-b5ca-e0d6d27ced73",
   "label_version": "7",
   "label_effective": "2026-08-05",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=afb3ac3e-7459-42d3-b5ca-e0d6d27ced73",
   "guide": null,
   "heat_or_thermoregulation": false,
   "decreased_sweating": false,
   "sweating": true,
   "sweating_direct": true,
   "sweating_context": "side effect",
   "sweating_section": "Adverse reactions",
   "sweating_excerpt": "Autonomic Reactions Dry mouth, blurred vision, urinary retention, diaphoresis and priapism.",
   "hyperthermia": true,
   "hyperthermia_direct": true,
   "hyperthermia_context": "warning",
   "hyperthermia_section": "Warnings",
   "hyperthermia_excerpt": "Hyperpyrexia and heat stroke, not associated with the above symptom complex, have also been reported with haloperidol.",
   "dehydration": true,
   "dehydration_direct": true,
   "dehydration_context": "warning",
   "dehydration_section": "Warnings",
   "dehydration_excerpt": "It has been postulated that lethargy and decreased sensation of thirst due to central inhibition may lead to dehydration, hemoconcentration and reduced pulmonary ventilation.",
   "orthostatic_hypotension": true,
   "orthostatic_hypotension_direct": true,
   "orthostatic_hypotension_context": "warning",
   "orthostatic_hypotension_section": "Warnings",
   "orthostatic_hypotension_excerpt": "Falls Haloperidol tablets may cause somnolence, postural hypotension, motor and sensory instability, which may lead to falls and, consequently, fractures or other injuries.",
   "photosensitivity": true,
   "photosensitivity_direct": true,
   "photosensitivity_context": "side effect",
   "photosensitivity_section": "Adverse reactions",
   "photosensitivity_excerpt": "Dermatologic Reactions Maculopapular and acneiform skin reactions and isolated cases of photosensitivity and loss of hair.",
   "heat_kind": null,
   "names_sauna_or_hot_tub": false,
   "storage": "Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]."
  },
  {
   "drug": "Clozaril",
   "generic": "clozapine",
   "class": "Antipsychotic",
   "group": "Antipsychotics",
   "label_title": "Clozaril / CLOZAPINE",
   "label_type": "Rx",
   "set_id": "90876802-0e3a-44c9-9ff7-1754dfbe736a",
   "label_version": "21",
   "label_effective": "2025-06-06",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=90876802-0e3a-44c9-9ff7-1754dfbe736a",
   "guide": null,
   "heat_or_thermoregulation": false,
   "decreased_sweating": false,
   "sweating": true,
   "sweating_direct": true,
   "sweating_context": "side effect",
   "sweating_section": "Adverse reactions",
   "sweating_excerpt": "…including sedation, dizziness/vertigo, headache, and tremor; cardiovascular reactions, including tachycardia, hypotension, and syncope; autonomic nervous system reactions, including hypersalivation, sweating, dry mouth, and visual disturbances; gastrointestinal reactions, including constipation and nausea; and fever.",
   "hyperthermia": true,
   "hyperthermia_direct": true,
   "hyperthermia_context": "side effect",
   "hyperthermia_section": "Adverse reactions",
   "hyperthermia_excerpt": "…CLOZARIL (N=126) (%) Chlorpromazine (N=142) (%) Sedation 21 13 Tachycardia 17 11 Constipation 16 12 Dizziness 14 16 Hypotension 13 38 Fever (hyperthermia) 13 4 Hypersalivation 13 1 Hypertension 12 5 Headache 10 10 Nausea/vomiting 10 12 Dry mouth 5 20 Table 10 summarizes the adverse reactions reported…",
   "dehydration": true,
   "dehydration_direct": true,
   "dehydration_context": "warning",
   "dehydration_section": "Boxed warning",
   "dehydration_excerpt": "Use CLOZARIL cautiously in patients with cardiovascular or cerebrovascular disease or conditions predisposing to hypotension (e.g., dehydration, use of antihypertensive medications) [see Dosage and Administration ( 2.2 , 2.6 ), Warnings and Precautions ( 5.2 )].",
   "orthostatic_hypotension": true,
   "orthostatic_hypotension_direct": true,
   "orthostatic_hypotension_context": "warning",
   "orthostatic_hypotension_section": "Boxed warning",
   "orthostatic_hypotension_excerpt": "WARNING: SEVERE NEUTROPENIA; ORTHOSTATIC HYPOTENSION, BRADYCARDIA, AND SYNCOPE; SEIZURE; MYOCARDITIS, PERICARDITIS AND CARDIOMYOPATHY; INCREASED MORTALITY IN ELDERLY PATIENTS WITH DEMENTIA-RELATED PSYCHOSIS Severe Neutropenia CLOZARIL has caused…",
   "photosensitivity": true,
   "photosensitivity_direct": true,
   "photosensitivity_context": "side effect",
   "photosensitivity_section": "Adverse reactions",
   "photosensitivity_excerpt": "Skin and Subcutaneous Tissue Disorders Hypersensitivity reactions: photosensitivity, vasculitis, erythema multiforme, skin pigmentation disorder, and Stevens-Johnson Syndrome.",
   "heat_kind": null,
   "names_sauna_or_hot_tub": false,
   "storage": "Store CLOZARIL at room temperature between 20°C to 25°C (68°F to 77°F); excursion permitted between 15°C to 30°C (59°F to 86°F) [see USP Controlled Room Temperature]."
  },
  {
   "drug": "Topamax",
   "generic": "topiramate",
   "class": "Anticonvulsant",
   "group": "Anticonvulsants",
   "label_title": "Topamax / TOPIRAMATE",
   "label_type": "Rx",
   "set_id": "21628112-0c47-11df-95b3-498d55d89593",
   "label_version": "30",
   "label_effective": "2026-03-12",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=21628112-0c47-11df-95b3-498d55d89593",
   "guide": "https://www.tendground.com/journal/wellness-on-topiramate-topamax-what-is-safe",
   "heat_or_thermoregulation": true,
   "heat_or_thermoregulation_direct": true,
   "heat_or_thermoregulation_context": "warning",
   "heat_or_thermoregulation_section": "Warnings and precautions",
   "heat_or_thermoregulation_excerpt": "Patients (especially pediatric patients) treated with TOPAMAX should be monitored closely for evidence of decreased sweating and increased body temperature, especially in hot weather.",
   "decreased_sweating": true,
   "decreased_sweating_direct": true,
   "decreased_sweating_context": "warning",
   "decreased_sweating_section": "Warnings and precautions",
   "decreased_sweating_excerpt": "5.3 Oligohidrosis and Hyperthermia Oligohidrosis (decreased sweating), infrequently resulting in hospitalization, has been reported in association with TOPAMAX use. Decreased sweating and an elevation in body temperature above normal characterized these cases.",
   "sweating": false,
   "hyperthermia": true,
   "hyperthermia_direct": true,
   "hyperthermia_context": "heat exposure or thermoregulation",
   "hyperthermia_section": "Warnings and precautions",
   "hyperthermia_excerpt": "5.3 Oligohidrosis and Hyperthermia Oligohidrosis (decreased sweating), infrequently resulting in hospitalization, has been reported in association with TOPAMAX use. Decreased sweating and an elevation in body temperature above normal characterized these cases.",
   "dehydration": false,
   "orthostatic_hypotension": true,
   "orthostatic_hypotension_direct": true,
   "orthostatic_hypotension_context": "side effect",
   "orthostatic_hypotension_section": "Adverse reactions",
   "orthostatic_hypotension_excerpt": "Other Adverse Reactions Observed During Clinical Trials Other adverse reactions seen during clinical trials were: abnormal coordination, eosinophilia, gingival bleeding, hematuria, hypotension, myalgia, myopia, postural hypotension, scotoma, suicide attempt, syncope, and visual field defect.",
   "photosensitivity": false,
   "heat_kind": "less_sweating",
   "names_sauna_or_hot_tub": false,
   "storage": "stored in tightly-closed containers at controlled room temperature (59 ° to 86 °F, 15 ° to 30 °C)."
  },
  {
   "drug": "Qsymia",
   "generic": "phentermine and topiramate",
   "class": "Weight-loss (topiramate combination)",
   "group": "Anticonvulsants",
   "label_title": "Qsymia / PHENTERMINE AND TOPIRAMATE",
   "label_type": "Rx",
   "set_id": "40dd5602-53da-45ac-bb4b-15789aba40f9",
   "label_version": "42",
   "label_effective": "2026-04-22",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=40dd5602-53da-45ac-bb4b-15789aba40f9",
   "guide": "https://www.tendground.com/journal/wellness-on-topiramate-topamax-what-is-safe",
   "heat_or_thermoregulation": true,
   "heat_or_thermoregulation_direct": true,
   "heat_or_thermoregulation_context": "warning",
   "heat_or_thermoregulation_section": "Warnings and precautions",
   "heat_or_thermoregulation_excerpt": "Advise all patients and caregivers to monitor for decreased sweating and increased body temperature during physical activity, especially in hot weather.",
   "decreased_sweating": true,
   "decreased_sweating_direct": true,
   "decreased_sweating_context": "warning",
   "decreased_sweating_section": "Warnings and precautions",
   "decreased_sweating_excerpt": "5.11 Oligohidrosis and Hyperthermia Oligohidrosis (decreased sweating), infrequently resulting in hospitalization, has been reported in association with the use of topiramate.",
   "sweating": false,
   "hyperthermia": true,
   "hyperthermia_direct": true,
   "hyperthermia_context": "heat exposure or thermoregulation",
   "hyperthermia_section": "Warnings and precautions",
   "hyperthermia_excerpt": "5.11 Oligohidrosis and Hyperthermia Oligohidrosis (decreased sweating), infrequently resulting in hospitalization, has been reported in association with the use of topiramate.",
   "dehydration": false,
   "orthostatic_hypotension": false,
   "photosensitivity": false,
   "heat_kind": "less_sweating",
   "names_sauna_or_hot_tub": false,
   "storage": "Store at 20°C to 25°C (68°F to 77°F), excursions permitted between 15°C and 30°C (59°F and 86°F) [see USP Controlled Room Temperature]."
  },
  {
   "drug": "Zonisade",
   "generic": "zonisamide",
   "class": "Anticonvulsant",
   "group": "Anticonvulsants",
   "label_title": "ZONISADE / ZONISAMIDE",
   "label_type": "Rx",
   "set_id": "ac16fa15-32e9-4f92-8bc6-d8d41ae002c6",
   "label_version": "3",
   "label_effective": "2025-09-08",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=ac16fa15-32e9-4f92-8bc6-d8d41ae002c6",
   "guide": "https://www.tendground.com/journal/wellness-on-topiramate-topamax-what-is-safe",
   "heat_or_thermoregulation": true,
   "heat_or_thermoregulation_direct": true,
   "heat_or_thermoregulation_context": "warning",
   "heat_or_thermoregulation_section": "Warnings and precautions",
   "heat_or_thermoregulation_excerpt": "Patients, especially pediatric patients, treated with ZONISADE should be monitored closely for evidence of decreased sweating and increased body temperature, especially in warm or hot weather.",
   "decreased_sweating": true,
   "decreased_sweating_direct": true,
   "decreased_sweating_context": "warning",
   "decreased_sweating_section": "Warnings and precautions",
   "decreased_sweating_excerpt": "Oligohidrosis and Hyperthermia in Pediatric Patients: Oligohidrosis, sometimes resulting in heat stroke and hospitalization, is seen in association with zonisamide in pediatric patients ( 5.5 ).",
   "sweating": true,
   "sweating_direct": true,
   "sweating_context": "side effect",
   "sweating_section": "Adverse reactions",
   "sweating_excerpt": "Infrequent: Maculopapular rash, acne, alopecia, dry skin, sweating, eczema, urticaria, hirsutism, pustular rash, vesiculobullous rash.",
   "hyperthermia": true,
   "hyperthermia_direct": true,
   "hyperthermia_context": "heat exposure or thermoregulation",
   "hyperthermia_section": "Warnings and precautions",
   "hyperthermia_excerpt": "Oligohidrosis and Hyperthermia in Pediatric Patients: Oligohidrosis, sometimes resulting in heat stroke and hospitalization, is seen in association with zonisamide in pediatric patients ( 5.5 ).",
   "dehydration": true,
   "dehydration_direct": true,
   "dehydration_context": "side effect",
   "dehydration_section": "Adverse reactions",
   "dehydration_excerpt": "Metabolic and Nutritional : Infrequent: Peripheral edema, weight gain, edema, thirst, dehydration.",
   "orthostatic_hypotension": false,
   "photosensitivity": false,
   "heat_kind": "less_sweating",
   "names_sauna_or_hot_tub": false,
   "storage": "Store at 20°C to 25°C (68°F to 77°F), excursions permitted from 15°C to 30°C (59°F to 86°F) [see USP Controlled Room Temperature]."
  },
  {
   "drug": "Lamictal",
   "generic": "lamotrigine",
   "class": "Anticonvulsant / mood stabilizer",
   "group": "Anticonvulsants",
   "label_title": "LAMICTAL / LAMOTRIGINE",
   "label_type": "Rx",
   "set_id": "d7e3572d-56fe-4727-2bb4-013ccca22678",
   "label_version": "45",
   "label_effective": "2025-10-10",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=d7e3572d-56fe-4727-2bb4-013ccca22678",
   "guide": "https://www.tendground.com/journal/wellness-on-lamotrigine-lamictal-what-is-safe",
   "heat_or_thermoregulation": false,
   "decreased_sweating": false,
   "sweating": true,
   "sweating_direct": true,
   "sweating_context": "side effect",
   "sweating_section": "Adverse reactions",
   "sweating_excerpt": "Skin and Appendages: Contact dermatitis, dry skin, sweating.",
   "hyperthermia": false,
   "dehydration": false,
   "orthostatic_hypotension": true,
   "orthostatic_hypotension_direct": true,
   "orthostatic_hypotension_context": "side effect",
   "orthostatic_hypotension_section": "Adverse reactions",
   "orthostatic_hypotension_excerpt": "Cardiovascular System Infrequent: Flushing, hot flashes, hypertension, palpitations, postural hypotension, syncope, tachycardia, vasodilation.",
   "photosensitivity": true,
   "photosensitivity_direct": true,
   "photosensitivity_context": "side effect",
   "photosensitivity_section": "Adverse reactions",
   "photosensitivity_excerpt": "…171) Body as a whole Infection 20 17 Fever 15 14 Accidental injury 14 12 Abdominal pain 10 5 Asthenia 8 4 Flu syndrome 7 6 Pain 5 4 Facial edema 2 1 Photosensitivity 2 0 Cardiovascular Hemorrhage 2 1 Digestive Vomiting 20 16 Diarrhea 11 9 Nausea 10 2 Constipation 4 2 Dyspepsia 2 1 Hemic and lymphatic…",
   "heat_kind": null,
   "names_sauna_or_hot_tub": false,
   "storage": "Store at 25°C (77°F); excursions permitted to 15°C to 30°C (59°F to 86°F) [see USP Controlled Room Temperature] in a dry place."
