Original data · labels checked October 4, 2026

What 83 FDA drug labels say about heat, sweating and the sun

Name: Tendground medication heat-warning label index
Creator: Tendground
Published: 2026-10-04
License: https://creativecommons.org/licenses/by/4.0/

We read the official FDA labels of 83 common medications and recorded, word for word, where each one mentions heat, reduced sweating, overheating, dehydration, dizziness on standing or sun sensitivity. 24 use heat language. Only 4 name saunas or hot tubs, and all 4 are skin patches. The data is free to cite and to download as CSV or JSON (CC BY 4.0).

Labels with heat language

Warn of reduced sweating

Name saunas or hot tubs

Mention sun sensitivity

What the labels say

24 of 83 labels use heat language, and it clusters: drugs that reduce sweating, antipsychotics, skin patches, and a few labels that name hot weather.
9 say the drug can reduce sweating, and all of them tie it to overheating or heat stroke.
Only 4 name saunas, hot tubs or hot baths, all of them skin patches. No pill or capsule label in the index names a sauna.
31 mention hyperthermia or heat stroke, but only 19 do so directly. The rest mention it only as a symptom of a rare reaction such as serotonin syndrome, or in the overdose section.
50 mention sweating; 34 list it as a side effect of the drug itself.
33 mention dizziness or a blood pressure drop on standing, 28 mention dehydration, and 27 mention sun sensitivity.
15 labels use none of the seven terms, including all 8 over-the-counter labels, which are short. A blank is not a safety claim.

Each statement below is quoted from the label with its section, and each label links to its page on DailyMed, the National Library of Medicine's official source of FDA label information. 54 of the 83 labels were updated in the past year; the oldest is from Mar 4, 2022.

Heat warnings by kind

We grouped the 24 labels with heat language by what the heat statement is about. The grouping is ours; each quote is the label's.

Keep heat off the patch · 3

Daytrana, fentanyl transdermal system, Butrans

"( 5.10 ) External Heat: Patients should be advised to avoid exposing the DAYTRANA application site to direct external heat sources." Daytrana, Warnings and precautions

Less sweating, more risk of overheating · 9

Topamax, Qsymia, Zonisade, oxybutynin, benztropine, glycopyrrolate (oral), hyoscyamine, solifenacin (Vesicare), Transderm Scop

"Patients (especially pediatric patients) treated with TOPAMAX should be monitored closely for evidence of decreased sweating and increased body temperature, especially in hot weather." Topamax, Warnings and precautions

Body temperature regulation · 5

Abilify, Risperdal, Zyprexa, Seroquel, Seroquel XR

"5.13 Body Temperature Regulation Disruption of the body's ability to reduce core body temperature has been attributed to antipsychotic agents." Abilify, Warnings and precautions

Hot weather named as a risk · 3

amitriptyline, lithium carbonate, hydrochlorothiazide

"Hyperpyrexia has been reported when amitriptyline is administered with anticholinergic agents or with neuroleptic drugs, particularly during hot weather." amitriptyline, Precautions

Heat or a sauna affects the drug or how it is delivered · 3

Humalog, Climara Pro, Xulane

"Instruct patients to discard insulin exposed to temperatures higher than 98.6°F (37°C). The temperature of the insulin may exceed ambient temperature when the pump housing, cover, tubing or sport case is exposed to sunlight or radiant heat." Humalog, Patient counseling

Heat intolerance as a sign of too much thyroid hormone · 1

Synthroid

"Adverse reactions associated with SYNTHROID therapy are primarily those of hyperthyroidism due to therapeutic overdosage … General: fatigue, increased appetite, weight loss, heat intolerance, fever, excessive sweating" Synthroid, Adverse reactions

All 83 labels at a glance

● the label states it directly: a warning, a listed side effect, advice to patients, or a statement tied to heat. ○ mentioned only as a symptom of a rare reaction, of overdose, of stopping the drug, or with certain other drugs. A blank means none of the terms appear in the label version we checked. Tap a medicine for the quotes.

Medicine	Heat or temperature regulation	Reduced sweating	Overheating or heat stroke	Sweating	Dehydration	Dizziness on standing	Sun sensitivity
ADHD stimulants	Heat	Less sweat	Overheating	Sweating	Dehydration	Dizzy on standing	Sun
Adderall			○	○
Adderall XR			○	●			●
Vyvanse			○	●
Ritalin			●	●
Concerta			●	●
Daytrana	●		○	○
Antidepressants and lithium	Heat	Less sweat	Overheating	Sweating	Dehydration	Dizzy on standing	Sun
Zoloft			○	●			●
Lexapro			○	●		●	●
Prozac			○	●			●
Effexor XR			○	●		●	●
Cymbalta			○	●	●	●	●
Wellbutrin XL				●		●	●
amitriptyline	○		●	●		●	●
lithium carbonate	●		○	●	●
Antipsychotics	Heat	Less sweat	Overheating	Sweating	Dehydration	Dizzy on standing	Sun
Abilify	●		●	●	●	●	●
Risperdal	●		●	○	●	●
Zyprexa	●		○	●	●	●	●
Seroquel	●		●	●	●	●
Seroquel XR	●		●	●	●	●
haloperidol			●	●	●	●	●
Clozaril			●	●	●	●	●
Anticonvulsants	Heat	Less sweat	Overheating	Sweating	Dehydration	Dizzy on standing	Sun
Topamax	●	●	●			●
Qsymia	●	●	●
Zonisade	●	●	●	●	●
Lamictal				●		●	●
Neurontin				○
Sleep and anxiety	Heat	Less sweat	Overheating	Sweating	Dehydration	Dizzy on standing	Sun
trazodone			○	○		●
Xanax				○			●
Ambien				●		●	●
Anticholinergics and antihistamines	Heat	Less sweat	Overheating	Sweating	Dehydration	Dizzy on standing	Sun
oxybutynin	●	●	●		○
benztropine	●	●	●
glycopyrrolate (oral)	●	●	●
hyoscyamine	●	●	●
tolterodine (Detrol)
solifenacin (Vesicare)	●	●	●
Benadryl
Unisom SleepTabs
hydroxyzine
Zyrtec
Allegra-D
Blood pressure and heart	Heat	Less sweat	Overheating	Sweating	Dehydration	Dizzy on standing	Sun
Norvasc				●
Zestril				●	●	●	●
Cozaar					●	●	●
Toprol-XL				●		○	●
propranolol						●
hydrochlorothiazide	●				○	●	●
Lasix				○	●	●	●
Aldactone					●
clonidine (Catapres)						●
Viagra				●	●	●	●
Cialis				●	●	●
Lipitor
Blood thinners	Heat	Less sweat	Overheating	Sweating	Dehydration	Dizzy on standing	Sun
Eliquis
Xarelto
warfarin
Diabetes and weight	Heat	Less sweat	Overheating	Sweating	Dehydration	Dizzy on standing	Sun
metformin				●	●
Jardiance				○	●	●
Farxiga				○	●	●
Ozempic				○	●
Wegovy				○	●	●
Mounjaro				○	●
Zepbound				○	●	●
Humalog	●			●
Synthroid	○			○
Skin, hair, hormones and antibiotics	Heat	Less sweat	Overheating	Sweating	Dehydration	Dizzy on standing	Sun
Claravis				●			●
Retin-A Micro							●
Tazorac							●
Doryx MPC							●
ciprofloxacin				●			●
minoxidil tablets						●
Rogaine foam
AndroGel 1.62%
prednisone				●
Pain relievers	Heat	Less sweat	Overheating	Sweating	Dehydration	Dizzy on standing	Sun
Celebrex				●	●
Motrin IB
Aleve
Skin patches	Heat	Less sweat	Overheating	Sweating	Dehydration	Dizzy on standing	Sun
fentanyl transdermal system	●		●	●		●
Butrans	●			●	●	●
NicoDerm CQ
Climara Pro	●
Xulane	●						●
Transderm Scop	●	●	●	○
Other	Heat	Less sweat	Overheating	Sweating	Dehydration	Dizzy on standing	Sun
dronabinol				●	●	●

What each label says, word for word

One entry per medicine: the label we read, then the strongest statement in each category, quoted with its section. "…" marks text we left out.