  },
  {
   "drug": "Neurontin",
   "generic": "gabapentin",
   "class": "Anticonvulsant / nerve pain",
   "group": "Anticonvulsants",
   "label_title": "Neurontin / GABAPENTIN",
   "label_type": "Rx",
   "set_id": "97935fd9-1d4a-43b6-a5d9-de994591187b",
   "label_version": "48",
   "label_effective": "2026-05-12",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=97935fd9-1d4a-43b6-a5d9-de994591187b",
   "guide": "https://www.tendground.com/journal/wellness-on-sedating-medication-what-is-safe",
   "heat_or_thermoregulation": false,
   "decreased_sweating": false,
   "sweating": true,
   "sweating_direct": false,
   "sweating_context": "withdrawal",
   "sweating_section": "Adverse reactions",
   "sweating_excerpt": "There are postmarketing reports of withdrawal symptoms after discontinuation of gabapentin. Reported adverse reactions include, but are not limited to, seizures, depression, suicidal ideation and behavior, agitation, confusion, disorientation, psychotic symptoms, anxiety, insomnia, nausea, pain, sweating, tremor, headache, dizziness, and malaise [see Warnings and Precautions (5.6) ] .",
   "hyperthermia": false,
   "dehydration": false,
   "orthostatic_hypotension": false,
   "photosensitivity": false,
   "heat_kind": null,
   "names_sauna_or_hot_tub": false,
   "storage": "Store NEURONTIN Tablets and Capsules at 25°C (77°F); excursions permitted between 15°C to 30°C (59°F to 86°F) [see USP Controlled Room Temperature]."
  },
  {
   "drug": "trazodone",
   "generic": "trazodone",
   "class": "Antidepressant / sleep",
   "group": "Sleep and anxiety",
   "label_title": "Trazodone Hydrochloride / TRAZODONE HYDROCHLORIDE",
   "label_type": "Rx",
   "set_id": "a57da4f8-151d-4a74-8710-6158d1da3852",
   "label_version": "4",
   "label_effective": "2026-09-03",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=a57da4f8-151d-4a74-8710-6158d1da3852",
   "guide": "https://www.tendground.com/journal/wellness-on-sedating-medication-what-is-safe",
   "heat_or_thermoregulation": false,
   "decreased_sweating": false,
   "sweating": true,
   "sweating_direct": false,
   "sweating_context": "serotonin syndrome symptom",
   "sweating_section": "Warnings and precautions",
   "sweating_excerpt": "…status changes (e.g., agitation, hallucinations, delirium, and coma), autonomic instability (e.g., tachycardia, labile blood pressure, dizziness, diaphoresis, flushing, hyperthermia), neuromuscular symptoms (e.g., tremor, rigidity, myoclonus, hyperreflexia, incoordination), seizures, and gastrointestinal…",
   "hyperthermia": true,
   "hyperthermia_direct": false,
   "hyperthermia_context": "serotonin syndrome symptom",
   "hyperthermia_section": "Warnings and precautions",
   "hyperthermia_excerpt": "…agitation, hallucinations, delirium, and coma), autonomic instability (e.g., tachycardia, labile blood pressure, dizziness, diaphoresis, flushing, hyperthermia), neuromuscular symptoms (e.g., tremor, rigidity, myoclonus, hyperreflexia, incoordination), seizures, and gastrointestinal symptoms (e.g., nausea,…",
   "dehydration": false,
   "orthostatic_hypotension": true,
   "orthostatic_hypotension_direct": true,
   "orthostatic_hypotension_context": "warning",
   "orthostatic_hypotension_section": "Warnings and precautions",
   "orthostatic_hypotension_excerpt": "Orthostatic Hypotension and Syncope: Warn patients of risk and symptoms of hypotension ( 5.4 ).",
   "photosensitivity": false,
   "heat_kind": null,
   "names_sauna_or_hot_tub": false,
   "storage": "Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]."
  },
  {
   "drug": "Xanax",
   "generic": "alprazolam",
   "class": "Benzodiazepine",
   "group": "Sleep and anxiety",
   "label_title": "Xanax / ALPRAZOLAM",
   "label_type": "Rx",
   "set_id": "bb5cf72e-3a41-41a8-9a38-80f974eca33f",
   "label_version": "4",
   "label_effective": "2024-04-15",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=bb5cf72e-3a41-41a8-9a38-80f974eca33f",
   "guide": "https://www.tendground.com/journal/wellness-on-sedating-medication-what-is-safe",
   "heat_or_thermoregulation": false,
   "decreased_sweating": false,
   "sweating": true,
   "sweating_direct": false,
   "sweating_context": "withdrawal",
   "sweating_section": "Adverse reactions",
   "sweating_excerpt": "…Decreased salivation 16.5% 13.6% 10.6% Metabolism and nutrition disorders Weight loss Decreased appetite 13.3% 12.8% Dermatological disorders Sweating 14.4% Cardiovascular disorders Tachycardia 12.2% Special Senses Blurred vision 10.0% There have also been reports of withdrawal seizures upon rapid…",
   "hyperthermia": false,
   "dehydration": false,
   "orthostatic_hypotension": false,
   "photosensitivity": true,
   "photosensitivity_direct": true,
   "photosensitivity_context": "side effect",
   "photosensitivity_section": "Adverse reactions",
   "photosensitivity_excerpt": "…failure Investigations: Liver enzyme elevations Psychiatric disorders: Hypomania, mania Reproductive system and breast disorders: Gynecomastia, galactorrhea Skin and subcutaneous tissue disorders: Photosensitivity reaction, angioedema, Stevens-Johnson syndrome",
   "heat_kind": null,
   "names_sauna_or_hot_tub": false,
   "storage": "Store at controlled room temperature 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]."
  },
  {
   "drug": "Ambien",
   "generic": "zolpidem",
   "class": "Sleep medication",
   "group": "Sleep and anxiety",
   "label_title": "Ambien / ZOLPIDEM TARTRATE",
   "label_type": "Rx",
   "set_id": "c36cadf4-65a4-4466-b409-c82020b42452",
   "label_version": "26",
   "label_effective": "2025-04-15",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=c36cadf4-65a4-4466-b409-c82020b42452",
   "guide": "https://www.tendground.com/journal/wellness-on-sedating-medication-what-is-safe",
   "heat_or_thermoregulation": false,
   "decreased_sweating": false,
   "sweating": true,
   "sweating_direct": true,
   "sweating_context": "side effect",
   "sweating_section": "Adverse reactions",
   "sweating_excerpt": "Autonomic nervous system: Infrequent: increased sweating, pallor, postural hypotension, syncope.",
   "hyperthermia": false,
   "dehydration": false,
   "orthostatic_hypotension": true,
   "orthostatic_hypotension_direct": true,
   "orthostatic_hypotension_context": "side effect",
   "orthostatic_hypotension_section": "Adverse reactions",
   "orthostatic_hypotension_excerpt": "Autonomic nervous system: Infrequent: increased sweating, pallor, postural hypotension, syncope.",
   "photosensitivity": true,
   "photosensitivity_direct": true,
   "photosensitivity_context": "side effect",
   "photosensitivity_section": "Adverse reactions",
   "photosensitivity_excerpt": "Rare: acne, bullous eruption, dermatitis, furunculosis, injection-site inflammation, photosensitivity reaction, urticaria.",
   "heat_kind": null,
   "names_sauna_or_hot_tub": false,
   "storage": "Store at controlled room temperature 20°C–25°C (68°F–77°F)."
  },
  {
   "drug": "oxybutynin",
   "generic": "oxybutynin",
   "class": "Anticholinergic (bladder)",
   "group": "Anticholinergics and antihistamines",
   "label_title": "Oxybutynin Chloride / OXYBUTYNIN CHLORIDE",
   "label_type": "Rx",
   "set_id": "7c497c6c-2448-2c80-e053-2991aa0ab8c7",
   "label_version": "6",
   "label_effective": "2026-07-27",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=7c497c6c-2448-2c80-e053-2991aa0ab8c7",
   "guide": "https://www.tendground.com/journal/heat-cold-and-common-medications",
   "heat_or_thermoregulation": true,
   "heat_or_thermoregulation_direct": true,
   "heat_or_thermoregulation_context": "warning",
   "heat_or_thermoregulation_section": "Precautions",
   "heat_or_thermoregulation_excerpt": "Patients should be informed that heat prostration (fever and heat stroke due to decreased sweating) can occur when anticholinergics such as oxybutynin chloride are administered in the presence of high environmental temperature.",
   "decreased_sweating": true,
   "decreased_sweating_direct": true,
   "decreased_sweating_context": "warning",
   "decreased_sweating_section": "Precautions",
   "decreased_sweating_excerpt": "Patients should be informed that heat prostration (fever and heat stroke due to decreased sweating) can occur when anticholinergics such as oxybutynin chloride are administered in the presence of high environmental temperature.",
   "sweating": false,
   "hyperthermia": true,
   "hyperthermia_direct": true,
   "hyperthermia_context": "heat exposure or thermoregulation",
   "hyperthermia_section": "Precautions",
   "hyperthermia_excerpt": "Patients should be informed that heat prostration (fever and heat stroke due to decreased sweating) can occur when anticholinergics such as oxybutynin chloride are administered in the presence of high environmental temperature.",
   "dehydration": true,
   "dehydration_direct": false,
   "dehydration_context": "overdose",
   "dehydration_section": "Overdosage",
   "dehydration_excerpt": "Overdosage with oxybutynin chloride has been associated with anticholinergic effects including central nervous system excitation (e.g., restlessness, tremor, irritability, convulsions, delirium, hallucinations), flushing, fever, dehydration, cardiac arrhythmia, vomiting, and urinary retention.",
   "orthostatic_hypotension": false,
   "photosensitivity": false,
   "heat_kind": "less_sweating",
   "names_sauna_or_hot_tub": false,
   "storage": "Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]."
  },
  {
   "drug": "benztropine",
   "generic": "benztropine",
   "class": "Anticholinergic (Parkinson's / drug-induced movement)",
   "group": "Anticholinergics and antihistamines",
   "label_title": "Benztropine Mesylate / BENZTROPINE MESYLATE",
   "label_type": "Rx",
   "set_id": "1ead16a7-88ed-407d-b25a-0d9a1d9da5ef",
   "label_version": "3",
   "label_effective": "2026-01-09",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=1ead16a7-88ed-407d-b25a-0d9a1d9da5ef",
   "guide": null,
   "heat_or_thermoregulation": true,
   "heat_or_thermoregulation_direct": true,
   "heat_or_thermoregulation_context": "warning",
   "heat_or_thermoregulation_section": "Warnings",
   "heat_or_thermoregulation_excerpt": "For this reason, it should be administered with caution during hot weather, especially when given concomitantly with other atropine-like drugs to the chronically ill, the alcoholic, those who have central nervous system disease, and those who do manual labor in a hot environment.",
   "decreased_sweating": true,
   "decreased_sweating_direct": true,
   "decreased_sweating_context": "warning",
   "decreased_sweating_section": "Warnings",
   "decreased_sweating_excerpt": "Since benztropine mesylate contains structural features of atropine, it may produce anhidrosis.",
   "sweating": false,
   "hyperthermia": true,
   "hyperthermia_direct": true,
   "hyperthermia_context": "heat exposure or thermoregulation",
   "hyperthermia_section": "Warnings",
   "hyperthermia_excerpt": "If there is evidence of anhidrosis, the possibility of hyperthermia should be considered.",
   "dehydration": false,
   "orthostatic_hypotension": false,
   "photosensitivity": false,
   "heat_kind": "less_sweating",
   "names_sauna_or_hot_tub": false,
   "storage": "Store at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature]."
  },
  {
   "drug": "glycopyrrolate (oral)",
   "generic": "glycopyrrolate",
   "class": "Anticholinergic",
   "group": "Anticholinergics and antihistamines",
   "label_title": "Glycopyrrolate / GLYCOPYRROLATE",
   "label_type": "Rx",
   "set_id": "2cda1ed5-10bb-4651-acbf-be44ad709665",
   "label_version": "1",
   "label_effective": "2026-02-12",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=2cda1ed5-10bb-4651-acbf-be44ad709665",
   "guide": null,
   "heat_or_thermoregulation": true,
   "heat_or_thermoregulation_direct": true,
   "heat_or_thermoregulation_context": "warning",
   "heat_or_thermoregulation_section": "Warnings and precautions",
   "heat_or_thermoregulation_excerpt": "( 5.4 , 7.1 ) Heat Prostration at High Environmental Temperatures : Heat prostration resulting in fever and heatstroke can occur, especially in geriatric patients.",
   "decreased_sweating": true,
   "decreased_sweating_direct": true,
   "decreased_sweating_context": "warning",
   "decreased_sweating_section": "Warnings and precautions",
   "decreased_sweating_excerpt": "5.5 Heat Prostration at High Environmental Temperatures In the presence of a high environmental temperature, heat prostration resulting in fever and heatstroke can occur with the use of glycopyrrolate tablets due to decreased sweating, particularly in geriatric patients [see Adverse Reactions ( 6 )] .",
   "sweating": false,
   "hyperthermia": true,
   "hyperthermia_direct": true,
   "hyperthermia_context": "heat exposure or thermoregulation",
   "hyperthermia_section": "Warnings and precautions",
   "hyperthermia_excerpt": "( 5.4 , 7.1 ) Heat Prostration at High Environmental Temperatures : Heat prostration resulting in fever and heatstroke can occur, especially in geriatric patients.",
   "dehydration": false,
   "orthostatic_hypotension": false,
   "photosensitivity": false,
   "heat_kind": "less_sweating",
   "names_sauna_or_hot_tub": false,
   "storage": "Store at controlled room temperature, 20°C to 25°C (68°F to 77°F); excursions permitted to 15°C to 30°C (59°F to 86°F) [see USP Controlled Room Temperature]."
  },
  {
   "drug": "hyoscyamine",
   "generic": "hyoscyamine",
   "class": "Anticholinergic (gut, bladder)",
   "group": "Anticholinergics and antihistamines",
   "label_title": "Hyoscyamine Sulfate / HYOSCYAMINE SULFATE",
   "label_type": "Rx",
   "set_id": "57b12b25-adea-c9bc-e063-6394a90aa925",
   "label_version": "1",
   "label_effective": "2026-07-29",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=57b12b25-adea-c9bc-e063-6394a90aa925",
   "guide": null,
   "heat_or_thermoregulation": true,
   "heat_or_thermoregulation_direct": true,
   "heat_or_thermoregulation_context": "warning",
   "heat_or_thermoregulation_section": "Warnings",
   "heat_or_thermoregulation_excerpt": "WARNINGS In the presence of high environmental temperature, heat prostration can occur with drug use (fever and heat stroke due to decreased sweating).",
   "decreased_sweating": true,
   "decreased_sweating_direct": true,
   "decreased_sweating_context": "warning",
   "decreased_sweating_section": "Warnings",
   "decreased_sweating_excerpt": "WARNINGS In the presence of high environmental temperature, heat prostration can occur with drug use (fever and heat stroke due to decreased sweating).",
   "sweating": false,
   "hyperthermia": true,
   "hyperthermia_direct": true,
   "hyperthermia_context": "heat exposure or thermoregulation",
   "hyperthermia_section": "Warnings",
   "hyperthermia_excerpt": "WARNINGS In the presence of high environmental temperature, heat prostration can occur with drug use (fever and heat stroke due to decreased sweating).",
   "dehydration": false,
   "orthostatic_hypotension": false,
   "photosensitivity": false,
   "heat_kind": "less_sweating",
   "names_sauna_or_hot_tub": false,
   "storage": "Store at controlled room temperature 20° to 25°C (68° to 77°F); excursion permitted to 15° to 30°C (59° to 86°F)."
  },
  {
   "drug": "tolterodine (Detrol)",
   "generic": "tolterodine",
   "class": "Antimuscarinic (bladder)",
   "group": "Anticholinergics and antihistamines",
   "label_title": "Tolterodine Tartrate / TOLTERODINE TARTRATE",
   "label_type": "Rx",
   "set_id": "b9ba8ad2-27f6-4f18-bd84-73659047910e",
   "label_version": "3",
   "label_effective": "2025-04-01",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=b9ba8ad2-27f6-4f18-bd84-73659047910e",
   "guide": null,
   "heat_or_thermoregulation": false,
   "decreased_sweating": false,
   "sweating": false,
   "hyperthermia": false,
   "dehydration": false,
   "orthostatic_hypotension": false,
   "photosensitivity": false,
   "heat_kind": null,
   "names_sauna_or_hot_tub": false,
   "storage": "Store at 25°C (77°F); excursions permitted to 15–30°C (59–86°F) [see USP Controlled Room Temperature] Manufactured by: Unique Pharmaceutical Laboratories (A Div."
  },
  {
   "drug": "solifenacin (Vesicare)",
   "generic": "solifenacin",
   "class": "Antimuscarinic (bladder)",
   "group": "Anticholinergics and antihistamines",
   "label_title": "Solifenacin succinate / SOLIFENACIN SUCCINATE",
   "label_type": "Rx",
   "set_id": "56026679-4002-a6c6-e063-6294a90a7b55",
   "label_version": "1",
   "label_effective": "2026-07-06",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=56026679-4002-a6c6-e063-6294a90a7b55",
   "guide": null,
   "heat_or_thermoregulation": true,
   "heat_or_thermoregulation_direct": true,
   "heat_or_thermoregulation_context": "patient advice",
   "heat_or_thermoregulation_section": "Patient counseling",
   "heat_or_thermoregulation_excerpt": "Heat prostration due to decreased sweating can occur when Solifenacin succinate tablets are used in a hot environment [see Adverse Reactions ( 6.2 )] .",
   "decreased_sweating": true,
   "decreased_sweating_direct": true,
   "decreased_sweating_context": "patient advice",
   "decreased_sweating_section": "Patient counseling",
   "decreased_sweating_excerpt": "Dry Skin Inform patients that Solifenacin succinate tablets, like other antimuscarinics, may cause dry skin due to decreased sweating.",
   "sweating": false,
   "hyperthermia": true,
   "hyperthermia_direct": true,
   "hyperthermia_context": "heat exposure or thermoregulation",
   "hyperthermia_section": "Patient information",
   "hyperthermia_excerpt": "Heat exhaustion or heat stroke can happen due to decreased sweating when solifenacin succinate tablets are used in hot environments.",
   "dehydration": false,
   "orthostatic_hypotension": false,
   "photosensitivity": false,
   "heat_kind": "less_sweating",
   "names_sauna_or_hot_tub": false,
   "storage": "Store at 20ºC to 25ºC (68ºF-77ºF) with excursions permitted from 15ºC to 30ºC (59°F-86ºF) [see USP Controlled Room Temperature]."
  },
  {
   "drug": "Benadryl",
   "generic": "diphenhydramine",
   "class": "Antihistamine (sedating)",
   "group": "Anticholinergics and antihistamines",
   "label_title": "Benadryl / DIPHENHYDRAMINE HYDROCHLORIDE",
   "label_type": "OTC",
   "set_id": "702f9786-7ce9-43e4-921d-e1db09612127",
   "label_version": "32",
   "label_effective": "2026-07-28",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=702f9786-7ce9-43e4-921d-e1db09612127",
   "guide": "https://www.tendground.com/journal/wellness-on-antihistamines-what-is-safe",
   "heat_or_thermoregulation": false,
   "decreased_sweating": false,
   "sweating": false,
   "hyperthermia": false,
   "dehydration": false,
   "orthostatic_hypotension": false,
   "photosensitivity": false,
   "heat_kind": null,
   "names_sauna_or_hot_tub": false,
   "storage": "store between 20-25°C (68-77°F)."
  },
  {
   "drug": "Unisom SleepTabs",
   "generic": "doxylamine",
   "class": "Antihistamine (sedating)",
   "group": "Anticholinergics and antihistamines",
   "label_title": "Unisom SleepTabs / DOXYLAMINE SUCCINATE",
   "label_type": "OTC",
   "set_id": "f591d52f-5610-4517-a96f-1ed63deb00bc",
   "label_version": "5",
   "label_effective": "2026-01-14",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=f591d52f-5610-4517-a96f-1ed63deb00bc",
   "guide": "https://www.tendground.com/journal/wellness-on-antihistamines-what-is-safe",
   "heat_or_thermoregulation": false,
   "decreased_sweating": false,
   "sweating": false,
   "hyperthermia": false,
   "dehydration": false,
   "orthostatic_hypotension": false,
   "photosensitivity": false,
   "heat_kind": null,
   "names_sauna_or_hot_tub": false,
   "storage": "Store at 20º to 25ºC (68 º-77 ºF) Keep carton."
  },
  {
   "drug": "hydroxyzine",
   "generic": "hydroxyzine",
   "class": "Antihistamine (sedating)",
   "group": "Anticholinergics and antihistamines",
   "label_title": "Hydroxyzine Hydrochloride / HYDROXYZINE HYDROCHLORIDE",
   "label_type": "Rx",
   "set_id": "9de2de56-614f-4294-8794-d30758cf5f70",
   "label_version": "2",
   "label_effective": "2026-03-03",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=9de2de56-614f-4294-8794-d30758cf5f70",
   "guide": "https://www.tendground.com/journal/wellness-on-antihistamines-what-is-safe",
   "heat_or_thermoregulation": false,
   "decreased_sweating": false,
   "sweating": false,
   "hyperthermia": false,
   "dehydration": false,
   "orthostatic_hypotension": false,
   "photosensitivity": false,
   "heat_kind": null,
   "names_sauna_or_hot_tub": false,
   "storage": "Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]."
  },
  {
   "drug": "Zyrtec",
   "generic": "cetirizine",
   "class": "Antihistamine",
   "group": "Anticholinergics and antihistamines",
   "label_title": "Zyrtec Allergy / CETIRIZINE HYDROCHLORIDE",
   "label_type": "OTC",
   "set_id": "b165db38-b302-4220-8627-77cb07bb078c",
   "label_version": "25",
   "label_effective": "2025-10-10",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=b165db38-b302-4220-8627-77cb07bb078c",
   "guide": "https://www.tendground.com/journal/wellness-on-antihistamines-what-is-safe",
   "heat_or_thermoregulation": false,
   "decreased_sweating": false,
   "sweating": false,
   "hyperthermia": false,
   "dehydration": false,
   "orthostatic_hypotension": false,
   "photosensitivity": false,
   "heat_kind": null,
   "names_sauna_or_hot_tub": false,
   "storage": null
  },
  {
   "drug": "Allegra-D",
   "generic": "fexofenadine and pseudoephedrine",
   "class": "Antihistamine and decongestant",
   "group": "Anticholinergics and antihistamines",
   "label_title": "Allegra-D Allergy and Congestion / FEXOFENADINE HYDROCHLORIDE AND PSEUDOEPHEDRINE HYDROCHLORIDE",
   "label_type": "OTC",
   "set_id": "1fb77d6a-fae2-40ae-8f8e-fa2dc66f4403",
   "label_version": "33",
   "label_effective": "2026-01-12",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=1fb77d6a-fae2-40ae-8f8e-fa2dc66f4403",
   "guide": "https://www.tendground.com/journal/wellness-on-antihistamines-what-is-safe",
   "heat_or_thermoregulation": false,
   "decreased_sweating": false,
   "sweating": false,
   "hyperthermia": false,
   "dehydration": false,
   "orthostatic_hypotension": false,
   "photosensitivity": false,
   "heat_kind": null,
   "names_sauna_or_hot_tub": false,
   "storage": null
  },
  {
   "drug": "Norvasc",
   "generic": "amlodipine",
   "class": "Blood pressure (calcium channel blocker)",
   "group": "Blood pressure and heart",
   "label_title": "Norvasc / AMLODIPINE BESYLATE",
   "label_type": "Rx",
   "set_id": "7367289c-b0b0-466a-83e2-558e2985c29f",
   "label_version": "10",
   "label_effective": "2023-02-15",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=7367289c-b0b0-466a-83e2-558e2985c29f",
   "guide": "https://www.tendground.com/journal/wellness-on-blood-pressure-medication-what-is-safe",
   "heat_or_thermoregulation": false,
   "decreased_sweating": false,
   "sweating": true,
   "sweating_direct": true,
   "sweating_context": "side effect",
   "sweating_section": "Adverse reactions",
   "sweating_excerpt": "Autonomic Nervous System: dry mouth, sweating increased.",
   "hyperthermia": false,
   "dehydration": false,
   "orthostatic_hypotension": false,
   "photosensitivity": false,
   "heat_kind": null,
   "names_sauna_or_hot_tub": false,
   "storage": "Store bottles at controlled room temperature, 59° to 86°F (15° to 30°C) and dispense in tight, light‑resistant containers (USP)."
  },
  {
   "drug": "Zestril",
   "generic": "lisinopril",
   "class": "Blood pressure (ACE inhibitor)",
   "group": "Blood pressure and heart",
   "label_title": "Zestril / LISINOPRIL",
   "label_type": "Rx",
   "set_id": "838c2d78-d2d8-4981-9ec9-e50ef9e1a5d8",
   "label_version": "2",
   "label_effective": "2025-01-02",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=838c2d78-d2d8-4981-9ec9-e50ef9e1a5d8",
   "guide": "https://www.tendground.com/journal/wellness-on-blood-pressure-medication-what-is-safe",
   "heat_or_thermoregulation": false,
   "decreased_sweating": false,
   "sweating": true,
   "sweating_direct": true,
   "sweating_context": "side effect",
   "sweating_section": "Adverse reactions",
   "sweating_excerpt": "Skin : Urticaria, alopecia, photosensitivity, erythema, flushing, diaphoresis, cutaneous pseudolymphoma, toxic epidermal necrolysis, Stevens - Johnson syndrome, and pruritus.",
   "hyperthermia": false,
   "dehydration": true,
   "dehydration_direct": true,
   "dehydration_context": "warning",
   "dehydration_section": "Warnings and precautions",
   "dehydration_excerpt": "Patients whose renal function may depend in part on the activity of the renin-angiotensin system (e.g., patients with renal artery stenosis, chronic kidney disease, severe congestive heart failure, post-myocardial infarction or volume depletion) may be at particular risk of developing acute renal failure on Zestril.",
   "orthostatic_hypotension": true,
   "orthostatic_hypotension_direct": true,
   "orthostatic_hypotension_context": "side effect",
   "orthostatic_hypotension_section": "Adverse reactions",
   "orthostatic_hypotension_excerpt": "…with Zestril in controlled clinical trials and do not appear in other sections of labeling are listed below: Body as a whole : Fatigue, asthenia, orthostatic effects. Digestive : Pancreatitis, constipation, flatulence, dry mouth, diarrhea. Hematologic : Rare cases of bone marrow depression, hemolytic anemia,…",
   "photosensitivity": true,
   "photosensitivity_direct": true,
   "photosensitivity_context": "side effect",
   "photosensitivity_section": "Adverse reactions",
   "photosensitivity_excerpt": "Skin : Urticaria, alopecia, photosensitivity, erythema, flushing, diaphoresis, cutaneous pseudolymphoma, toxic epidermal necrolysis, Stevens - Johnson syndrome, and pruritus.",
   "heat_kind": null,
   "names_sauna_or_hot_tub": false,
   "storage": "Store at controlled room temperature, 20° to 25°C (68° to 77°F) [see USP]."