ADHD stimulants

Adderall · amphetamine and dextroamphetamine · Stimulant (ADHD)

Label: Adderall / DEXTROAMPHETAMINE SACCHARATE, AMPHETAMINE ASPARTATE, DEXTROAMPHETAMINE SULFATE, AND AMPHETAMINE SULFATE (prescription), effective May 29, 2024. Open on DailyMed · Our guide

Overheating or heat stroke · Only as a symptom of serotonin syndrome, a rare reaction · Warnings: "…agitation, hallucinations, delirium, and coma), autonomic instability (e.g., tachycardia, labile blood pressure, dizziness, diaphoresis, flushing, hyperthermia), neuromuscular symptoms (e.g., tremor, rigidity, myoclonus, hyperreflexia, incoordination), seizures, and/or gastrointestinal symptoms (e.g.,…"
Sweating · Only as a symptom of serotonin syndrome, a rare reaction · Warnings: "…status changes (e.g., agitation, hallucinations, delirium, and coma), autonomic instability (e.g., tachycardia, labile blood pressure, dizziness, diaphoresis, flushing, hyperthermia), neuromuscular symptoms (e.g., tremor, rigidity, myoclonus, hyperreflexia, incoordination), seizures, and/or…"

Adderall XR · amphetamine and dextroamphetamine, extended release · Stimulant (ADHD)

Label: Adderall XR / DEXTROAMPHETAMINE SULFATE, DEXTROAMPHETAMINE SACCHARATE, AMPHETAMINE SULFATE AND AMPHETAMINE ASPARTATE (prescription), effective Apr 30, 2026. Open on DailyMed · Our guide

Overheating or heat stroke · Only as a symptom of serotonin syndrome, a rare reaction · Warnings and precautions: "…agitation, hallucinations, delirium, and coma), autonomic instability (e.g., tachycardia, labile blood pressure, dizziness, diaphoresis, flushing, hyperthermia), neuromuscular symptoms (e.g., tremor, rigidity, myoclonus, hyperreflexia, incoordination), seizures, and/or gastrointestinal symptoms (e.g.,…"
Sweating · Side effect · Adverse reactions: "…tooth disorder (e.g., teeth clenching, tooth infection), emotional lability, libido decreased, somnolence, speech disorder (e.g., stuttering, excessive speech), palpitation, twitching, dyspnea, sweating, dysmenorrhea, and impotence."
Sun sensitivity · Side effect · Adverse reactions: "…were reported by 2 to 4% of adult patients receiving ADDERALL XR with a higher incidence than patients receiving placebo in this study: infection, photosensitivity reaction, constipation, tooth disorder (e.g., teeth clenching, tooth infection), emotional lability, libido decreased, somnolence, speech disorder…"

Vyvanse · lisdexamfetamine · Stimulant (ADHD)

Label: Vyvanse / LISDEXAMFETAMINE DIMESYLATE (prescription), effective Apr 30, 2026. Open on DailyMed · Our guide

Overheating or heat stroke · Only as a symptom of serotonin syndrome, a rare reaction · Warnings and precautions: "…agitation, hallucinations, delirium, and coma), autonomic instability (e.g., tachycardia, labile blood pressure, dizziness, diaphoresis, flushing, hyperthermia), neuromuscular symptoms (e.g., tremor, rigidity, myoclonus, hyperreflexia, incoordination), seizures, and/or gastrointestinal symptoms (e.g.,…"
Sweating · Side effect · Adverse reactions: "…8% Dry Mouth 26% 3% Diarrhea 7% 0% Nausea 7% 0% Anxiety 6% 0% Anorexia 5% 0% Feeling Jittery 4% 0% Agitation 3% 0% Increased Blood Pressure 3% 0% Hyperhidrosis 3% 0% Restlessness 3% 0% Decreased Weight 3% 0% Dyspnea 2% 0% Increased Heart Rate 2% 0% Tremor 2% 0% Palpitations 2% 0% In addition, in the adult…"

Ritalin · methylphenidate · Stimulant (ADHD)

Label: Ritalin / methylphenidate (prescription), effective Feb 5, 2025. Open on DailyMed · Our guide

Overheating or heat stroke · Side effect · Adverse reactions: "…myalgia, muscle twitching Renal and Urinary Disorders: hematuria Reproductive System and Breast Disorders: gynecomastia General Disorders: fatigue, hyperpyrexia Urogenital Disorders: priapism Common adverse reactions: tachycardia, palpitations, headache, insomnia, anxiety, hyperhidrosis, weight loss,…"
Sweating · Side effect · Adverse reactions: "…Disorders: abnormal liver function, ranging from transaminase elevation to severe hepatic injury Skin and Subcutaneous Tissue Disorders: hyperhidrosis, pruritus, urticaria, exfoliative dermatitis, scalp hair loss, erythema multiforme rash, thrombocytopenic purpura Musculoskeletal and Connective…"

Concerta · methylphenidate, extended release · Stimulant (ADHD)

Label: CONCERTA / METHYLPHENIDATE HYDROCHLORIDE (prescription), effective Apr 20, 2026. Open on DailyMed · Our guide

Overheating or heat stroke · Side effect · Adverse reactions: "…: Diplopia, Increased intraocular pressure, Mydriasis General Disorders and Administration Site Conditions : Chest pain, Drug effect decreased, Hyperpyrexia Hepatobiliary Disorders : Hepatocellular injury, Acute hepatic failure, Blood bilirubin increased Immune System Disorders : Hypersensitivity…"
Sweating · Side effect · Adverse reactions: "( 6.1 ) Adults up to 65 years of age: decreased appetite, headache, dry mouth, nausea, insomnia, anxiety, dizziness, weight decreased, irritability, tachycardia, and hyperhidrosis."

Daytrana · methylphenidate transdermal patch · Stimulant (ADHD), patch

Label: Daytrana / METHYLPHENIDATE (prescription), effective Sep 1, 2025. Open on DailyMed · Our guide

Heat or temperature regulation · Warning · Warnings and precautions: "( 5.10 ) External Heat: Patients should be advised to avoid exposing the DAYTRANA application site to direct external heat sources."
Overheating or heat stroke · Only in the overdose section · Overdosage: "Life-threatening hyperthermia (temperatures greater than 104°F) and rhabdomyolysis may develop."
Sweating · Only with misuse · Drug abuse and dependence: "Misuse and abuse of methylphenidate may cause increased heart rate, respiratory rate, or blood pressure; sweating; dilated pupils; hyperactivity; restlessness; insomnia; decreased appetite; loss of coordination; tremors; flushed skin; vomiting; and/or abdominal pain."

Antidepressants and lithium

Zoloft · sertraline · Antidepressant (SSRI)

Label: Zoloft / SERTRALINE HYDROCHLORIDE (prescription), effective Aug 8, 2023. Open on DailyMed · Our guide

Overheating or heat stroke · Only as a symptom of serotonin syndrome, a rare reaction · Warnings and precautions: "…agitation, hallucinations, delirium, and coma), autonomic instability (e.g., tachycardia, labile blood pressure, dizziness, diaphoresis, flushing, hyperthermia), neuromuscular symptoms (e.g., tremor, rigidity, myoclonus, hyperreflexia, incoordination), seizures, and gastrointestinal symptoms (e.g., nausea,…"
Sweating · Side effect · Adverse reactions: "…adverse reactions (≥5% and twice placebo) in pooled placebo-controlled MDD, OCD, PD, PTSD, SAD and PMDD clinical trials were nausea, diarrhea/loose stool, tremor, dyspepsia, decreased appetite, hyperhidrosis, ejaculation failure, and decreased libido."
Sun sensitivity · Side effect · Adverse reactions: "…thoracic and mediastinal disorders - pulmonary hypertension, eosinophilic pneumonia, anosmia, hyposmia Skin and subcutaneous tissue disorders - photosensitivity skin reaction and other severe cutaneous reactions, which potentially can be fatal, such as Stevens-Johnson Syndrome (SJS) and toxic epidermal…"

Lexapro · escitalopram · Antidepressant (SSRI)

Label: Lexapro / escitalopram (prescription), effective Jan 15, 2024. Open on DailyMed · Our guide

Overheating or heat stroke · Only as a symptom of serotonin syndrome, a rare reaction · Warnings and precautions: "…agitation, hallucinations, delirium, and coma), autonomic instability (e.g., tachycardia, labile blood pressure, dizziness, diaphoresis, flushing, hyperthermia), neuromuscular symptoms (e.g., tremor, rigidity, myoclonus, hyperreflexia, incoordination) seizures, and/or gastrointestinal symptoms (e.g.,…"
Sweating · Side effect · Adverse reactions: "6 ADVERSE REACTIONS Most commonly observed adverse reactions (incidence ≥ 5% and at least twice the incidence of placebo patients) are: insomnia, ejaculation disorder (primarily ejaculatory delay), nausea, sweating increased, fatigue and somnolence, decreased libido, and anorgasmia ( 6.1 )."
Dizziness on standing · Side effect · Adverse reactions: "Vascular Disorders: deep vein thrombosis, flushing, hypertensive crisis, hypotension, orthostatic hypotension, phlebitis, thrombosis."
Sun sensitivity · Side effect · Adverse reactions: "Skin and Subcutaneous Tissue Disorders: alopecia, angioedema, dermatitis, ecchymosis, erythema multiforme, photosensitivity reaction, Stevens Johnson Syndrome, toxic epidermal necrolysis, urticaria."

Prozac · fluoxetine · Antidepressant (SSRI)

Label: Prozac / FLUOXETINE HYDROCHLORIDE (prescription), effective Jan 8, 2026. Open on DailyMed · Our guide

Overheating or heat stroke · Only as a symptom of serotonin syndrome, a rare reaction · Warnings and precautions: "…agitation, hallucinations, delirium, and coma), autonomic instability (e.g., tachycardia, labile blood pressure, dizziness, diaphoresis, flushing, hyperthermia), neuromuscular symptoms (e.g., tremor, rigidity, myoclonus, hyperreflexia, incoordination), seizures, and/or gastrointestinal symptoms (e.g.,…"
Sweating · Side effect · Adverse reactions: "…diarrhea, dry mouth, dyspepsia, flu syndrome, impotence, insomnia, libido decreased, nausea, nervousness, pharyngitis, rash, sinusitis, somnolence, sweating, tremor, vasodilatation, and yawn ( 6.1 ) PROZAC and olanzapine in combination – Also refer to the Adverse Reactions section of the package insert…"
Sun sensitivity · Side effect · Adverse reactions: "Body as a Whole — Frequent: chills; Infrequent: suicide attempt; Rare: acute abdominal syndrome, photosensitivity reaction."