  },
  {
   "drug": "Cozaar",
   "generic": "losartan",
   "class": "Blood pressure (ARB)",
   "group": "Blood pressure and heart",
   "label_title": "COZAAR / LOSARTAN POTASSIUM",
   "label_type": "Rx",
   "set_id": "9949448f-c3b9-44ee-94ed-c1aca8c90f39",
   "label_version": "9",
   "label_effective": "2026-01-20",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=9949448f-c3b9-44ee-94ed-c1aca8c90f39",
   "guide": "https://www.tendground.com/journal/wellness-on-blood-pressure-medication-what-is-safe",
   "heat_or_thermoregulation": false,
   "decreased_sweating": false,
   "sweating": false,
   "hyperthermia": false,
   "dehydration": true,
   "dehydration_direct": true,
   "dehydration_context": "warning",
   "dehydration_section": "Warnings and precautions",
   "dehydration_excerpt": "Patients whose renal function may depend in part on the activity of the renin-angiotensin system (e.g., patients with renal artery stenosis, chronic kidney disease, severe congestive heart failure, or volume depletion) may be at particular risk of developing acute renal failure on COZAAR.",
   "orthostatic_hypotension": true,
   "orthostatic_hypotension_direct": true,
   "orthostatic_hypotension_context": "side effect",
   "orthostatic_hypotension_section": "Adverse reactions",
   "orthostatic_hypotension_excerpt": "placebo on a background of conventional antihypertensive therapy, were asthenia/fatigue, chest pain, hypotension, orthostatic hypotension, diarrhea, anemia, hyperkalemia, hypoglycemia, back pain, muscular weakness, and urinary tract infection.",
   "photosensitivity": true,
   "photosensitivity_direct": true,
   "photosensitivity_context": "side effect",
   "photosensitivity_section": "Adverse reactions",
   "photosensitivity_excerpt": "Skin and subcutaneous tissue disorders: Urticaria, pruritus, rash, photosensitivity.",
   "heat_kind": null,
   "names_sauna_or_hot_tub": false,
   "storage": "Store at 25°C (77°F); excursions permitted to 15-30°C (59-86°F) [see USP Controlled Room Temperature]."
  },
  {
   "drug": "Toprol-XL",
   "generic": "metoprolol succinate",
   "class": "Blood pressure (beta blocker)",
   "group": "Blood pressure and heart",
   "label_title": "TOPROL XL / METOPROLOL SUCCINATE",
   "label_type": "Rx",
   "set_id": "496ddfaa-7c9c-4888-b747-a210249b367a",
   "label_version": "7",
   "label_effective": "2026-03-03",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=496ddfaa-7c9c-4888-b747-a210249b367a",
   "guide": "https://www.tendground.com/journal/wellness-on-blood-pressure-medication-what-is-safe",
   "heat_or_thermoregulation": false,
   "decreased_sweating": false,
   "sweating": true,
   "sweating_direct": true,
   "sweating_context": "side effect",
   "sweating_section": "Adverse reactions",
   "sweating_excerpt": "Miscellaneous: Musculoskeletal pain, arthralgia, blurred vision, decreased libido, male impotence, tinnitus, reversible alopecia, agranulocytosis, dry eyes, worsening of psoriasis, Peyronie's disease, sweating, photosensitivity, taste disturbance.",
   "hyperthermia": false,
   "dehydration": false,
   "orthostatic_hypotension": true,
   "orthostatic_hypotension_direct": false,
   "orthostatic_hypotension_context": "drug interaction",
   "orthostatic_hypotension_section": "Drug interactions",
   "orthostatic_hypotension_excerpt": "Observe patients treated with TOPROL-XL plus a catecholamine depletor for evidence of hypotension or marked bradycardia, which may produce vertigo, syncope, or postural hypotension.",
   "photosensitivity": true,
   "photosensitivity_direct": true,
   "photosensitivity_context": "side effect",
   "photosensitivity_section": "Adverse reactions",
   "photosensitivity_excerpt": "Miscellaneous: Musculoskeletal pain, arthralgia, blurred vision, decreased libido, male impotence, tinnitus, reversible alopecia, agranulocytosis, dry eyes, worsening of psoriasis, Peyronie's disease, sweating, photosensitivity, taste disturbance.",
   "heat_kind": null,
   "names_sauna_or_hot_tub": false,
   "storage": "Store at 25°C (77°F)."
  },
  {
   "drug": "propranolol",
   "generic": "propranolol",
   "class": "Beta blocker",
   "group": "Blood pressure and heart",
   "label_title": "Propranolol Hydrochloride / PROPRANOLOL HYDROCHLORIDE",
   "label_type": "Rx",
   "set_id": "14d0c95d-418f-40a8-bad3-e20c82424960",
   "label_version": "6",
   "label_effective": "2026-06-10",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=14d0c95d-418f-40a8-bad3-e20c82424960",
   "guide": "https://www.tendground.com/journal/wellness-on-blood-pressure-medication-what-is-safe",
   "heat_or_thermoregulation": false,
   "decreased_sweating": false,
   "sweating": false,
   "hyperthermia": false,
   "dehydration": false,
   "orthostatic_hypotension": true,
   "orthostatic_hypotension_direct": true,
   "orthostatic_hypotension_context": "warning",
   "orthostatic_hypotension_section": "Precautions",
   "orthostatic_hypotension_excerpt": "Postural hypotension has been reported in patients taking both beta-blockers and terazosin or doxazosin.",
   "photosensitivity": false,
   "heat_kind": null,
   "names_sauna_or_hot_tub": false,
   "storage": "Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]."
  },
  {
   "drug": "hydrochlorothiazide",
   "generic": "hydrochlorothiazide",
   "class": "Diuretic (thiazide)",
   "group": "Blood pressure and heart",
   "label_title": "Hydrochlorothiazide / HYDROCHLOROTHIAZIDE",
   "label_type": "Rx",
   "set_id": "33f3b980-b339-4dbf-99bd-05588c2a298c",
   "label_version": "12",
   "label_effective": "2025-06-13",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=33f3b980-b339-4dbf-99bd-05588c2a298c",
   "guide": "https://www.tendground.com/journal/wellness-on-blood-pressure-medication-what-is-safe",
   "heat_or_thermoregulation": true,
   "heat_or_thermoregulation_direct": true,
   "heat_or_thermoregulation_context": "warning",
   "heat_or_thermoregulation_section": "Precautions",
   "heat_or_thermoregulation_excerpt": "Dilutional hyponatremia may occur in edematous patients in hot weather; appropriate therapy is water restriction, rather than administration of salt, except in rare instances when the hyponatremia is life threatening.",
   "decreased_sweating": false,
   "sweating": false,
   "hyperthermia": false,
   "dehydration": true,
   "dehydration_direct": false,
   "dehydration_context": "overdose",
   "dehydration_section": "Overdosage",
   "dehydration_excerpt": "OVERDOSAGE The most common signs and symptoms observed are those caused by electrolyte depletion (hypokalemia, hypochloremia, hyponatremia) and dehydration resulting from excessive diuresis.",
   "orthostatic_hypotension": true,
   "orthostatic_hypotension_direct": true,
   "orthostatic_hypotension_context": "side effect",
   "orthostatic_hypotension_section": "Adverse reactions",
   "orthostatic_hypotension_excerpt": "Cardiovascular: Hypotension including orthostatic hypotension (may be aggravated by alcohol, barbiturates, narcotics or antihypertensive drugs).",
   "photosensitivity": true,
   "photosensitivity_direct": true,
   "photosensitivity_context": "side effect",
   "photosensitivity_section": "Adverse reactions",
   "photosensitivity_excerpt": "Hypersensitivity: Anaphylactic reactions, necrotizing angiitis (vasculitis and cutaneous vasculitis), respiratory distress including pneumonitis and pulmonary edema, photosensitivity, fever, urticaria, rash, purpura.",
   "heat_kind": "hot_weather",
   "names_sauna_or_hot_tub": false,
   "storage": "Store at 20° to 25° C (68° to 77° F) [see USP Controlled Room Temperature]."
  },
  {
   "drug": "Lasix",
   "generic": "furosemide",
   "class": "Diuretic (loop)",
   "group": "Blood pressure and heart",
   "label_title": "Lasix / FUROSEMIDE",
   "label_type": "Rx",
   "set_id": "2c9b4d8f-0770-482d-a9e6-9c616a440b1a",
   "label_version": "7",
   "label_effective": "2025-09-30",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=2c9b4d8f-0770-482d-a9e6-9c616a440b1a",
   "guide": "https://www.tendground.com/journal/wellness-on-blood-pressure-medication-what-is-safe",
   "heat_or_thermoregulation": false,
   "decreased_sweating": false,
   "sweating": true,
   "sweating_direct": false,
   "sweating_context": "drug interaction",
   "sweating_section": "Precautions",
   "sweating_excerpt": "In isolated cases, intravenous administration of LASIX within 24 hours of taking chloral hydrate may lead to flushing, sweating attacks, restlessness, nausea, increase in blood pressure, and tachycardia.",
   "hyperthermia": false,
   "dehydration": true,
   "dehydration_direct": true,
   "dehydration_context": "warning",
   "dehydration_section": "Precautions",
   "dehydration_excerpt": "PRECAUTIONS General Excessive diuresis may cause dehydration and blood volume reduction with circulatory collapse and possibly vascular thrombosis and embolism, particularly in elderly patients.",
   "orthostatic_hypotension": true,
   "orthostatic_hypotension_direct": true,
   "orthostatic_hypotension_context": "warning",
   "orthostatic_hypotension_section": "Precautions",
   "orthostatic_hypotension_excerpt": "The postural hypotension that sometimes occurs can usually be managed by getting up slowly.",
   "photosensitivity": true,
   "photosensitivity_direct": true,
   "photosensitivity_context": "warning",
   "photosensitivity_section": "Precautions",
   "photosensitivity_excerpt": "The skin of some patients may be more sensitive to the effects of sunlight while taking furosemide.",
   "heat_kind": null,
   "names_sauna_or_hot_tub": false,
   "storage": "Store at 68º to 77ºF (20º to 25ºC); excursions permitted to 59º to 86ºF (15º to 30ºC) [See USP Controlled Room Temperature]."
  },
  {
   "drug": "Aldactone",
   "generic": "spironolactone",
   "class": "Diuretic (potassium-sparing)",
   "group": "Blood pressure and heart",
   "label_title": "Aldactone / SPIRONOLACTONE",
   "label_type": "Rx",
   "set_id": "0fed2822-3a03-4b64-9857-c682fcd462bc",
   "label_version": "25",
   "label_effective": "2025-11-28",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=0fed2822-3a03-4b64-9857-c682fcd462bc",
   "guide": "https://www.tendground.com/journal/wellness-on-spironolactone-what-is-safe",
   "heat_or_thermoregulation": false,
   "decreased_sweating": false,
   "sweating": false,
   "hyperthermia": false,
   "dehydration": true,
   "dehydration_direct": true,
   "dehydration_context": "warning",
   "dehydration_section": "Warnings and precautions",
   "dehydration_excerpt": "5.2 Hypotension and Worsening Renal Function Excessive diuresis may cause symptomatic dehydration, hypotension and worsening renal function, particularly in salt-depleted patients or those taking angiotensin converting enzyme inhibitors and angiotensin II receptor blockers.",
   "orthostatic_hypotension": false,
   "photosensitivity": false,
   "heat_kind": null,
   "names_sauna_or_hot_tub": false,
   "storage": "Store below 77°F (25°C)."
  },
  {
   "drug": "clonidine (Catapres)",
   "generic": "clonidine",
   "class": "Blood pressure (central)",
   "group": "Blood pressure and heart",
   "label_title": "Clonidine hydrochloride / CLONIDINE HYDROCHLORIDE",
   "label_type": "Rx",
   "set_id": "c83e4e4f-bd0e-449d-958a-dc0d570a01ba",
   "label_version": "11",
   "label_effective": "2026-04-30",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=c83e4e4f-bd0e-449d-958a-dc0d570a01ba",
   "guide": "https://www.tendground.com/journal/wellness-on-blood-pressure-medication-what-is-safe",
   "heat_or_thermoregulation": false,
   "decreased_sweating": false,
   "sweating": false,
   "hyperthermia": false,
   "dehydration": false,
   "orthostatic_hypotension": true,
   "orthostatic_hypotension_direct": true,
   "orthostatic_hypotension_context": "warning",
   "orthostatic_hypotension_section": "Precautions",
   "orthostatic_hypotension_excerpt": "If a patient receiving clonidine is also taking neuroleptics, orthostatic regulation disturbances (e.g., orthostatic hypotension, dizziness, fatigue) may be induced or exacerbated.",
   "photosensitivity": false,
   "heat_kind": null,
   "names_sauna_or_hot_tub": false,
   "storage": "Store at 20° to 25°C (68° to 77°F)."