Effexor XR · venlafaxine · Antidepressant (SNRI)

Label: Effexor XR / VENLAFAXINE HYDROCHLORIDE (prescription), effective Aug 15, 2023. Open on DailyMed · Our guide

Overheating or heat stroke · Only as a symptom of serotonin syndrome, a rare reaction · Warnings and precautions: "…agitation, hallucinations, delirium, coma), autonomic instability (e.g., tachycardia, labile blood pressure, dizziness, diaphoresis, flushing, hyperthermia), neuromuscular symptoms (e.g., tremor, rigidity, myoclonus, hyperreflexia, incoordination), seizures, and gastrointestinal symptoms (e.g., nausea,…"
Sweating · Side effect · Adverse reactions: "Sexual Dysfunction [see Warnings and Precautions (5.13) ] Most common adverse reactions (incidence ≥5% and at least twice the rate of placebo): nausea, somnolence, dry mouth, sweating, abnormal ejaculation, anorexia, constipation, impotence (men), and libido decreased ( 6.1 )."
Dizziness on standing · Side effect · Adverse reactions: "…(men) 5.3 1.0 Other Adverse Reactions Observed in Clinical Studies Body as a Whole – Photosensitivity reaction, chills Cardiovascular System – Postural hypotension, syncope, hypotension, tachycardia Digestive System – Gastrointestinal hemorrhage [see Warnings and Precautions (5.4) ] , bruxism Hemic/Lymphatic…"
Sun sensitivity · Side effect · Adverse reactions: "…(Effexor XR, n = 2,118; placebo, n = 1,274) 2.0 0.2 Impotence (men) 5.3 1.0 Other Adverse Reactions Observed in Clinical Studies Body as a Whole – Photosensitivity reaction, chills Cardiovascular System – Postural hypotension, syncope, hypotension, tachycardia Digestive System – Gastrointestinal hemorrhage [see…"

Cymbalta · duloxetine · Antidepressant (SNRI)

Label: Cymbalta / duloxetine (prescription), effective Jul 21, 2025. Open on DailyMed

Overheating or heat stroke · Only as a symptom of serotonin syndrome, a rare reaction · Warnings and precautions: "…agitation, hallucinations, delirium, and coma), autonomic instability (e.g., tachycardia, labile blood pressure, dizziness, diaphoresis, flushing, hyperthermia), neuromuscular symptoms (e.g., tremor, rigidity, myoclonus, hyperreflexia, incoordination), seizures, and gastrointestinal symptoms (e.g., nausea,…"
Sweating · Side effect · Adverse reactions: "…and at least twice the incidence of placebo-treated patients): ( 6.1 ) Adults : nausea, dry mouth, somnolence, constipation, decreased appetite, and hyperhidrosis Pediatric Patients : decreased weight, decreased appetite, nausea, vomiting, fatigue, and diarrhea To report SUSPECTED ADVERSE REACTIONS, contact…"
Dehydration · Side effect · Adverse reactions: "Metabolism and Nutrition Disorders — Infrequent: dehydration and hyperlipidemia; Rare: dyslipidemia."
Dizziness on standing · Warning · Warnings and precautions: "5.3 Orthostatic Hypotension, Falls and Syncope Orthostatic hypotension, falls, and syncope have been reported in patients treated with the recommended CYMBALTA dosages."
Sun sensitivity · Side effect · Adverse reactions: "Skin and Subcutaneous Tissue Disorders — Frequent: pruritus; Infrequent: cold sweat, dermatitis contact, erythema, increased tendency to bruise, night sweats, and photosensitivity reaction; Rare: ecchymosis."

Wellbutrin XL · bupropion · Antidepressant

Label: WELLBUTRIN XL / BUPROPION HYDROCHLORIDE (prescription), effective Feb 10, 2026. Open on DailyMed · Our guide

Sweating · Side effect · Adverse reactions: "…are (incidence ≥5%; ≥2× placebo rate): dry mouth, nausea, insomnia, dizziness, pharyngitis, abdominal pain, agitation, anxiety, tremor, palpitation, sweating, tinnitus, myalgia, anorexia, urinary frequency, rash. ( 6.1 ) To report SUSPECTED ADVERSE REACTIONS, contact Bausch Health US, LLC at…"
Dizziness on standing · Side effect · Adverse reactions: "Cardiovascular Postural hypotension, hypertension, stroke, vasodilation, syncope, complete atrioventricular block, extrasystoles, myocardial infarction, phlebitis, pulmonary embolism, and Brugada pattern/syndrome."
Sun sensitivity · Side effect · Adverse reactions: "Body (General) Chills, facial edema, edema, peripheral edema, musculoskeletal chest pain, photosensitivity, and malaise."

amitriptyline · amitriptyline · Antidepressant (tricyclic)

Label: Amitriptyline Hydrochloride / AMITRIPTYLINE HYDROCHLORIDE (prescription), effective Sep 8, 2026. Open on DailyMed · Our guide

Heat or temperature regulation · Only with certain other drugs · Precautions: "Hyperpyrexia has been reported when amitriptyline is administered with anticholinergic agents or with neuroleptic drugs, particularly during hot weather."
Overheating or heat stroke · Side effect · Adverse reactions: "Anticholinergic: Paralytic ileus; hyperpyrexia; urinary retention; dilatation of the urinary tract; constipation; blurred vision, disturbance of accommodation, increased ocular pressure, mydriasis; dry mouth."
Sweating · Side effect · Adverse reactions: "Other: Alopecia; edema; weight gain or loss; urinary frequency; increased perspiration; hyponatremia."
Dizziness on standing · Side effect · Adverse reactions: "Cardiovascular: Myocardial infarction; stroke; nonspecific ECG changes and changes in AV conduction; heart block; arrhythmias; hypotension, particularly orthostatic hypotension; syncope; hypertension; tachycardia; palpitation."
Sun sensitivity · Side effect · Adverse reactions: "Allergic: Skin rash; urticaria; photosensitization; edema of face and tongue."

lithium carbonate · lithium · Mood stabilizer

Label: Lithium Carbonate / LITHIUM CARBONATE (prescription), effective Oct 2, 2023. Open on DailyMed · Our guide

Heat or temperature regulation · Advice to patients · Medication Guide: "Avoid becoming overheated or dehydrated during exercise and in hot weather."
Overheating or heat stroke · Only as a symptom of serotonin syndrome, a rare reaction · Warnings and precautions: "…agitation, hallucinations, delirium, and coma), autonomic instability (e.g., tachycardia, labile blood pressure, dizziness, diaphoresis, flushing, hyperthermia), neuromuscular symptoms (e.g., tremor, rigidity, myoclonus, hyperreflexia, incoordination), seizures, and gastrointestinal symptoms (e.g., nausea,…"
Sweating · Warning · Warnings and precautions: "Dehydration from protracted sweating, diarrhea, or elevated temperatures from infection increases risk of hyponatremia and lithium toxicity."
Dehydration · Warning · Warnings and precautions: "Dehydration from protracted sweating, diarrhea, or elevated temperatures from infection increases risk of hyponatremia and lithium toxicity."

Antipsychotics

Abilify · aripiprazole · Antipsychotic

Label: ABILIFY / ARIPIPRAZOLE (prescription), effective Jan 29, 2025. Open on DailyMed · Our guide

Heat or temperature regulation · Warning · Warnings and precautions: "5.13 Body Temperature Regulation Disruption of the body's ability to reduce core body temperature has been attributed to antipsychotic agents."
Overheating or heat stroke · Side effect · Adverse reactions: "…– hepatitis, jaundice Immune System Disorders: rare – hypersensitivity Injury, Poisoning, and Procedural Complications: infrequent – fall; rare – heat stroke Investigations: frequent – blood prolactin decreased, weight decreased, infrequent – hepatic enzyme increased, blood glucose increased, blood…"
Sweating · Side effect · Adverse reactions: "…Respiratory, Thoracic, and Mediastinal Disorders: infrequent – nasal congestion, dyspnea Skin and Subcutaneous Tissue Disorders: infrequent – rash, hyperhidrosis, pruritus, photosensitivity reaction, alopecia; rare – urticaria Vascular Disorders: infrequent – hypotension, hypertension Pediatric Patients Most…"
Dehydration · Warning · Warnings and precautions: "…) Orthostatic Hypotension: Monitor heart rate and blood pressure and warn patients with known cardiovascular or cerebrovascular disease, and risk of dehydration or syncope ( 5.8 ) Leukopenia, Neutropenia, and Agranulocytosis: have been reported with antipsychotics including ABILIFY. Patients with a history…"
Dizziness on standing · Warning · Warnings and precautions: "…antipsychotic use. Monitor weight ( 5.6 ) Pathological Gambling and Other Compulsive Behaviors: Consider dose reduction or discontinuation ( 5.7 ) Orthostatic Hypotension: Monitor heart rate and blood pressure and warn patients with known cardiovascular or cerebrovascular disease, and risk of dehydration or syncope (…"
Sun sensitivity · Side effect · Adverse reactions: "…Mediastinal Disorders: infrequent – nasal congestion, dyspnea Skin and Subcutaneous Tissue Disorders: infrequent – rash, hyperhidrosis, pruritus, photosensitivity reaction, alopecia; rare – urticaria Vascular Disorders: infrequent – hypotension, hypertension Pediatric Patients Most adverse events observed in…"

Risperdal · risperidone · Antipsychotic

Label: RISPERDAL / RISPERIDONE (prescription), effective May 28, 2026. Open on DailyMed · Our guide

Heat or temperature regulation · Warning · Warnings and precautions: "5.14 Body Temperature Regulation Disruption of body temperature regulation has been attributed to antipsychotic agents."
Overheating or heat stroke · Tied to heat or temperature regulation · Warnings and precautions: "Both hyperthermia and hypothermia have been reported in association with oral RISPERDAL use."
Sweating · Only as a symptom of neuroleptic malignant syndrome, a rare reaction · Warnings and precautions: "Clinical manifestations of NMS are hyperpyrexia, muscle rigidity, altered mental status including delirium, and autonomic instability (irregular pulse or blood pressure, tachycardia, diaphoresis, and cardiac dysrhythmia)."
Dehydration · Warning · Warnings and precautions: "…disease (history of myocardial infarction or ischemia, heart failure, or conduction abnormalities), cerebrovascular disease, and conditions which would predispose patients to hypotension, e.g., dehydration and hypovolemia, and in the elderly and patients with renal or hepatic impairment."
Dizziness on standing · Warning · Warnings and precautions: "( 5.6 ) Orthostatic hypotension: For patients at risk, consider a lower starting dose and slower titration."