  },
  {
   "drug": "Viagra",
   "generic": "sildenafil",
   "class": "PDE5 inhibitor",
   "group": "Blood pressure and heart",
   "label_title": "Viagra / SILDENAFIL CITRATE",
   "label_type": "Rx",
   "set_id": "d905dc8d-917f-4ea3-a4ee-a1ecf6967d4e",
   "label_version": "6",
   "label_effective": "2023-11-17",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=d905dc8d-917f-4ea3-a4ee-a1ecf6967d4e",
   "guide": "https://www.tendground.com/journal/wellness-on-viagra-and-cialis-what-is-safe",
   "heat_or_thermoregulation": false,
   "decreased_sweating": false,
   "sweating": true,
   "sweating_direct": true,
   "sweating_context": "side effect",
   "sweating_section": "Adverse reactions",
   "sweating_excerpt": "Skin and Appendages: urticaria, herpes simplex, pruritus, sweating, skin ulcer, contact dermatitis, exfoliative dermatitis.",
   "hyperthermia": false,
   "dehydration": true,
   "dehydration_direct": true,
   "dehydration_context": "warning",
   "dehydration_section": "Warnings and precautions",
   "dehydration_excerpt": "Safety of combined use of PDE5 inhibitors and alpha-blockers may be affected by other variables, including intravascular volume depletion and other anti-hypertensive drugs.",
   "orthostatic_hypotension": true,
   "orthostatic_hypotension_direct": true,
   "orthostatic_hypotension_context": "side effect",
   "orthostatic_hypotension_section": "Adverse reactions",
   "orthostatic_hypotension_excerpt": "Cardiovascular: angina pectoris, AV block, migraine, syncope, tachycardia, palpitation, hypotension, postural hypotension, myocardial ischemia, cerebral thrombosis, cardiac arrest, heart failure, abnormal electrocardiogram, cardiomyopathy.",
   "photosensitivity": true,
   "photosensitivity_direct": true,
   "photosensitivity_context": "side effect",
   "photosensitivity_section": "Adverse reactions",
   "photosensitivity_excerpt": "Reported events include those with a plausible relation to drug use; omitted are minor events and reports too imprecise to be meaningful: Body as a Whole: face edema, photosensitivity reaction, shock, asthenia, pain, chills, accidental fall, abdominal pain, allergic reaction, chest pain, accidental injury.",
   "heat_kind": null,
   "names_sauna_or_hot_tub": false,
   "storage": "Store at 25°C (77°F); excursions permitted to 15-30°C (59-86°F) [see USP Controlled Room Temperature]."
  },
  {
   "drug": "Cialis",
   "generic": "tadalafil",
   "class": "PDE5 inhibitor",
   "group": "Blood pressure and heart",
   "label_title": "Cialis / TADALAFIL",
   "label_type": "Rx",
   "set_id": "bcd8f8ab-81a2-4891-83db-24a0b0e25895",
   "label_version": "52",
   "label_effective": "2026-06-03",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=bcd8f8ab-81a2-4891-83db-24a0b0e25895",
   "guide": "https://www.tendground.com/journal/wellness-on-viagra-and-cialis-what-is-safe",
   "heat_or_thermoregulation": false,
   "decreased_sweating": false,
   "sweating": true,
   "sweating_direct": true,
   "sweating_context": "side effect",
   "sweating_section": "Adverse reactions",
   "sweating_excerpt": "…somnolence, vertigo Renal and Urinary — renal impairment Respiratory — dyspnea, epistaxis, pharyngitis Skin and Appendages — pruritus, rash, sweating Ophthalmologic — blurred vision, changes in color vision, conjunctivitis (including conjunctival hyperemia), eye pain, lacrimation increase,…",
   "hyperthermia": false,
   "dehydration": true,
   "dehydration_direct": true,
   "dehydration_context": "warning",
   "dehydration_section": "Warnings and precautions",
   "dehydration_excerpt": "Safety of combined use of PDE5 inhibitors and alpha-blockers may be affected by other variables, including intravascular volume depletion and other antihypertensive drugs.",
   "orthostatic_hypotension": true,
   "orthostatic_hypotension_direct": true,
   "orthostatic_hypotension_context": "side effect",
   "orthostatic_hypotension_section": "Adverse reactions",
   "orthostatic_hypotension_excerpt": "…as a Whole — asthenia, face edema, fatigue, pain, peripheral edema Cardiovascular — angina pectoris, chest pain, hypotension, myocardial infarction, postural hypotension, palpitations, syncope, tachycardia Digestive — abnormal liver function tests, dry mouth, dysphagia, esophagitis, gastritis, GGTP increased, loose…",
   "photosensitivity": false,
   "heat_kind": null,
   "names_sauna_or_hot_tub": false,
   "storage": "Store at 25°C (77°F); excursions permitted to 15-30°C (59-86°F) [see USP Controlled Room Temperature]."
  },
  {
   "drug": "Lipitor",
   "generic": "atorvastatin",
   "class": "Statin",
   "group": "Blood pressure and heart",
   "label_title": "Lipitor / ATORVASTATIN CALCIUM",
   "label_type": "Rx",
   "set_id": "a60cc18b-0631-4cf0-b021-9f52224ece65",
   "label_version": "8",
   "label_effective": "2024-04-15",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=a60cc18b-0631-4cf0-b021-9f52224ece65",
   "guide": "https://www.tendground.com/journal/wellness-on-statins-what-is-safe",
   "heat_or_thermoregulation": false,
   "decreased_sweating": false,
   "sweating": false,
   "hyperthermia": false,
   "dehydration": false,
   "orthostatic_hypotension": false,
   "photosensitivity": false,
   "heat_kind": null,
   "names_sauna_or_hot_tub": false,
   "storage": "Store at controlled room temperature 20-25°C (68-77°F)."
  },
  {
   "drug": "Eliquis",
   "generic": "apixaban",
   "class": "Anticoagulant",
   "group": "Blood thinners",
   "label_title": "Eliquis / apixaban",
   "label_type": "Rx",
   "set_id": "ca70b23e-6f02-43a8-9c88-9550c0d230cf",
   "label_version": "102",
   "label_effective": "2026-01-30",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=ca70b23e-6f02-43a8-9c88-9550c0d230cf",
   "guide": "https://www.tendground.com/journal/wellness-on-blood-thinners-what-is-safe",
   "heat_or_thermoregulation": false,
   "decreased_sweating": false,
   "sweating": false,
   "hyperthermia": false,
   "dehydration": false,
   "orthostatic_hypotension": false,
   "photosensitivity": false,
   "heat_kind": null,
   "names_sauna_or_hot_tub": false,
   "storage": null
  },
  {
   "drug": "Xarelto",
   "generic": "rivaroxaban",
   "class": "Anticoagulant",
   "group": "Blood thinners",
   "label_title": "Xarelto / RIVAROXABAN",
   "label_type": "Rx",
   "set_id": "10db92f9-2300-4a80-836b-673e1ae91610",
   "label_version": "65",
   "label_effective": "2026-09-10",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=10db92f9-2300-4a80-836b-673e1ae91610",
   "guide": "https://www.tendground.com/journal/wellness-on-blood-thinners-what-is-safe",
   "heat_or_thermoregulation": false,
   "decreased_sweating": false,
   "sweating": false,
   "hyperthermia": false,
   "dehydration": false,
   "orthostatic_hypotension": false,
   "photosensitivity": false,
   "heat_kind": null,
   "names_sauna_or_hot_tub": false,
   "storage": "Store at room temperature between 20 °C to 25 °C (68 °F to 77 °F); excursions permitted between 15 °C to 30 °C (59 °F to 86 °F) [see USP Controlled Room Temperature]."
  },
  {
   "drug": "warfarin",
   "generic": "warfarin",
   "class": "Anticoagulant",
   "group": "Blood thinners",
   "label_title": "Jantoven / WARFARIN SODIUM",
   "label_type": "Rx",
   "set_id": "19a69a72-ac5d-45d5-a94d-a5aaecbe4730",
   "label_version": "13",
   "label_effective": "2025-07-08",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=19a69a72-ac5d-45d5-a94d-a5aaecbe4730",
   "guide": "https://www.tendground.com/journal/wellness-on-blood-thinners-what-is-safe",
   "heat_or_thermoregulation": false,
   "decreased_sweating": false,
   "sweating": false,
   "hyperthermia": false,
   "dehydration": false,
   "orthostatic_hypotension": false,
   "photosensitivity": false,
   "heat_kind": null,
   "names_sauna_or_hot_tub": false,
   "storage": "Store at 20° to 25°C (68° to 77°F)."
  },
  {
   "drug": "metformin",
   "generic": "metformin",
   "class": "Diabetes",
   "group": "Diabetes and weight",
   "label_title": "Metformin Hydrochloride / METFORMIN HYDROCHLORIDE",
   "label_type": "Rx",
   "set_id": "082b4de9-e452-fe71-e063-6394a90ac863",
   "label_version": "6",
   "label_effective": "2025-10-28",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=082b4de9-e452-fe71-e063-6394a90ac863",
   "guide": "https://www.tendground.com/journal/wellness-on-metformin-jardiance-or-farxiga-what-is-safe",
   "heat_or_thermoregulation": false,
   "decreased_sweating": false,
   "sweating": true,
   "sweating_direct": true,
   "sweating_context": "side effect",
   "sweating_section": "Adverse reactions",
   "sweating_excerpt": "…tablets treated patients and were more commonly reported with metformin hydrochloride tablets than placebo: abnormal stools, hypoglycemia, myalgia, lightheaded, dyspnea, nail disorder, rash, sweating increased, taste disorder, chest discomfort, chills, flu syndrome, flushing, palpitation.",
   "hyperthermia": false,
   "dehydration": true,
   "dehydration_direct": true,
   "dehydration_context": "warning",
   "dehydration_section": "Warnings and precautions",
   "dehydration_excerpt": "Surgery and other procedures — Withholding of food and fluids during surgical or other procedures may increase the risk for volume depletion, hypotension, and renal impairment.",
   "orthostatic_hypotension": false,
   "photosensitivity": false,
   "heat_kind": null,
   "names_sauna_or_hot_tub": false,
   "storage": "Store at 20° to 25°C (68° to 77°F); excursions permitted from 15° to 30°C (59° to 86°F)."
  },
  {
   "drug": "Jardiance",
   "generic": "empagliflozin",
   "class": "Diabetes / heart failure (SGLT2)",
   "group": "Diabetes and weight",
   "label_title": "Jardiance / EMPAGLIFLOZIN",
   "label_type": "Rx",
   "set_id": "faf3dd6a-9cd0-39c2-0d2e-232cb3f67565",
   "label_version": "31",
   "label_effective": "2026-01-30",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=faf3dd6a-9cd0-39c2-0d2e-232cb3f67565",
   "guide": "https://www.tendground.com/journal/wellness-on-metformin-jardiance-or-farxiga-what-is-safe",
   "heat_or_thermoregulation": false,
   "decreased_sweating": false,
   "sweating": true,
   "sweating_direct": false,
   "sweating_context": "low blood sugar symptom",
   "sweating_section": "Medication Guide",
   "sweating_excerpt": "Signs and symptoms of low blood sugar may include: headache drowsiness weakness irritability hunger fast heartbeat confusion shaking or feeling jittery dizziness sweating Amputations.",
   "hyperthermia": false,
   "dehydration": true,
   "dehydration_direct": true,
   "dehydration_context": "warning",
   "dehydration_section": "Warnings and precautions",
   "dehydration_excerpt": "( 5.1 ) Volume Depletion: Before initiating JARDIANCE, assess volume status and renal function in patients with impaired renal function, elderly patients, or patients on loop diuretics.",
   "orthostatic_hypotension": true,
   "orthostatic_hypotension_direct": true,
   "orthostatic_hypotension_context": "patient advice",
   "orthostatic_hypotension_section": "Medication Guide",
   "orthostatic_hypotension_excerpt": "Dehydration may cause you to feel dizzy, faint, light-headed, or weak, especially when you stand up (orthostatic hypotension).",
   "photosensitivity": false,
   "heat_kind": null,
   "names_sauna_or_hot_tub": false,
   "storage": "Store at 20°C to 25°C (68°F to 77°F); excursions permitted to 15°C to 30°C (59°F to 86°F) [see USP Controlled Room Temperature]."
  },
  {
   "drug": "Farxiga",
   "generic": "dapagliflozin",
   "class": "Diabetes / heart failure / kidney (SGLT2)",
   "group": "Diabetes and weight",
   "label_title": "FARXIGA / DAPAGLIFLOZIN",
   "label_type": "Rx",
   "set_id": "72ad22ae-efe6-4cd6-a302-98aaee423d69",
   "label_version": "49",
   "label_effective": "2026-06-03",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=72ad22ae-efe6-4cd6-a302-98aaee423d69",
   "guide": "https://www.tendground.com/journal/wellness-on-metformin-jardiance-or-farxiga-what-is-safe",
   "heat_or_thermoregulation": false,
   "decreased_sweating": false,
   "sweating": true,
   "sweating_direct": false,
   "sweating_context": "low blood sugar symptom",
   "sweating_section": "Medication Guide",
   "sweating_excerpt": "Signs and symptoms of low blood sugar may include: ∘ headache ∘ drowsiness ∘ weakness ∘ confusion ∘ dizziness ∘ sweating…",
   "hyperthermia": false,
   "dehydration": true,
   "dehydration_direct": true,
   "dehydration_context": "warning",
   "dehydration_section": "Warnings and precautions",
   "dehydration_excerpt": "Volume depletion: Before initiating FARXIGA, assess volume status and renal function in the elderly, patients with renal impairment or low systolic blood pressure, and in patients on diuretics.",
   "orthostatic_hypotension": true,
   "orthostatic_hypotension_direct": true,
   "orthostatic_hypotension_context": "patient advice",
   "orthostatic_hypotension_section": "Medication Guide",
   "orthostatic_hypotension_excerpt": "Dehydration may cause you to feel dizzy, faint, lightheaded, or weak, especially when you stand up (orthostatic hypotension).",
   "photosensitivity": false,
   "heat_kind": null,
   "names_sauna_or_hot_tub": false,
   "storage": "Store at 20°C to 25°C (68°F to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F) [see USP Controlled Room Temperature]."