Zyprexa · olanzapine · Antipsychotic

Label: Zyprexa / olanzapine (prescription), effective Mar 6, 2026. Open on DailyMed · Our guide

Heat or temperature regulation · Warning · Warnings and precautions: "5.13 Body Temperature Regulation Disruption of the body's ability to reduce core body temperature has been attributed to antipsychotic agents."
Overheating or heat stroke · Only as a symptom of neuroleptic malignant syndrome, a rare reaction · Warnings and precautions: "Clinical manifestations of NMS are hyperpyrexia, muscle rigidity, altered mental status and evidence of autonomic instability (irregular pulse or blood pressure, tachycardia, diaphoresis and cardiac dysrhythmia)."
Sweating · Side effect · Adverse reactions: "…5 2 Paresthesia 5 2 Apathy 4 3 Confusion 4 1 Euphoria 3 2 Incoordination 2 0 Respiratory System Pharyngitis 4 1 Dyspnea 3 1 Skin and Appendages Sweating 3 1 Acne 2 0 Dry skin 2 0 Special Senses Amblyopia 9 5 Abnormal vision 2 0 Urogenital System Dysmenorrhea a 2 0 Vaginitis a 2 0 For specific…"
Dehydration · Warning · Warnings and precautions: "…or ischemia, heart failure, or conduction abnormalities), cerebrovascular disease, and conditions which would predispose patients to hypotension (dehydration, hypovolemia, and treatment with antihypertensive medications) where the occurrence of syncope, or hypotension and/or bradycardia might put the…"
Dizziness on standing · Warning · Warnings and precautions: "( 5.6 ) Orthostatic Hypotension: Orthostatic hypotension associated with dizziness, tachycardia, bradycardia and, in some patients, syncope, may occur especially during initial dose titration."
Sun sensitivity · Side effect · Adverse reactions: "Body as a Whole — Infrequent: chills, face edema, photosensitivity reaction, suicide attempt 1 ; Rare: chills and fever, hangover effect, sudden death 1 ."

Seroquel · quetiapine · Antipsychotic

Label: SEROQUEL / QUETIAPINE (prescription), effective Apr 10, 2026. Open on DailyMed · Our guide

Heat or temperature regulation · Warning · Warnings and precautions: "5.17 Body Temperature Regulation Although not reported with SEROQUEL, disruption of the body's ability to reduce core body temperature has been attributed to antipsychotic agents."
Overheating or heat stroke · Side effect · Medication Guide: "SEROQUEL can cause serious side effects, including: … • increased body temperature"
Sweating · Side effect · Adverse reactions: "…2% 1% Increased Appetite 2% 1% Hypothyroidism 2% 1% Incoordination 2% 1% Thinking Abnormal 2% 0% Anxiety 2% 0% Ataxia 2% 0% Sinusitis 2% 1% Sweating 2% 1% Urinary Tract Infection 2% 1% In bipolar depression studies (up to 8 weeks), the most commonly observed adverse reactions associated with the…"
Dehydration · Warning · Warnings and precautions: "…(history of myocardial infarction or ischemic heart disease, heart failure, or conduction abnormalities), cerebrovascular disease or conditions which would predispose patients to hypotension (dehydration, hypovolemia, and treatment with antihypertensive medications)."
Dizziness on standing · Warning · Warnings and precautions: "5.7 Hypotension Quetiapine may induce orthostatic hypotension associated with dizziness, tachycardia and, in some patients, syncope, especially during the initial dose-titration period, probably reflecting its α 1 -adrenergic antagonist properties."

Seroquel XR · quetiapine, extended release · Antipsychotic

Label: SEROQUEL XR / QUETIAPINE (prescription), effective Apr 10, 2026. Open on DailyMed · Our guide

Heat or temperature regulation · Warning · Warnings and precautions: "5.17 Body Temperature Regulation Disruption of the body's ability to reduce core body temperature has been attributed to antipsychotic agents."
Overheating or heat stroke · Side effect · Medication Guide: "SEROQUEL XR can cause serious side effects, including: … • increased body temperature"
Sweating · Side effect · Adverse reactions: "…2% 1% Migraine 2% 1% Restless Legs Syndrome 2% 1% Anxiety 2% 1% Sinus Headache 2% 1% Libido Decreased 2% 1% Pollakiuria 2% 1% Sinus Congestion 2% 1% Hyperhidrosis 2% 1% Orthostatic Hypotension 2% 1% Urinary Tract Infection 2% 0% Heart Rate Increased 2% 0% Neck Pain 2% 0% Dysarthria 2% 0% Akathisia 2% 0%…"
Dehydration · Warning · Warnings and precautions: "…(history of myocardial infarction or ischemic heart disease, heart failure, or conduction abnormalities), cerebrovascular disease, or conditions which would predispose patients to hypotension (dehydration, hypovolemia, and treatment with antihypertensive medications)."
Dizziness on standing · Warning · Warnings and precautions: "5.7 Hypotension Quetiapine may induce orthostatic hypotension associated with dizziness, tachycardia and, in some patients, syncope, especially during the initial dose-titration period, probably reflecting its ά1-adrenergic antagonist properties."

haloperidol · haloperidol · Antipsychotic (first generation)

Label: Haloperidol / HALOPERIDOL (prescription), effective Aug 5, 2026. Open on DailyMed

Overheating or heat stroke · Warning · Warnings: "Hyperpyrexia and heat stroke, not associated with the above symptom complex, have also been reported with haloperidol."
Sweating · Side effect · Adverse reactions: "Autonomic Reactions Dry mouth, blurred vision, urinary retention, diaphoresis and priapism."
Dehydration · Warning · Warnings: "It has been postulated that lethargy and decreased sensation of thirst due to central inhibition may lead to dehydration, hemoconcentration and reduced pulmonary ventilation."
Dizziness on standing · Warning · Warnings: "Falls Haloperidol tablets may cause somnolence, postural hypotension, motor and sensory instability, which may lead to falls and, consequently, fractures or other injuries."
Sun sensitivity · Side effect · Adverse reactions: "Dermatologic Reactions Maculopapular and acneiform skin reactions and isolated cases of photosensitivity and loss of hair."

Clozaril · clozapine · Antipsychotic

Label: Clozaril / CLOZAPINE (prescription), effective Jun 6, 2025. Open on DailyMed

Overheating or heat stroke · Side effect · Adverse reactions: "…CLOZARIL (N=126) (%) Chlorpromazine (N=142) (%) Sedation 21 13 Tachycardia 17 11 Constipation 16 12 Dizziness 14 16 Hypotension 13 38 Fever (hyperthermia) 13 4 Hypersalivation 13 1 Hypertension 12 5 Headache 10 10 Nausea/vomiting 10 12 Dry mouth 5 20 Table 10 summarizes the adverse reactions reported…"
Sweating · Side effect · Adverse reactions: "…including sedation, dizziness/vertigo, headache, and tremor; cardiovascular reactions, including tachycardia, hypotension, and syncope; autonomic nervous system reactions, including hypersalivation, sweating, dry mouth, and visual disturbances; gastrointestinal reactions, including constipation and nausea; and fever."
Dehydration · Warning · Boxed warning: "Use CLOZARIL cautiously in patients with cardiovascular or cerebrovascular disease or conditions predisposing to hypotension (e.g., dehydration, use of antihypertensive medications) [see Dosage and Administration ( 2.2 , 2.6 ), Warnings and Precautions ( 5.2 )]."
Dizziness on standing · Warning · Boxed warning: "WARNING: SEVERE NEUTROPENIA; ORTHOSTATIC HYPOTENSION, BRADYCARDIA, AND SYNCOPE; SEIZURE; MYOCARDITIS, PERICARDITIS AND CARDIOMYOPATHY; INCREASED MORTALITY IN ELDERLY PATIENTS WITH DEMENTIA-RELATED PSYCHOSIS Severe Neutropenia CLOZARIL has caused…"
Sun sensitivity · Side effect · Adverse reactions: "Skin and Subcutaneous Tissue Disorders Hypersensitivity reactions: photosensitivity, vasculitis, erythema multiforme, skin pigmentation disorder, and Stevens-Johnson Syndrome."