  },
  {
   "drug": "Ozempic",
   "generic": "semaglutide",
   "class": "GLP-1 (diabetes)",
   "group": "Diabetes and weight",
   "label_title": "Ozempic / semaglutide",
   "label_type": "Rx",
   "set_id": "adec4fd2-6858-4c99-91d4-531f5f2a2d79",
   "label_version": "20",
   "label_effective": "2026-06-01",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=adec4fd2-6858-4c99-91d4-531f5f2a2d79",
   "guide": "https://www.tendground.com/journal/wellness-on-ozempic-wegovy-or-mounjaro-what-is-safe",
   "heat_or_thermoregulation": false,
   "decreased_sweating": false,
   "sweating": true,
   "sweating_direct": false,
   "sweating_context": "low blood sugar symptom",
   "sweating_section": "Medication Guide",
   "sweating_excerpt": "Signs and symptoms of low blood sugar may include: o dizziness or light-headedness o blurred vision o anxiety, irritability, or mood changes o sweating o slurred speech o hunger o confusion or drowsiness o shakiness o weakness o headache o fast heartbeat o feeling jittery…",
   "hyperthermia": false,
   "dehydration": true,
   "dehydration_direct": true,
   "dehydration_context": "warning",
   "dehydration_section": "Warnings and precautions",
   "dehydration_excerpt": "Acute Kidney Injury Due to Volume Depletion: Monitor renal function in patients reporting adverse reactions that could lead to volume depletion.",
   "orthostatic_hypotension": false,
   "photosensitivity": false,
   "heat_kind": null,
   "names_sauna_or_hot_tub": false,
   "storage": "stored in a refrigerator between 2°C to 8°C (36°F to 46°F)."
  },
  {
   "drug": "Wegovy",
   "generic": "semaglutide",
   "class": "GLP-1 (weight)",
   "group": "Diabetes and weight",
   "label_title": "Wegovy / semaglutide",
   "label_type": "Rx",
   "set_id": "ee06186f-2aa3-4990-a760-757579d8f77b",
   "label_version": "19",
   "label_effective": "2026-06-18",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=ee06186f-2aa3-4990-a760-757579d8f77b",
   "guide": "https://www.tendground.com/journal/wellness-on-ozempic-wegovy-or-mounjaro-what-is-safe",
   "heat_or_thermoregulation": false,
   "decreased_sweating": false,
   "sweating": true,
   "sweating_direct": false,
   "sweating_context": "low blood sugar symptom",
   "sweating_section": "Medication Guide",
   "sweating_excerpt": "Signs and symptoms of low blood sugar may include: o dizziness or light-headedness o sweating o shakiness o blurred vision o slurred speech o weakness o anxiety o hunger o headache o irritability or mood changes o confusion or drowsiness o fast heartbeat o feeling jittery…",
   "hyperthermia": false,
   "dehydration": true,
   "dehydration_direct": true,
   "dehydration_context": "warning",
   "dehydration_section": "Warnings and precautions",
   "dehydration_excerpt": "Acute Kidney Injury Due to Volume Depletion : Monitor renal function in patients reporting adverse reactions that could lead to volume depletion.",
   "orthostatic_hypotension": true,
   "orthostatic_hypotension_direct": true,
   "orthostatic_hypotension_context": "side effect",
   "orthostatic_hypotension_section": "Adverse reactions",
   "orthostatic_hypotension_excerpt": "Hypotension and Syncope Adverse reactions related to hypotension (hypotension, orthostatic hypotension, and decreased blood pressure) were reported in 1.3% of WEGOVY-treated adult patients versus 0.4% of placebo-treated patients and syncope was reported in 0.8% of WEGOVY-treated patients versus 0.2%…",
   "photosensitivity": false,
   "heat_kind": null,
   "names_sauna_or_hot_tub": false,
   "storage": "Store the WEGOVY prefilled single-dose pen or single-dose syringe in the refrigerator from 2°C to 8°C (36°F to 46°F)."
  },
  {
   "drug": "Mounjaro",
   "generic": "tirzepatide",
   "class": "GLP-1/GIP (diabetes)",
   "group": "Diabetes and weight",
   "label_title": "Mounjaro / TIRZEPATIDE",
   "label_type": "Rx",
   "set_id": "d2d7da5d-ad07-4228-955f-cf7e355c8cc0",
   "label_version": "40",
   "label_effective": "2026-08-27",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=d2d7da5d-ad07-4228-955f-cf7e355c8cc0",
   "guide": "https://www.tendground.com/journal/wellness-on-ozempic-wegovy-or-mounjaro-what-is-safe",
   "heat_or_thermoregulation": false,
   "decreased_sweating": false,
   "sweating": true,
   "sweating_direct": false,
   "sweating_context": "low blood sugar symptom",
   "sweating_section": "Medication Guide",
   "sweating_excerpt": "Signs and symptoms of low blood sugar may include: dizziness or light-headedness sweating confusion or drowsiness headache blurred vision slurred speech shakiness fast heartbeat anxiety, irritability, or mood changes hunger weakness feeling jittery serious allergic reactions.",
   "hyperthermia": false,
   "dehydration": true,
   "dehydration_direct": true,
   "dehydration_context": "warning",
   "dehydration_section": "Warnings and precautions",
   "dehydration_excerpt": "( 5.4 ) Acute Kidney Injury Due to Volume Depletion: Monitor renal function in patients reporting adverse reactions that could lead to volume depletion.",
   "orthostatic_hypotension": false,
   "photosensitivity": false,
   "heat_kind": null,
   "names_sauna_or_hot_tub": false,
   "storage": "Store MOUNJARO single-dose pen and single-dose vial in a refrigerator at 2°C to 8°C (36°F to 46°F)."
  },
  {
   "drug": "Zepbound",
   "generic": "tirzepatide",
   "class": "GLP-1/GIP (weight)",
   "group": "Diabetes and weight",
   "label_title": "Zepbound / TIRZEPATIDE",
   "label_type": "Rx",
   "set_id": "487cd7e7-434c-4925-99fa-aa80b1cc776b",
   "label_version": "40",
   "label_effective": "2026-08-28",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=487cd7e7-434c-4925-99fa-aa80b1cc776b",
   "guide": "https://www.tendground.com/journal/wellness-on-ozempic-wegovy-or-mounjaro-what-is-safe",
   "heat_or_thermoregulation": false,
   "decreased_sweating": false,
   "sweating": true,
   "sweating_direct": false,
   "sweating_context": "low blood sugar symptom",
   "sweating_section": "Medication Guide",
   "sweating_excerpt": "Signs and symptoms of low blood sugar may include: dizziness or light-headedness sweating confusion or drowsiness headache blurred vision slurred speech shakiness fast heartbeat anxiety, irritability, or mood changes hunger weakness feeling jittery changes in vision in patients with type 2 diabetes.",
   "hyperthermia": false,
   "dehydration": true,
   "dehydration_direct": true,
   "dehydration_context": "warning",
   "dehydration_section": "Warnings and precautions",
   "dehydration_excerpt": "( 5.2 ) Acute Kidney Injury Due to Volume Depletion: Monitor renal function in patients reporting adverse reactions that could lead to volume depletion.",
   "orthostatic_hypotension": true,
   "orthostatic_hypotension_direct": true,
   "orthostatic_hypotension_context": "side effect",
   "orthostatic_hypotension_section": "Adverse reactions",
   "orthostatic_hypotension_excerpt": "f Includes blood pressure decreased, hypotension, orthostatic hypotension.",
   "photosensitivity": false,
   "heat_kind": null,
   "names_sauna_or_hot_tub": false,
   "storage": "Store ZEPBOUND single-dose pen and single-dose vial in a refrigerator at 2°C to 8°C (36°F to 46°F)."
  },
  {
   "drug": "Humalog",
   "generic": "insulin lispro",
   "class": "Insulin",
   "group": "Diabetes and weight",
   "label_title": "Humalog / INSULIN LISPRO",
   "label_type": "Rx",
   "set_id": "c8ecbd7a-0e22-4fc7-a503-faa58c1b6f3f",
   "label_version": "87",
   "label_effective": "2026-06-16",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=c8ecbd7a-0e22-4fc7-a503-faa58c1b6f3f",
   "guide": "https://www.tendground.com/journal/sauna-and-hot-tub-with-a-cgm-or-insulin-pump",
   "heat_or_thermoregulation": true,
   "heat_or_thermoregulation_direct": true,
   "heat_or_thermoregulation_context": "patient advice",
   "heat_or_thermoregulation_section": "Patient counseling",
   "heat_or_thermoregulation_excerpt": "Instruct patients to discard insulin exposed to temperatures higher than 98.6°F (37°C). The temperature of the insulin may exceed ambient temperature when the pump housing, cover, tubing or sport case is exposed to sunlight or radiant heat.",
   "decreased_sweating": false,
   "sweating": true,
   "sweating_direct": true,
   "sweating_context": "side effect",
   "sweating_section": "Adverse reactions",
   "sweating_excerpt": "Generalized allergy to insulin may cause whole body rash (including pruritus), dyspnea, wheezing, hypotension, tachycardia, or diaphoresis.",
   "hyperthermia": false,
   "dehydration": false,
   "orthostatic_hypotension": false,
   "photosensitivity": false,
   "heat_kind": "drug_or_device",
   "names_sauna_or_hot_tub": false,
   "storage": "stored for 28 days when refrigerated at 41°F (5°C) and for 14 days at room temperature up to 86°F (30°C) [see Dosage and Administration ( 2."
  },
  {
   "drug": "Synthroid",
   "generic": "levothyroxine",
   "class": "Thyroid hormone",
   "group": "Diabetes and weight",
   "label_title": "Synthroid / LEVOTHYROXINE SODIUM",
   "label_type": "Rx",
   "set_id": "1e11ad30-1041-4520-10b0-8f9d30d30fcc",
   "label_version": "1537",
   "label_effective": "2024-02-20",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=1e11ad30-1041-4520-10b0-8f9d30d30fcc",
   "guide": "https://www.tendground.com/journal/wellness-on-levothyroxine-synthroid-what-is-safe",
   "heat_or_thermoregulation": true,
   "heat_or_thermoregulation_direct": false,
   "heat_or_thermoregulation_context": "too much thyroid hormone",
   "heat_or_thermoregulation_section": "Adverse reactions",
   "heat_or_thermoregulation_excerpt": "Adverse reactions associated with SYNTHROID therapy are primarily those of hyperthyroidism due to therapeutic overdosage … General: fatigue, increased appetite, weight loss, heat intolerance, fever, excessive sweating",
   "decreased_sweating": false,
   "sweating": true,
   "sweating_direct": false,
   "sweating_context": "too much thyroid hormone",
   "sweating_section": "Adverse reactions",
   "sweating_excerpt": "Adverse reactions associated with SYNTHROID therapy are primarily those of hyperthyroidism due to therapeutic overdosage … General: fatigue, increased appetite, weight loss, heat intolerance, fever, excessive sweating",
   "hyperthermia": false,
   "dehydration": false,
   "orthostatic_hypotension": false,
   "photosensitivity": false,
   "heat_kind": "heat_intolerance",
   "names_sauna_or_hot_tub": false,
   "storage": "Store SYNTHROID at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F) (see USP Controlled Room Temperature)."
  },
  {
   "drug": "Claravis",
   "generic": "isotretinoin",
   "class": "Retinoid (oral, acne)",
   "group": "Skin, hair, hormones and antibiotics",
   "label_title": "Claravis / ISOTRETINOIN",
   "label_type": "Rx",
   "set_id": "a31fd109-d0fd-4ab9-ba98-a3d64333c18d",
   "label_version": "19",
   "label_effective": "2026-07-22",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=a31fd109-d0fd-4ab9-ba98-a3d64333c18d",
   "guide": "https://www.tendground.com/journal/wellness-on-isotretinoin-accutane-what-is-safe",
   "heat_or_thermoregulation": false,
   "decreased_sweating": false,
   "sweating": true,
   "sweating_direct": true,
   "sweating_context": "side effect",
   "sweating_section": "Adverse reactions",
   "sweating_excerpt": "…reactions, pruritus, pyogenic granuloma, rash (including facial erythema, seborrhea, and eczema), skin fragility, Stevens-Johnson syndrome, sunburn, sweating, toxic epidermal necrolysis, urticaria, vasculitis (including granulomatosis with polyangiitis), wound healing abnormal (delayed healing or…",
   "hyperthermia": false,
   "dehydration": false,
   "orthostatic_hypotension": false,
   "photosensitivity": true,
   "photosensitivity_direct": true,
   "photosensitivity_context": "patient advice",
   "photosensitivity_section": "Medication Guide",
   "photosensitivity_excerpt": "Avoid sunlight and ultraviolet lights as much as possible. Tanning machines use ultraviolet lights. Claravis may make your skin more sensitive to light.",
   "heat_kind": null,
   "names_sauna_or_hot_tub": false,
   "storage": "Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]."
  },
  {
   "drug": "Retin-A Micro",
   "generic": "tretinoin",
   "class": "Retinoid (topical)",
   "group": "Skin, hair, hormones and antibiotics",
   "label_title": "Retin-A MICRO / TRETINOIN",
   "label_type": "Rx",
   "set_id": "08ab7e0c-1437-455f-815c-98904d96a289",
   "label_version": "23",
   "label_effective": "2025-09-01",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=08ab7e0c-1437-455f-815c-98904d96a289",
   "guide": "https://www.tendground.com/journal/wellness-on-tretinoin-and-retinoids-what-is-safe",
   "heat_or_thermoregulation": false,
   "decreased_sweating": false,
   "sweating": false,
   "hyperthermia": false,
   "dehydration": false,
   "orthostatic_hypotension": false,
   "photosensitivity": true,
   "photosensitivity_direct": true,
   "photosensitivity_context": "warning",
   "photosensitivity_section": "Warnings and precautions",
   "photosensitivity_excerpt": "Photosensitivity : RETIN-A MICRO can cause photosensitivity.",
   "heat_kind": null,
   "names_sauna_or_hot_tub": false,
   "storage": "Store at 20° to 25°C (68° to 77°F); excursions permitted from 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature]."
  },
  {
   "drug": "Tazorac",
   "generic": "tazarotene",
   "class": "Retinoid (topical)",
   "group": "Skin, hair, hormones and antibiotics",
   "label_title": "TAZORAC / TAZAROTENE",
   "label_type": "Rx",
   "set_id": "021744d1-a6d7-4ad6-99c2-7187c24e64c6",
   "label_version": "6",
   "label_effective": "2025-11-13",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=021744d1-a6d7-4ad6-99c2-7187c24e64c6",
   "guide": "https://www.tendground.com/journal/wellness-on-tretinoin-and-retinoids-what-is-safe",
   "heat_or_thermoregulation": false,
   "decreased_sweating": false,
   "sweating": false,
   "hyperthermia": false,
   "dehydration": false,
   "orthostatic_hypotension": false,
   "photosensitivity": true,
   "photosensitivity_direct": true,
   "photosensitivity_context": "warning",
   "photosensitivity_section": "Warnings and precautions",
   "photosensitivity_excerpt": "( 5.2 ) Photosensitivity and Risk for Sunburn: Avoid exposure to sunlight, sunlamps, and weather extremes.",
   "heat_kind": null,
   "names_sauna_or_hot_tub": false,
   "storage": "Store at 20°C to 25°C (68°F to 77°F)."
  },
  {
   "drug": "Doryx MPC",
   "generic": "doxycycline",
   "class": "Antibiotic (tetracycline)",
   "group": "Skin, hair, hormones and antibiotics",
   "label_title": "DORYX MPC / DOXYCYCLINE HYCLATE",
   "label_type": "Rx",
   "set_id": "f9277bb8-982d-444d-9325-35d5c53a2d35",
   "label_version": "15",
   "label_effective": "2026-02-16",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=f9277bb8-982d-444d-9325-35d5c53a2d35",
   "guide": "https://www.tendground.com/journal/wellness-on-doxycycline-and-antibiotics-what-is-safe",
   "heat_or_thermoregulation": false,
   "decreased_sweating": false,
   "sweating": false,
   "hyperthermia": false,
   "dehydration": false,
   "orthostatic_hypotension": false,
   "photosensitivity": true,
   "photosensitivity_direct": true,
   "photosensitivity_context": "warning",
   "photosensitivity_section": "Warnings and precautions",
   "photosensitivity_excerpt": "( 5.2 ) Photosensitivity manifested by an exaggerated sunburn reaction has been observed in some individuals taking tetracyclines.",
   "heat_kind": null,
   "names_sauna_or_hot_tub": false,
   "storage": "Store at 25° C (77° F); excursions permitted to 15°C to 30° C (59°F to 86° F) [see USP Controlled Room Temperature]."
  },
  {
   "drug": "ciprofloxacin",
   "generic": "ciprofloxacin",
   "class": "Antibiotic (fluoroquinolone)",
   "group": "Skin, hair, hormones and antibiotics",
   "label_title": "Ciprofloxacin / CIPROFLOXACIN HYDROCHLORIDE",
   "label_type": "Rx",
   "set_id": "6a935846-3c97-4517-bc4e-2377f673285e",
   "label_version": "3",
   "label_effective": "2026-05-11",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=6a935846-3c97-4517-bc4e-2377f673285e",
   "guide": "https://www.tendground.com/journal/wellness-on-doxycycline-and-antibiotics-what-is-safe",
   "heat_or_thermoregulation": false,
   "decreased_sweating": false,
   "sweating": true,
   "sweating_direct": true,
   "sweating_context": "side effect",
   "sweating_section": "Adverse reactions",
   "sweating_excerpt": "…Dermatitis Toxic Epidermal Necrolysis Pruritus Urticaria Photosensitivity/Phototoxicity reaction Flushing Fever Angioedema Erythema Nodosum Sweating Special Senses Blurred Vision Disturbed Vision (chromatopsia and photopsia) Decreased Visual Acuity Diplopia Tinnitus Hearing Loss Bad Taste In…",
   "hyperthermia": false,
   "dehydration": false,
   "orthostatic_hypotension": false,
   "photosensitivity": true,
   "photosensitivity_direct": true,
   "photosensitivity_context": "warning",
   "photosensitivity_section": "Warnings and precautions",
   "photosensitivity_excerpt": "5.14 Photosensitivity/Phototoxicity Moderate to severe photosensitivity/phototoxicity reactions, the latter of which may manifest as exaggerated sunburn reactions (for example, burning, erythema, exudation, vesicles,…",
   "heat_kind": null,
   "names_sauna_or_hot_tub": false,
   "storage": "Store at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature]."
  },
  {
   "drug": "minoxidil tablets",
   "generic": "minoxidil (oral)",
   "class": "Blood pressure / hair loss (oral)",
   "group": "Skin, hair, hormones and antibiotics",
   "label_title": "Minoxidil / MINOXIDIL",
   "label_type": "Rx",
   "set_id": "8f3800f0-b6da-4dfe-8c32-39bb5eb0262a",
   "label_version": "11",
   "label_effective": "2026-06-11",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=8f3800f0-b6da-4dfe-8c32-39bb5eb0262a",
   "guide": "https://www.tendground.com/journal/wellness-on-minoxidil-what-is-safe",
   "heat_or_thermoregulation": false,
   "decreased_sweating": false,
   "sweating": false,
   "hyperthermia": false,
   "dehydration": false,
   "orthostatic_hypotension": true,
   "orthostatic_hypotension_direct": true,
   "orthostatic_hypotension_context": "warning",
   "orthostatic_hypotension_section": "Boxed warning",
   "orthostatic_hypotension_excerpt": "Patients with malignant hypertension and those already receiving guanethidine (see WARNINGS ) should be hospitalized when minoxidil is first administered so that they can be monitored to avoid too rapid, or large orthostatic, decreases in blood pressure.",
   "photosensitivity": false,
   "heat_kind": null,
   "names_sauna_or_hot_tub": false,
   "storage": "Store at controlled room temperature 20° to 25°C (68° to 77°F) [See USP]."
  },
  {
   "drug": "Rogaine foam",
   "generic": "minoxidil (topical)",
   "class": "Hair loss (topical)",
   "group": "Skin, hair, hormones and antibiotics",
   "label_title": "Mens rogaine Minoxidil Unscented Formula / MINOXIDIL",
   "label_type": "OTC",
   "set_id": "1b5e2860-6855-4a65-8bbc-e064172a1adf",
   "label_version": "7",
   "label_effective": "2024-11-11",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=1b5e2860-6855-4a65-8bbc-e064172a1adf",
   "guide": "https://www.tendground.com/journal/wellness-on-minoxidil-what-is-safe",
   "heat_or_thermoregulation": false,
   "decreased_sweating": false,
   "sweating": false,
   "hyperthermia": false,
   "dehydration": false,
   "orthostatic_hypotension": false,
   "photosensitivity": false,
   "heat_kind": null,
   "names_sauna_or_hot_tub": false,
   "storage": "store at controlled room temperature 20° to 25° C (68° to 77°F) contents under pressure."
  },
  {
   "drug": "AndroGel 1.62%",
   "generic": "testosterone gel",
   "class": "Testosterone",
   "group": "Skin, hair, hormones and antibiotics",
   "label_title": "AndroGel 1.62% / testosterone gel",
   "label_type": "Rx",
   "set_id": "f4e8d29b-8707-4d47-e053-2a95a90aecee",
   "label_version": "130",
   "label_effective": "2025-10-22",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=f4e8d29b-8707-4d47-e053-2a95a90aecee",
   "guide": "https://www.tendground.com/journal/wellness-on-testosterone-trt-what-is-safe",
   "heat_or_thermoregulation": false,
   "decreased_sweating": false,
   "sweating": false,
   "hyperthermia": false,
   "dehydration": false,
   "orthostatic_hypotension": false,
   "photosensitivity": false,
   "heat_kind": null,
   "names_sauna_or_hot_tub": false,
   "storage": "Store at controlled room temperature 20°-25°C (68°-77°F); excursions permitted to 15°C to 30°C (59°- 86°F) [see USP Controlled Room Temperature]."
  },
  {
   "drug": "prednisone",
   "generic": "prednisone",
   "class": "Corticosteroid",
   "group": "Skin, hair, hormones and antibiotics",
   "label_title": "Prednisone / PREDNISONE",
   "label_type": "Rx",
   "set_id": "10fe5a3b-84dc-4600-87c2-b80c97ce18cf",
   "label_version": "36",
   "label_effective": "2026-07-31",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=10fe5a3b-84dc-4600-87c2-b80c97ce18cf",
   "guide": "https://www.tendground.com/journal/wellness-on-prednisone-and-steroids-what-is-safe",
   "heat_or_thermoregulation": false,
   "decreased_sweating": false,
   "sweating": true,
   "sweating_direct": true,
   "sweating_context": "side effect",
   "sweating_section": "Adverse reactions",
   "sweating_excerpt": "…edema, atrophy and thinning of skin, dry scaly skin, ecchymoses and petechiae (bruising), erythema, facial edema, hirsutism, impaired wound healing, increased sweating, Karposi’s sarcoma (see PRECAUTIONS: General Precautions ), lupus erythematosus-like lesions, perineal irritation, purpura, rash, striae,…",
   "hyperthermia": false,
   "dehydration": false,
   "orthostatic_hypotension": false,
   "photosensitivity": false,
   "heat_kind": null,
   "names_sauna_or_hot_tub": false,
   "storage": "Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]."
  },
  {
   "drug": "Celebrex",
   "generic": "celecoxib",
   "class": "NSAID (prescription)",
   "group": "Pain relievers",
   "label_title": "CELEBREX / CELECOXIB",
   "label_type": "Rx",
   "set_id": "2d6675e4-5859-4be2-8037-a20ce9f707aa",
   "label_version": "13",
   "label_effective": "2024-11-22",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=2d6675e4-5859-4be2-8037-a20ce9f707aa",
   "guide": "https://www.tendground.com/journal/wellness-on-nsaids-ibuprofen-naproxen-what-is-safe",
   "heat_or_thermoregulation": false,
   "decreased_sweating": false,
   "sweating": true,
   "sweating_direct": true,
   "sweating_context": "side effect",
   "sweating_section": "Adverse reactions",
   "sweating_excerpt": "…Skin and appendages: Alopecia, dermatitis, photosensitivity reaction, pruritus, rash erythematous, rash maculopapular, skin disorder, skin dry, sweating increased, urticaria Application site disorders: Cellulitis, dermatitis contact Urinary: Albuminuria, cystitis, dysuria, hematuria, micturition…",
   "hyperthermia": false,
   "dehydration": true,
   "dehydration_direct": true,
   "dehydration_context": "warning",
   "dehydration_section": "Warnings and precautions",
   "dehydration_excerpt": "Renal Toxicity : Monitor renal function in patients with renal or hepatic impairment, heart failure, dehydration, or hypovolemia.",
   "orthostatic_hypotension": false,
   "photosensitivity": false,
   "heat_kind": null,
   "names_sauna_or_hot_tub": false,
   "storage": "Store at room temperature 20°C to 25°C (68°F to 77°F); excursions permitted between 15°C to 30°C (59°F to 86°F) [see USP Controlled Room Temperature]."
  },
  {
   "drug": "Motrin IB",
   "generic": "ibuprofen",
   "class": "NSAID (over the counter)",
   "group": "Pain relievers",
   "label_title": "Motrin IB / IBUPROFEN",
   "label_type": "OTC",
   "set_id": "d21129f8-4d96-4e36-bc39-a534306dd77e",
   "label_version": "15",
   "label_effective": "2025-10-03",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=d21129f8-4d96-4e36-bc39-a534306dd77e",
   "guide": "https://www.tendground.com/journal/wellness-on-nsaids-ibuprofen-naproxen-what-is-safe",
   "heat_or_thermoregulation": false,
   "decreased_sweating": false,
   "sweating": false,
   "hyperthermia": false,
   "dehydration": false,
   "orthostatic_hypotension": false,
   "photosensitivity": false,
   "heat_kind": null,
   "names_sauna_or_hot_tub": false,
   "storage": null
  },
  {
   "drug": "Aleve",
   "generic": "naproxen sodium",
   "class": "NSAID (over the counter)",
   "group": "Pain relievers",
   "label_title": "Aleve Caplets / NAPROXEN SODIUM",
   "label_type": "OTC",
   "set_id": "02941928-128a-2c88-e063-6294a90ac6ba",
   "label_version": "4",
   "label_effective": "2026-03-12",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=02941928-128a-2c88-e063-6294a90ac6ba",
   "guide": "https://www.tendground.com/journal/wellness-on-nsaids-ibuprofen-naproxen-what-is-safe",
   "heat_or_thermoregulation": false,
   "decreased_sweating": false,
   "sweating": false,
   "hyperthermia": false,
   "dehydration": false,
   "orthostatic_hypotension": false,
   "photosensitivity": false,
   "heat_kind": null,
   "names_sauna_or_hot_tub": false,
   "storage": "store at 20-25 ° C (68-77 ° F)."