Anticonvulsants

Topamax · topiramate · Anticonvulsant

Label: Topamax / TOPIRAMATE (prescription), effective Mar 12, 2026. Open on DailyMed · Our guide

Heat or temperature regulation · Warning · Warnings and precautions: "Patients (especially pediatric patients) treated with TOPAMAX should be monitored closely for evidence of decreased sweating and increased body temperature, especially in hot weather."
Reduced sweating · Warning · Warnings and precautions: "5.3 Oligohidrosis and Hyperthermia Oligohidrosis (decreased sweating), infrequently resulting in hospitalization, has been reported in association with TOPAMAX use. Decreased sweating and an elevation in body temperature above normal characterized these cases."
Overheating or heat stroke · Tied to heat or temperature regulation · Warnings and precautions: "5.3 Oligohidrosis and Hyperthermia Oligohidrosis (decreased sweating), infrequently resulting in hospitalization, has been reported in association with TOPAMAX use. Decreased sweating and an elevation in body temperature above normal characterized these cases."
Dizziness on standing · Side effect · Adverse reactions: "Other Adverse Reactions Observed During Clinical Trials Other adverse reactions seen during clinical trials were: abnormal coordination, eosinophilia, gingival bleeding, hematuria, hypotension, myalgia, myopia, postural hypotension, scotoma, suicide attempt, syncope, and visual field defect."

Qsymia · phentermine and topiramate · Weight-loss (topiramate combination)

Label: Qsymia / PHENTERMINE AND TOPIRAMATE (prescription), effective Apr 22, 2026. Open on DailyMed · Our guide

Heat or temperature regulation · Warning · Warnings and precautions: "Advise all patients and caregivers to monitor for decreased sweating and increased body temperature during physical activity, especially in hot weather."
Reduced sweating · Warning · Warnings and precautions: "5.11 Oligohidrosis and Hyperthermia Oligohidrosis (decreased sweating), infrequently resulting in hospitalization, has been reported in association with the use of topiramate."
Overheating or heat stroke · Tied to heat or temperature regulation · Warnings and precautions: "5.11 Oligohidrosis and Hyperthermia Oligohidrosis (decreased sweating), infrequently resulting in hospitalization, has been reported in association with the use of topiramate."

Zonisade · zonisamide · Anticonvulsant

Label: ZONISADE / ZONISAMIDE (prescription), effective Sep 8, 2025. Open on DailyMed · Our guide

Heat or temperature regulation · Warning · Warnings and precautions: "Patients, especially pediatric patients, treated with ZONISADE should be monitored closely for evidence of decreased sweating and increased body temperature, especially in warm or hot weather."
Reduced sweating · Warning · Warnings and precautions: "Oligohidrosis and Hyperthermia in Pediatric Patients: Oligohidrosis, sometimes resulting in heat stroke and hospitalization, is seen in association with zonisamide in pediatric patients ( 5.5 )."
Overheating or heat stroke · Tied to heat or temperature regulation · Warnings and precautions: "Oligohidrosis and Hyperthermia in Pediatric Patients: Oligohidrosis, sometimes resulting in heat stroke and hospitalization, is seen in association with zonisamide in pediatric patients ( 5.5 )."
Sweating · Side effect · Adverse reactions: "Infrequent: Maculopapular rash, acne, alopecia, dry skin, sweating, eczema, urticaria, hirsutism, pustular rash, vesiculobullous rash."
Dehydration · Side effect · Adverse reactions: "Metabolic and Nutritional : Infrequent: Peripheral edema, weight gain, edema, thirst, dehydration."

Lamictal · lamotrigine · Anticonvulsant / mood stabilizer

Label: LAMICTAL / LAMOTRIGINE (prescription), effective Oct 10, 2025. Open on DailyMed · Our guide

Sweating · Side effect · Adverse reactions: "Skin and Appendages: Contact dermatitis, dry skin, sweating."
Dizziness on standing · Side effect · Adverse reactions: "Cardiovascular System Infrequent: Flushing, hot flashes, hypertension, palpitations, postural hypotension, syncope, tachycardia, vasodilation."
Sun sensitivity · Side effect · Adverse reactions: "…171) Body as a whole Infection 20 17 Fever 15 14 Accidental injury 14 12 Abdominal pain 10 5 Asthenia 8 4 Flu syndrome 7 6 Pain 5 4 Facial edema 2 1 Photosensitivity 2 0 Cardiovascular Hemorrhage 2 1 Digestive Vomiting 20 16 Diarrhea 11 9 Nausea 10 2 Constipation 4 2 Dyspepsia 2 1 Hemic and lymphatic…"

Neurontin · gabapentin · Anticonvulsant / nerve pain

Label: Neurontin / GABAPENTIN (prescription), effective May 12, 2026. Open on DailyMed · Our guide

Sweating · Only on stopping the drug (withdrawal) · Adverse reactions: "There are postmarketing reports of withdrawal symptoms after discontinuation of gabapentin. Reported adverse reactions include, but are not limited to, seizures, depression, suicidal ideation and behavior, agitation, confusion, disorientation, psychotic symptoms, anxiety, insomnia, nausea, pain, sweating, tremor, headache, dizziness, and malaise [see Warnings and Precautions (5.6) ] ."

Sleep and anxiety

trazodone · trazodone · Antidepressant / sleep

Label: Trazodone Hydrochloride / TRAZODONE HYDROCHLORIDE (prescription), effective Sep 3, 2026. Open on DailyMed · Our guide

Overheating or heat stroke · Only as a symptom of serotonin syndrome, a rare reaction · Warnings and precautions: "…agitation, hallucinations, delirium, and coma), autonomic instability (e.g., tachycardia, labile blood pressure, dizziness, diaphoresis, flushing, hyperthermia), neuromuscular symptoms (e.g., tremor, rigidity, myoclonus, hyperreflexia, incoordination), seizures, and gastrointestinal symptoms (e.g., nausea,…"
Sweating · Only as a symptom of serotonin syndrome, a rare reaction · Warnings and precautions: "…status changes (e.g., agitation, hallucinations, delirium, and coma), autonomic instability (e.g., tachycardia, labile blood pressure, dizziness, diaphoresis, flushing, hyperthermia), neuromuscular symptoms (e.g., tremor, rigidity, myoclonus, hyperreflexia, incoordination), seizures, and gastrointestinal…"
Dizziness on standing · Warning · Warnings and precautions: "Orthostatic Hypotension and Syncope: Warn patients of risk and symptoms of hypotension ( 5.4 )."

Xanax · alprazolam · Benzodiazepine

Label: Xanax / ALPRAZOLAM (prescription), effective Apr 15, 2024. Open on DailyMed · Our guide

Sweating · Only on stopping the drug (withdrawal) · Adverse reactions: "…Decreased salivation 16.5% 13.6% 10.6% Metabolism and nutrition disorders Weight loss Decreased appetite 13.3% 12.8% Dermatological disorders Sweating 14.4% Cardiovascular disorders Tachycardia 12.2% Special Senses Blurred vision 10.0% There have also been reports of withdrawal seizures upon rapid…"
Sun sensitivity · Side effect · Adverse reactions: "…failure Investigations: Liver enzyme elevations Psychiatric disorders: Hypomania, mania Reproductive system and breast disorders: Gynecomastia, galactorrhea Skin and subcutaneous tissue disorders: Photosensitivity reaction, angioedema, Stevens-Johnson syndrome"

Ambien · zolpidem · Sleep medication

Label: Ambien / ZOLPIDEM TARTRATE (prescription), effective Apr 15, 2025. Open on DailyMed · Our guide

Sweating · Side effect · Adverse reactions: "Autonomic nervous system: Infrequent: increased sweating, pallor, postural hypotension, syncope."
Dizziness on standing · Side effect · Adverse reactions: "Autonomic nervous system: Infrequent: increased sweating, pallor, postural hypotension, syncope."
Sun sensitivity · Side effect · Adverse reactions: "Rare: acne, bullous eruption, dermatitis, furunculosis, injection-site inflammation, photosensitivity reaction, urticaria."

Anticholinergics and antihistamines

oxybutynin · oxybutynin · Anticholinergic (bladder)

Label: Oxybutynin Chloride / OXYBUTYNIN CHLORIDE (prescription), effective Jul 27, 2026. Open on DailyMed · Our guide

Heat or temperature regulation · Warning · Precautions: "Patients should be informed that heat prostration (fever and heat stroke due to decreased sweating) can occur when anticholinergics such as oxybutynin chloride are administered in the presence of high environmental temperature."
Reduced sweating · Warning · Precautions: "Patients should be informed that heat prostration (fever and heat stroke due to decreased sweating) can occur when anticholinergics such as oxybutynin chloride are administered in the presence of high environmental temperature."
Overheating or heat stroke · Tied to heat or temperature regulation · Precautions: "Patients should be informed that heat prostration (fever and heat stroke due to decreased sweating) can occur when anticholinergics such as oxybutynin chloride are administered in the presence of high environmental temperature."
Dehydration · Only in the overdose section · Overdosage: "Overdosage with oxybutynin chloride has been associated with anticholinergic effects including central nervous system excitation (e.g., restlessness, tremor, irritability, convulsions, delirium, hallucinations), flushing, fever, dehydration, cardiac arrhythmia, vomiting, and urinary retention."

benztropine · benztropine · Anticholinergic (Parkinson's / drug-induced movement)

Label: Benztropine Mesylate / BENZTROPINE MESYLATE (prescription), effective Jan 9, 2026. Open on DailyMed

Heat or temperature regulation · Warning · Warnings: "For this reason, it should be administered with caution during hot weather, especially when given concomitantly with other atropine-like drugs to the chronically ill, the alcoholic, those who have central nervous system disease, and those who do manual labor in a hot environment."
Reduced sweating · Warning · Warnings: "Since benztropine mesylate contains structural features of atropine, it may produce anhidrosis."
Overheating or heat stroke · Tied to heat or temperature regulation · Warnings: "If there is evidence of anhidrosis, the possibility of hyperthermia should be considered."

glycopyrrolate (oral) · glycopyrrolate · Anticholinergic

Label: Glycopyrrolate / GLYCOPYRROLATE (prescription), effective Feb 12, 2026. Open on DailyMed

Heat or temperature regulation · Warning · Warnings and precautions: "( 5.4 , 7.1 ) Heat Prostration at High Environmental Temperatures : Heat prostration resulting in fever and heatstroke can occur, especially in geriatric patients."
Reduced sweating · Warning · Warnings and precautions: "5.5 Heat Prostration at High Environmental Temperatures In the presence of a high environmental temperature, heat prostration resulting in fever and heatstroke can occur with the use of glycopyrrolate tablets due to decreased sweating, particularly in geriatric patients [see Adverse Reactions ( 6 )] ."
Overheating or heat stroke · Tied to heat or temperature regulation · Warnings and precautions: "( 5.4 , 7.1 ) Heat Prostration at High Environmental Temperatures : Heat prostration resulting in fever and heatstroke can occur, especially in geriatric patients."

hyoscyamine · hyoscyamine · Anticholinergic (gut, bladder)

Label: Hyoscyamine Sulfate / HYOSCYAMINE SULFATE (prescription), effective Jul 29, 2026. Open on DailyMed

Heat or temperature regulation · Warning · Warnings: "WARNINGS In the presence of high environmental temperature, heat prostration can occur with drug use (fever and heat stroke due to decreased sweating)."
Reduced sweating · Warning · Warnings: "WARNINGS In the presence of high environmental temperature, heat prostration can occur with drug use (fever and heat stroke due to decreased sweating)."
Overheating or heat stroke · Tied to heat or temperature regulation · Warnings: "WARNINGS In the presence of high environmental temperature, heat prostration can occur with drug use (fever and heat stroke due to decreased sweating)."

tolterodine (Detrol) · tolterodine · Antimuscarinic (bladder)

Label: Tolterodine Tartrate / TOLTERODINE TARTRATE (prescription), effective Apr 1, 2025. Open on DailyMed

This label uses none of the seven terms. That is not evidence the medicine is safe in heat; ask a pharmacist.

solifenacin (Vesicare) · solifenacin · Antimuscarinic (bladder)

Label: Solifenacin succinate / SOLIFENACIN SUCCINATE (prescription), effective Jul 6, 2026. Open on DailyMed

Heat or temperature regulation · Advice to patients · Patient counseling: "Heat prostration due to decreased sweating can occur when Solifenacin succinate tablets are used in a hot environment [see Adverse Reactions ( 6.2 )] ."
Reduced sweating · Advice to patients · Patient counseling: "Dry Skin Inform patients that Solifenacin succinate tablets, like other antimuscarinics, may cause dry skin due to decreased sweating."
Overheating or heat stroke · Tied to heat or temperature regulation · Patient information: "Heat exhaustion or heat stroke can happen due to decreased sweating when solifenacin succinate tablets are used in hot environments."

Benadryl · diphenhydramine · Antihistamine (sedating)

Label: Benadryl / DIPHENHYDRAMINE HYDROCHLORIDE (over the counter), effective Jul 28, 2026. Open on DailyMed · Our guide

This label uses none of the seven terms. That is not evidence the medicine is safe in heat; ask a pharmacist.

Unisom SleepTabs · doxylamine · Antihistamine (sedating)

Label: Unisom SleepTabs / DOXYLAMINE SUCCINATE (over the counter), effective Jan 14, 2026. Open on DailyMed · Our guide

This label uses none of the seven terms. That is not evidence the medicine is safe in heat; ask a pharmacist.

hydroxyzine · hydroxyzine · Antihistamine (sedating)

Label: Hydroxyzine Hydrochloride / HYDROXYZINE HYDROCHLORIDE (prescription), effective Mar 3, 2026. Open on DailyMed · Our guide

This label uses none of the seven terms. That is not evidence the medicine is safe in heat; ask a pharmacist.

Zyrtec · cetirizine · Antihistamine

Label: Zyrtec Allergy / CETIRIZINE HYDROCHLORIDE (over the counter), effective Oct 10, 2025. Open on DailyMed · Our guide

This label uses none of the seven terms. That is not evidence the medicine is safe in heat; ask a pharmacist.

Allegra-D · fexofenadine and pseudoephedrine · Antihistamine and decongestant

Label: Allegra-D Allergy and Congestion / FEXOFENADINE HYDROCHLORIDE AND PSEUDOEPHEDRINE HYDROCHLORIDE (over the counter), effective Jan 12, 2026. Open on DailyMed · Our guide

This label uses none of the seven terms. That is not evidence the medicine is safe in heat; ask a pharmacist.

Blood pressure and heart

Norvasc · amlodipine · Blood pressure (calcium channel blocker)

Label: Norvasc / AMLODIPINE BESYLATE (prescription), effective Feb 15, 2023. Open on DailyMed · Our guide

Sweating · Side effect · Adverse reactions: "Autonomic Nervous System: dry mouth, sweating increased."

Zestril · lisinopril · Blood pressure (ACE inhibitor)

Label: Zestril / LISINOPRIL (prescription), effective Jan 2, 2025. Open on DailyMed · Our guide

Sweating · Side effect · Adverse reactions: "Skin : Urticaria, alopecia, photosensitivity, erythema, flushing, diaphoresis, cutaneous pseudolymphoma, toxic epidermal necrolysis, Stevens - Johnson syndrome, and pruritus."
Dehydration · Warning · Warnings and precautions: "Patients whose renal function may depend in part on the activity of the renin-angiotensin system (e.g., patients with renal artery stenosis, chronic kidney disease, severe congestive heart failure, post-myocardial infarction or volume depletion) may be at particular risk of developing acute renal failure on Zestril."
Dizziness on standing · Side effect · Adverse reactions: "…with Zestril in controlled clinical trials and do not appear in other sections of labeling are listed below: Body as a whole : Fatigue, asthenia, orthostatic effects. Digestive : Pancreatitis, constipation, flatulence, dry mouth, diarrhea. Hematologic : Rare cases of bone marrow depression, hemolytic anemia,…"
Sun sensitivity · Side effect · Adverse reactions: "Skin : Urticaria, alopecia, photosensitivity, erythema, flushing, diaphoresis, cutaneous pseudolymphoma, toxic epidermal necrolysis, Stevens - Johnson syndrome, and pruritus."

Cozaar · losartan · Blood pressure (ARB)

Label: COZAAR / LOSARTAN POTASSIUM (prescription), effective Jan 20, 2026. Open on DailyMed · Our guide

Dehydration · Warning · Warnings and precautions: "Patients whose renal function may depend in part on the activity of the renin-angiotensin system (e.g., patients with renal artery stenosis, chronic kidney disease, severe congestive heart failure, or volume depletion) may be at particular risk of developing acute renal failure on COZAAR."
Dizziness on standing · Side effect · Adverse reactions: "placebo on a background of conventional antihypertensive therapy, were asthenia/fatigue, chest pain, hypotension, orthostatic hypotension, diarrhea, anemia, hyperkalemia, hypoglycemia, back pain, muscular weakness, and urinary tract infection."
Sun sensitivity · Side effect · Adverse reactions: "Skin and subcutaneous tissue disorders: Urticaria, pruritus, rash, photosensitivity."

Toprol-XL · metoprolol succinate · Blood pressure (beta blocker)

Label: TOPROL XL / METOPROLOL SUCCINATE (prescription), effective Mar 3, 2026. Open on DailyMed · Our guide

Sweating · Side effect · Adverse reactions: "Miscellaneous: Musculoskeletal pain, arthralgia, blurred vision, decreased libido, male impotence, tinnitus, reversible alopecia, agranulocytosis, dry eyes, worsening of psoriasis, Peyronie's disease, sweating, photosensitivity, taste disturbance."
Dizziness on standing · Only with certain other drugs · Drug interactions: "Observe patients treated with TOPROL-XL plus a catecholamine depletor for evidence of hypotension or marked bradycardia, which may produce vertigo, syncope, or postural hypotension."
Sun sensitivity · Side effect · Adverse reactions: "Miscellaneous: Musculoskeletal pain, arthralgia, blurred vision, decreased libido, male impotence, tinnitus, reversible alopecia, agranulocytosis, dry eyes, worsening of psoriasis, Peyronie's disease, sweating, photosensitivity, taste disturbance."

propranolol · propranolol · Beta blocker

Label: Propranolol Hydrochloride / PROPRANOLOL HYDROCHLORIDE (prescription), effective Jun 10, 2026. Open on DailyMed · Our guide

Dizziness on standing · Warning · Precautions: "Postural hypotension has been reported in patients taking both beta-blockers and terazosin or doxazosin."

hydrochlorothiazide · hydrochlorothiazide · Diuretic (thiazide)

Label: Hydrochlorothiazide / HYDROCHLOROTHIAZIDE (prescription), effective Jun 13, 2025. Open on DailyMed · Our guide

Heat or temperature regulation · Warning · Precautions: "Dilutional hyponatremia may occur in edematous patients in hot weather; appropriate therapy is water restriction, rather than administration of salt, except in rare instances when the hyponatremia is life threatening."
Dehydration · Only in the overdose section · Overdosage: "OVERDOSAGE The most common signs and symptoms observed are those caused by electrolyte depletion (hypokalemia, hypochloremia, hyponatremia) and dehydration resulting from excessive diuresis."
Dizziness on standing · Side effect · Adverse reactions: "Cardiovascular: Hypotension including orthostatic hypotension (may be aggravated by alcohol, barbiturates, narcotics or antihypertensive drugs)."
Sun sensitivity · Side effect · Adverse reactions: "Hypersensitivity: Anaphylactic reactions, necrotizing angiitis (vasculitis and cutaneous vasculitis), respiratory distress including pneumonitis and pulmonary edema, photosensitivity, fever, urticaria, rash, purpura."