  },
  {
   "drug": "fentanyl transdermal system",
   "generic": "fentanyl",
   "class": "Opioid patch",
   "group": "Skin patches",
   "label_title": "FENTANYL / FENTANYL",
   "label_type": "Rx",
   "set_id": "73897c38-e4ec-40bc-9f41-3359ee23a5a8",
   "label_version": "2",
   "label_effective": "2026-04-07",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=73897c38-e4ec-40bc-9f41-3359ee23a5a8",
   "guide": "https://www.tendground.com/journal/sauna-and-hot-tub-with-a-medicated-patch-what-is-safe",
   "heat_or_thermoregulation": true,
   "heat_or_thermoregulation_direct": true,
   "heat_or_thermoregulation_context": "warning",
   "heat_or_thermoregulation_section": "Boxed warning",
   "heat_or_thermoregulation_excerpt": "Warn patients to avoid exposing the fentanyl transdermal system application site and surrounding area to direct external heat sources.",
   "decreased_sweating": false,
   "sweating": true,
   "sweating_direct": true,
   "sweating_context": "side effect",
   "sweating_section": "Adverse reactions",
   "sweating_excerpt": "The most common adverse reactions (≥5%) in a double-blind, randomized, placebo-controlled clinical trial in patients with severe pain were nausea, vomiting, somnolence, dizziness, insomnia, constipation, hyperhidrosis, fatigue, feeling cold, and anorexia.",
   "hyperthermia": true,
   "hyperthermia_direct": true,
   "hyperthermia_context": "heat exposure or thermoregulation",
   "hyperthermia_section": "Warnings and precautions",
   "hyperthermia_excerpt": "5.9 Risk of Increased Fentanyl Absorption with Elevated Body Temperature Based on a pharmacokinetic model, serum fentanyl concentrations could theoretically increase by approximately one-third for patients with a body temperature of 40°C (104°F) due to…",
   "dehydration": false,
   "orthostatic_hypotension": true,
   "orthostatic_hypotension_direct": true,
   "orthostatic_hypotension_context": "warning",
   "orthostatic_hypotension_section": "Warnings and precautions",
   "orthostatic_hypotension_excerpt": "5.14 Severe Hypotension Fentanyl transdermal system may cause severe hypotension including orthostatic hypotension and syncope in ambulatory patients.",
   "photosensitivity": false,
   "heat_kind": "patch_heat",
   "names_sauna_or_hot_tub": true,
   "sauna_section": "Boxed warning",
   "sauna_excerpt": "…application site and surrounding area to direct external heat sources, such as heating pads or electric blankets, heat or tanning lamps, sunbathing, hot baths, saunas, hot tubs, and heated water beds may increase fentanyl absorption and has resulted in fatal overdose of fentanyl. Warn patients to avoid…",
   "storage": "Store up to 25°C (77°F); excursions permitted from 15°C to 30°C (59°F to 86°F)."
  },
  {
   "drug": "Butrans",
   "generic": "buprenorphine transdermal",
   "class": "Opioid patch",
   "group": "Skin patches",
   "label_title": "Butrans / BUPRENORPHINE",
   "label_type": "Rx",
   "set_id": "794aa355-66de-41b8-aedf-f2c40f6bc664",
   "label_version": "32",
   "label_effective": "2026-05-01",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=794aa355-66de-41b8-aedf-f2c40f6bc664",
   "guide": "https://www.tendground.com/journal/sauna-and-hot-tub-with-a-medicated-patch-what-is-safe",
   "heat_or_thermoregulation": true,
   "heat_or_thermoregulation_direct": true,
   "heat_or_thermoregulation_context": "warning",
   "heat_or_thermoregulation_section": "Warnings and precautions",
   "heat_or_thermoregulation_excerpt": "5.6 Risks of Use with Application of External Heat Advise patients and their caregivers to avoid exposing the BUTRANS application site and surrounding area to direct external heat sources, such as heating pads or electric blankets, heat or tanning…",
   "decreased_sweating": false,
   "sweating": true,
   "sweating_direct": true,
   "sweating_context": "side effect",
   "sweating_section": "Adverse reactions",
   "sweating_excerpt": "…9% Somnolence 13% 4% Constipation 13% 5% Vomiting 9% 1% Application site erythema 7% 2% Application site rash 6% 6% Dry mouth 6% 2% Fatigue 5% 1% Hyperhidrosis 4% 1% Peripheral edema 3% 1% Pruritus 3% 0% Stomach discomfort 2% 0% The adverse reactions seen in controlled and open-label studies are presented…",
   "hyperthermia": false,
   "dehydration": true,
   "dehydration_direct": true,
   "dehydration_context": "side effect",
   "dehydration_section": "Adverse reactions",
   "dehydration_excerpt": "The most common serious adverse drug reactions (all <0.1%) occurring during clinical trials with BUTRANS were: chest pain, abdominal pain, vomiting, dehydration, and hypertension/blood pressure increased.",
   "orthostatic_hypotension": true,
   "orthostatic_hypotension_direct": true,
   "orthostatic_hypotension_context": "warning",
   "orthostatic_hypotension_section": "Warnings and precautions",
   "orthostatic_hypotension_excerpt": "5.12 Severe Hypotension BUTRANS may cause severe hypotension including orthostatic hypotension and syncope in ambulatory patients.",
   "photosensitivity": false,
   "heat_kind": "patch_heat",
   "names_sauna_or_hot_tub": true,
   "sauna_section": "Warnings and precautions",
   "sauna_excerpt": "…the BUTRANS application site and surrounding area to direct external heat sources, such as heating pads or electric blankets, heat or tanning lamps, saunas, hot tubs, and heated water beds while wearing the system because an increase in absorption of buprenorphine may occur [see Clinical Pharmacology…",
   "storage": "Store at 25°C (77°F); excursions permitted between 15°C - 30°C (59°F - 86°F)."
  },
  {
   "drug": "NicoDerm CQ",
   "generic": "nicotine transdermal",
   "class": "Nicotine patch",
   "group": "Skin patches",
   "label_title": "NICODERM CQ / NICOTINE",
   "label_type": "OTC",
   "set_id": "93b2d1b9-83c1-40b5-b6af-90c38c8d6cef",
   "label_version": "14",
   "label_effective": "2025-07-14",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=93b2d1b9-83c1-40b5-b6af-90c38c8d6cef",
   "guide": "https://www.tendground.com/journal/sauna-and-hot-tub-with-a-medicated-patch-what-is-safe",
   "heat_or_thermoregulation": false,
   "decreased_sweating": false,
   "sweating": false,
   "hyperthermia": false,
   "dehydration": false,
   "orthostatic_hypotension": false,
   "photosensitivity": false,
   "heat_kind": null,
   "names_sauna_or_hot_tub": false,
   "storage": "store at 20-25°C (68-77°F)  Additional Information ( Step 1 ) Read carton and enclosed User’s Guide before using this product."
  },
  {
   "drug": "Climara Pro",
   "generic": "estradiol and levonorgestrel transdermal",
   "class": "Hormone patch (HRT)",
   "group": "Skin patches",
   "label_title": "Climara Pro / ESTRADIOL AND LEVONORGESTREL",
   "label_type": "Rx",
   "set_id": "184d3092-7fc6-4375-816b-1ab06bb99cfd",
   "label_version": "27",
   "label_effective": "2026-03-26",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=184d3092-7fc6-4375-816b-1ab06bb99cfd",
   "guide": "https://www.tendground.com/journal/sauna-and-hot-tub-with-a-medicated-patch-what-is-safe",
   "heat_or_thermoregulation": true,
   "heat_or_thermoregulation_direct": true,
   "heat_or_thermoregulation_context": "directions for use",
   "heat_or_thermoregulation_section": "Dosage and administration",
   "heat_or_thermoregulation_excerpt": "Swimming, bathing, or using a sauna while using Climara Pro has not been studied, and these activities may decrease the adhesion of the system and the delivery of the estrogen and progestin.",
   "decreased_sweating": false,
   "sweating": false,
   "hyperthermia": false,
   "dehydration": false,
   "orthostatic_hypotension": false,
   "photosensitivity": false,
   "heat_kind": "drug_or_device",
   "names_sauna_or_hot_tub": true,
   "sauna_section": "Dosage and administration",
   "sauna_excerpt": "Swimming, bathing, or using a sauna while using Climara Pro has not been studied, and these activities may decrease the adhesion of the system and the delivery of the estrogen and progestin.",
   "storage": "Store at 20°C to 25°C (68°F to 77°F); excursions permitted to 15°C to 30°C (59°F to 86°F) [see USP controlled Room Temperature]."
  },
  {
   "drug": "Xulane",
   "generic": "norelgestromin and ethinyl estradiol transdermal",
   "class": "Contraceptive patch",
   "group": "Skin patches",
   "label_title": "XULANE / NORELGESTROMIN AND ETHINYL ESTRADIOL",
   "label_type": "Rx",
   "set_id": "f7848550-086a-43d8-8ae5-047f4b9e4382",
   "label_version": "17",
   "label_effective": "2022-03-04",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=f7848550-086a-43d8-8ae5-047f4b9e4382",
   "guide": "https://www.tendground.com/journal/sauna-and-hot-tub-with-a-medicated-patch-what-is-safe",
   "heat_or_thermoregulation": true,
   "heat_or_thermoregulation_direct": true,
   "heat_or_thermoregulation_context": "pharmacology",
   "heat_or_thermoregulation_section": "Clinical pharmacology",
   "heat_or_thermoregulation_excerpt": "The absorption of NGMN and EE following application of norelgestromin and ethinyl estradiol transdermal system was studied under conditions encountered in a health club (sauna, whirlpool and treadmill) and in a cold water bath. The results indicated that for NGMN, there were no significant treatment effects on C ss or AUC when compared to normal wear. For EE, increased exposures were observed due to sauna, whirlpool and treadmill.",
   "decreased_sweating": false,
   "sweating": false,
   "hyperthermia": false,
   "dehydration": false,
   "orthostatic_hypotension": false,
   "photosensitivity": true,
   "photosensitivity_direct": true,
   "photosensitivity_context": "warning",
   "photosensitivity_section": "Warnings and precautions",
   "photosensitivity_excerpt": "Women with a tendency to chloasma should avoid exposure to the sun or ultraviolet radiation while using Xulane.",
   "heat_kind": "drug_or_device",
   "names_sauna_or_hot_tub": true,
   "sauna_section": "Clinical pharmacology",
   "sauna_excerpt": "…time of patch removal.) The absorption of NGMN and EE following application of norelgestromin and ethinyl estradiol transdermal system was studied under conditions encountered in a health club (sauna, whirlpool and treadmill) and in a cold water bath.",
   "storage": "Store at 20° to 25°C (68° to 77°F)."
  },
  {
   "drug": "Transderm Scop",
   "generic": "scopolamine transdermal",
   "class": "Anticholinergic patch (motion sickness)",
   "group": "Skin patches",
   "label_title": "Transderm Scop / SCOPOLAMINE",
   "label_type": "Rx",
   "set_id": "b877a694-a1d0-4280-937a-a06820b12a88",
   "label_version": "20",
   "label_effective": "2025-06-10",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=b877a694-a1d0-4280-937a-a06820b12a88",
   "guide": null,
   "heat_or_thermoregulation": true,
   "heat_or_thermoregulation_direct": true,
   "heat_or_thermoregulation_context": "warning",
   "heat_or_thermoregulation_section": "Warnings and precautions",
   "heat_or_thermoregulation_excerpt": "Anticholinergic agents, including scopolamine, can increase core body temperature and reduce sweating, which may cause further increases in body temperature.",
   "decreased_sweating": true,
   "decreased_sweating_direct": true,
   "decreased_sweating_context": "warning",
   "decreased_sweating_section": "Warnings and precautions",
   "decreased_sweating_excerpt": "Anticholinergic agents, including scopolamine, can increase core body temperature and reduce sweating, which may cause further increases in body temperature.",
   "sweating": true,
   "sweating_direct": false,
   "sweating_context": "withdrawal",
   "sweating_section": "Warnings and precautions",
   "sweating_excerpt": "5.6 Drug Withdrawal/Post-Removal Symptoms Discontinuation of TRANSDERM SCŌP, usually after several days of use, may result in withdrawal symptoms, such as disturbances of equilibrium, dizziness, nausea, vomiting, abdominal cramps, sweating, headache, mental confusion, muscle weakness, bradycardia and hypotension.",
   "hyperthermia": true,
   "hyperthermia_direct": true,
   "hyperthermia_context": "heat exposure or thermoregulation",
   "hyperthermia_section": "Warnings and precautions",
   "hyperthermia_excerpt": "Hyperthermia may be exacerbated by exposure to external heat sources or high environmental temperature.",
   "dehydration": false,
   "orthostatic_hypotension": false,
   "photosensitivity": false,
   "heat_kind": "less_sweating",
   "names_sauna_or_hot_tub": false,
   "storage": "Store at controlled room temperature between 20°C to 25°C (68°F to 77°F)."
  },
  {
   "drug": "dronabinol",
   "generic": "dronabinol",
   "class": "Cannabinoid (prescription)",
   "group": "Other",
   "label_title": "Dronabinol / DRONABINOL",
   "label_type": "Rx",
   "set_id": "adb1801c-0fb5-4e16-b969-1db91230e0b9",
   "label_version": "5",
   "label_effective": "2026-05-06",
   "dailymed_url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=adb1801c-0fb5-4e16-b969-1db91230e0b9",
   "guide": "https://www.tendground.com/journal/sauna-and-cannabis-what-is-safe",
   "heat_or_thermoregulation": false,
   "decreased_sweating": false,
   "sweating": true,
   "sweating_direct": true,
   "sweating_context": "side effect",
   "sweating_section": "Adverse reactions",
   "sweating_excerpt": "…Myalgias Central Nervous System Depression, nightmares, speech difficulties, tinnitus Respiratory Cough, rhinitis, sinusitis Skin Flushing, sweating Sensory Vision difficulties 6.2 Postmarketing Experience The following adverse reactions have been identified during post-approval use of dronabinol…",
   "hyperthermia": false,
   "dehydration": true,
   "dehydration_direct": true,
   "dehydration_context": "warning",
   "dehydration_section": "Warnings and precautions",
   "dehydration_excerpt": "In some cases, these adverse reactions were severe (e.g., dehydration, electrolyte abnormalities) and required dose reduction or drug discontinuation.",
   "orthostatic_hypotension": true,
   "orthostatic_hypotension_direct": true,
   "orthostatic_hypotension_context": "pharmacology",
   "orthostatic_hypotension_section": "Clinical pharmacology",
   "orthostatic_hypotension_excerpt": "Its effects on blood pressure are inconsistent, but subjects have experienced orthostatic hypotension and/or syncope upon abrupt standing [see Warnings and Precautions ( 5.2 )].",
   "photosensitivity": false,
   "heat_kind": null,
   "names_sauna_or_hot_tub": false,
   "storage": "stored in a cool environment between 8° and 15°C (46° and 59°F) and alternatively could be stored in a refrigerator."
  }
 ]
}