Lasix · furosemide · Diuretic (loop)

Label: Lasix / FUROSEMIDE (prescription), effective Sep 30, 2025. Open on DailyMed · Our guide

Sweating · Only with certain other drugs · Precautions: "In isolated cases, intravenous administration of LASIX within 24 hours of taking chloral hydrate may lead to flushing, sweating attacks, restlessness, nausea, increase in blood pressure, and tachycardia."
Dehydration · Warning · Precautions: "PRECAUTIONS General Excessive diuresis may cause dehydration and blood volume reduction with circulatory collapse and possibly vascular thrombosis and embolism, particularly in elderly patients."
Dizziness on standing · Warning · Precautions: "The postural hypotension that sometimes occurs can usually be managed by getting up slowly."
Sun sensitivity · Warning · Precautions: "The skin of some patients may be more sensitive to the effects of sunlight while taking furosemide."

Aldactone · spironolactone · Diuretic (potassium-sparing)

Label: Aldactone / SPIRONOLACTONE (prescription), effective Nov 28, 2025. Open on DailyMed · Our guide

Dehydration · Warning · Warnings and precautions: "5.2 Hypotension and Worsening Renal Function Excessive diuresis may cause symptomatic dehydration, hypotension and worsening renal function, particularly in salt-depleted patients or those taking angiotensin converting enzyme inhibitors and angiotensin II receptor blockers."

clonidine (Catapres) · clonidine · Blood pressure (central)

Label: Clonidine hydrochloride / CLONIDINE HYDROCHLORIDE (prescription), effective Apr 30, 2026. Open on DailyMed · Our guide

Dizziness on standing · Warning · Precautions: "If a patient receiving clonidine is also taking neuroleptics, orthostatic regulation disturbances (e.g., orthostatic hypotension, dizziness, fatigue) may be induced or exacerbated."

Viagra · sildenafil · PDE5 inhibitor

Label: Viagra / SILDENAFIL CITRATE (prescription), effective Nov 17, 2023. Open on DailyMed · Our guide

Sweating · Side effect · Adverse reactions: "Skin and Appendages: urticaria, herpes simplex, pruritus, sweating, skin ulcer, contact dermatitis, exfoliative dermatitis."
Dehydration · Warning · Warnings and precautions: "Safety of combined use of PDE5 inhibitors and alpha-blockers may be affected by other variables, including intravascular volume depletion and other anti-hypertensive drugs."
Dizziness on standing · Side effect · Adverse reactions: "Cardiovascular: angina pectoris, AV block, migraine, syncope, tachycardia, palpitation, hypotension, postural hypotension, myocardial ischemia, cerebral thrombosis, cardiac arrest, heart failure, abnormal electrocardiogram, cardiomyopathy."
Sun sensitivity · Side effect · Adverse reactions: "Reported events include those with a plausible relation to drug use; omitted are minor events and reports too imprecise to be meaningful: Body as a Whole: face edema, photosensitivity reaction, shock, asthenia, pain, chills, accidental fall, abdominal pain, allergic reaction, chest pain, accidental injury."

Cialis · tadalafil · PDE5 inhibitor

Label: Cialis / TADALAFIL (prescription), effective Jun 3, 2026. Open on DailyMed · Our guide

Sweating · Side effect · Adverse reactions: "…somnolence, vertigo Renal and Urinary — renal impairment Respiratory — dyspnea, epistaxis, pharyngitis Skin and Appendages — pruritus, rash, sweating Ophthalmologic — blurred vision, changes in color vision, conjunctivitis (including conjunctival hyperemia), eye pain, lacrimation increase,…"
Dehydration · Warning · Warnings and precautions: "Safety of combined use of PDE5 inhibitors and alpha-blockers may be affected by other variables, including intravascular volume depletion and other antihypertensive drugs."
Dizziness on standing · Side effect · Adverse reactions: "…as a Whole — asthenia, face edema, fatigue, pain, peripheral edema Cardiovascular — angina pectoris, chest pain, hypotension, myocardial infarction, postural hypotension, palpitations, syncope, tachycardia Digestive — abnormal liver function tests, dry mouth, dysphagia, esophagitis, gastritis, GGTP increased, loose…"

Lipitor · atorvastatin · Statin

Label: Lipitor / ATORVASTATIN CALCIUM (prescription), effective Apr 15, 2024. Open on DailyMed · Our guide

This label uses none of the seven terms. That is not evidence the medicine is safe in heat; ask a pharmacist.

Blood thinners

Eliquis · apixaban · Anticoagulant

Label: Eliquis / apixaban (prescription), effective Jan 30, 2026. Open on DailyMed · Our guide

This label uses none of the seven terms. That is not evidence the medicine is safe in heat; ask a pharmacist.

Xarelto · rivaroxaban · Anticoagulant

Label: Xarelto / RIVAROXABAN (prescription), effective Sep 10, 2026. Open on DailyMed · Our guide

This label uses none of the seven terms. That is not evidence the medicine is safe in heat; ask a pharmacist.

warfarin · warfarin · Anticoagulant

Label: Jantoven / WARFARIN SODIUM (prescription), effective Jul 8, 2025. Open on DailyMed · Our guide

This label uses none of the seven terms. That is not evidence the medicine is safe in heat; ask a pharmacist.

Diabetes and weight

metformin · metformin · Diabetes

Label: Metformin Hydrochloride / METFORMIN HYDROCHLORIDE (prescription), effective Oct 28, 2025. Open on DailyMed · Our guide

Sweating · Side effect · Adverse reactions: "…tablets treated patients and were more commonly reported with metformin hydrochloride tablets than placebo: abnormal stools, hypoglycemia, myalgia, lightheaded, dyspnea, nail disorder, rash, sweating increased, taste disorder, chest discomfort, chills, flu syndrome, flushing, palpitation."
Dehydration · Warning · Warnings and precautions: "Surgery and other procedures — Withholding of food and fluids during surgical or other procedures may increase the risk for volume depletion, hypotension, and renal impairment."

Jardiance · empagliflozin · Diabetes / heart failure (SGLT2)

Label: Jardiance / EMPAGLIFLOZIN (prescription), effective Jan 30, 2026. Open on DailyMed · Our guide

Sweating · Only as a symptom of low blood sugar · Medication Guide: "Signs and symptoms of low blood sugar may include: headache drowsiness weakness irritability hunger fast heartbeat confusion shaking or feeling jittery dizziness sweating Amputations."
Dehydration · Warning · Warnings and precautions: "( 5.1 ) Volume Depletion: Before initiating JARDIANCE, assess volume status and renal function in patients with impaired renal function, elderly patients, or patients on loop diuretics."
Dizziness on standing · Advice to patients · Medication Guide: "Dehydration may cause you to feel dizzy, faint, light-headed, or weak, especially when you stand up (orthostatic hypotension)."

Farxiga · dapagliflozin · Diabetes / heart failure / kidney (SGLT2)

Label: FARXIGA / DAPAGLIFLOZIN (prescription), effective Jun 3, 2026. Open on DailyMed · Our guide

Sweating · Only as a symptom of low blood sugar · Medication Guide: "Signs and symptoms of low blood sugar may include: ∘ headache ∘ drowsiness ∘ weakness ∘ confusion ∘ dizziness ∘ sweating…"
Dehydration · Warning · Warnings and precautions: "Volume depletion: Before initiating FARXIGA, assess volume status and renal function in the elderly, patients with renal impairment or low systolic blood pressure, and in patients on diuretics."
Dizziness on standing · Advice to patients · Medication Guide: "Dehydration may cause you to feel dizzy, faint, lightheaded, or weak, especially when you stand up (orthostatic hypotension)."

Ozempic · semaglutide · GLP-1 (diabetes)

Label: Ozempic / semaglutide (prescription), effective Jun 1, 2026. Open on DailyMed · Our guide

Sweating · Only as a symptom of low blood sugar · Medication Guide: "Signs and symptoms of low blood sugar may include: o dizziness or light-headedness o blurred vision o anxiety, irritability, or mood changes o sweating o slurred speech o hunger o confusion or drowsiness o shakiness o weakness o headache o fast heartbeat o feeling jittery…"
Dehydration · Warning · Warnings and precautions: "Acute Kidney Injury Due to Volume Depletion: Monitor renal function in patients reporting adverse reactions that could lead to volume depletion."

Wegovy · semaglutide · GLP-1 (weight)

Label: Wegovy / semaglutide (prescription), effective Jun 18, 2026. Open on DailyMed · Our guide

Sweating · Only as a symptom of low blood sugar · Medication Guide: "Signs and symptoms of low blood sugar may include: o dizziness or light-headedness o sweating o shakiness o blurred vision o slurred speech o weakness o anxiety o hunger o headache o irritability or mood changes o confusion or drowsiness o fast heartbeat o feeling jittery…"
Dehydration · Warning · Warnings and precautions: "Acute Kidney Injury Due to Volume Depletion : Monitor renal function in patients reporting adverse reactions that could lead to volume depletion."
Dizziness on standing · Side effect · Adverse reactions: "Hypotension and Syncope Adverse reactions related to hypotension (hypotension, orthostatic hypotension, and decreased blood pressure) were reported in 1.3% of WEGOVY-treated adult patients versus 0.4% of placebo-treated patients and syncope was reported in 0.8% of WEGOVY-treated patients versus 0.2%…"

Mounjaro · tirzepatide · GLP-1/GIP (diabetes)

Label: Mounjaro / TIRZEPATIDE (prescription), effective Aug 27, 2026. Open on DailyMed · Our guide

Sweating · Only as a symptom of low blood sugar · Medication Guide: "Signs and symptoms of low blood sugar may include: dizziness or light-headedness sweating confusion or drowsiness headache blurred vision slurred speech shakiness fast heartbeat anxiety, irritability, or mood changes hunger weakness feeling jittery serious allergic reactions."
Dehydration · Warning · Warnings and precautions: "( 5.4 ) Acute Kidney Injury Due to Volume Depletion: Monitor renal function in patients reporting adverse reactions that could lead to volume depletion."

Zepbound · tirzepatide · GLP-1/GIP (weight)

Label: Zepbound / TIRZEPATIDE (prescription), effective Aug 28, 2026. Open on DailyMed · Our guide

Sweating · Only as a symptom of low blood sugar · Medication Guide: "Signs and symptoms of low blood sugar may include: dizziness or light-headedness sweating confusion or drowsiness headache blurred vision slurred speech shakiness fast heartbeat anxiety, irritability, or mood changes hunger weakness feeling jittery changes in vision in patients with type 2 diabetes."
Dehydration · Warning · Warnings and precautions: "( 5.2 ) Acute Kidney Injury Due to Volume Depletion: Monitor renal function in patients reporting adverse reactions that could lead to volume depletion."
Dizziness on standing · Side effect · Adverse reactions: "f Includes blood pressure decreased, hypotension, orthostatic hypotension."

Humalog · insulin lispro · Insulin

Label: Humalog / INSULIN LISPRO (prescription), effective Jun 16, 2026. Open on DailyMed · Our guide

Heat or temperature regulation · Advice to patients · Patient counseling: "Instruct patients to discard insulin exposed to temperatures higher than 98.6°F (37°C). The temperature of the insulin may exceed ambient temperature when the pump housing, cover, tubing or sport case is exposed to sunlight or radiant heat."
Sweating · Side effect · Adverse reactions: "Generalized allergy to insulin may cause whole body rash (including pruritus), dyspnea, wheezing, hypotension, tachycardia, or diaphoresis."

Synthroid · levothyroxine · Thyroid hormone

Label: Synthroid / LEVOTHYROXINE SODIUM (prescription), effective Feb 20, 2024. Open on DailyMed · Our guide

Heat or temperature regulation · As a sign of too much thyroid hormone · Adverse reactions: "Adverse reactions associated with SYNTHROID therapy are primarily those of hyperthyroidism due to therapeutic overdosage … General: fatigue, increased appetite, weight loss, heat intolerance, fever, excessive sweating"
Sweating · As a sign of too much thyroid hormone · Adverse reactions: "Adverse reactions associated with SYNTHROID therapy are primarily those of hyperthyroidism due to therapeutic overdosage … General: fatigue, increased appetite, weight loss, heat intolerance, fever, excessive sweating"

Skin, hair, hormones and antibiotics

Claravis · isotretinoin · Retinoid (oral, acne)

Label: Claravis / ISOTRETINOIN (prescription), effective Jul 22, 2026. Open on DailyMed · Our guide

Sweating · Side effect · Adverse reactions: "…reactions, pruritus, pyogenic granuloma, rash (including facial erythema, seborrhea, and eczema), skin fragility, Stevens-Johnson syndrome, sunburn, sweating, toxic epidermal necrolysis, urticaria, vasculitis (including granulomatosis with polyangiitis), wound healing abnormal (delayed healing or…"
Sun sensitivity · Advice to patients · Medication Guide: "Avoid sunlight and ultraviolet lights as much as possible. Tanning machines use ultraviolet lights. Claravis may make your skin more sensitive to light."

Retin-A Micro · tretinoin · Retinoid (topical)

Label: Retin-A MICRO / TRETINOIN (prescription), effective Sep 1, 2025. Open on DailyMed · Our guide

Sun sensitivity · Warning · Warnings and precautions: "Photosensitivity : RETIN-A MICRO can cause photosensitivity."

Tazorac · tazarotene · Retinoid (topical)

Label: TAZORAC / TAZAROTENE (prescription), effective Nov 13, 2025. Open on DailyMed · Our guide

Sun sensitivity · Warning · Warnings and precautions: "( 5.2 ) Photosensitivity and Risk for Sunburn: Avoid exposure to sunlight, sunlamps, and weather extremes."

Doryx MPC · doxycycline · Antibiotic (tetracycline)

Label: DORYX MPC / DOXYCYCLINE HYCLATE (prescription), effective Feb 16, 2026. Open on DailyMed · Our guide

Sun sensitivity · Warning · Warnings and precautions: "( 5.2 ) Photosensitivity manifested by an exaggerated sunburn reaction has been observed in some individuals taking tetracyclines."

ciprofloxacin · ciprofloxacin · Antibiotic (fluoroquinolone)

Label: Ciprofloxacin / CIPROFLOXACIN HYDROCHLORIDE (prescription), effective May 11, 2026. Open on DailyMed · Our guide

Sweating · Side effect · Adverse reactions: "…Dermatitis Toxic Epidermal Necrolysis Pruritus Urticaria Photosensitivity/Phototoxicity reaction Flushing Fever Angioedema Erythema Nodosum Sweating Special Senses Blurred Vision Disturbed Vision (chromatopsia and photopsia) Decreased Visual Acuity Diplopia Tinnitus Hearing Loss Bad Taste In…"
Sun sensitivity · Warning · Warnings and precautions: "5.14 Photosensitivity/Phototoxicity Moderate to severe photosensitivity/phototoxicity reactions, the latter of which may manifest as exaggerated sunburn reactions (for example, burning, erythema, exudation, vesicles,…"

minoxidil tablets · minoxidil (oral) · Blood pressure / hair loss (oral)

Label: Minoxidil / MINOXIDIL (prescription), effective Jun 11, 2026. Open on DailyMed · Our guide

Dizziness on standing · Warning · Boxed warning: "Patients with malignant hypertension and those already receiving guanethidine (see WARNINGS ) should be hospitalized when minoxidil is first administered so that they can be monitored to avoid too rapid, or large orthostatic, decreases in blood pressure."

Rogaine foam · minoxidil (topical) · Hair loss (topical)

Label: Mens rogaine Minoxidil Unscented Formula / MINOXIDIL (over the counter), effective Nov 11, 2024. Open on DailyMed · Our guide

This label uses none of the seven terms. That is not evidence the medicine is safe in heat; ask a pharmacist.

AndroGel 1.62% · testosterone gel · Testosterone

Label: AndroGel 1.62% / testosterone gel (prescription), effective Oct 22, 2025. Open on DailyMed · Our guide

This label uses none of the seven terms. That is not evidence the medicine is safe in heat; ask a pharmacist.

prednisone · prednisone · Corticosteroid

Label: Prednisone / PREDNISONE (prescription), effective Jul 31, 2026. Open on DailyMed · Our guide

Sweating · Side effect · Adverse reactions: "…edema, atrophy and thinning of skin, dry scaly skin, ecchymoses and petechiae (bruising), erythema, facial edema, hirsutism, impaired wound healing, increased sweating, Karposi’s sarcoma (see PRECAUTIONS: General Precautions ), lupus erythematosus-like lesions, perineal irritation, purpura, rash, striae,…"

Pain relievers

Celebrex · celecoxib · NSAID (prescription)

Label: CELEBREX / CELECOXIB (prescription), effective Nov 22, 2024. Open on DailyMed · Our guide

Sweating · Side effect · Adverse reactions: "…Skin and appendages: Alopecia, dermatitis, photosensitivity reaction, pruritus, rash erythematous, rash maculopapular, skin disorder, skin dry, sweating increased, urticaria Application site disorders: Cellulitis, dermatitis contact Urinary: Albuminuria, cystitis, dysuria, hematuria, micturition…"
Dehydration · Warning · Warnings and precautions: "Renal Toxicity : Monitor renal function in patients with renal or hepatic impairment, heart failure, dehydration, or hypovolemia."

Motrin IB · ibuprofen · NSAID (over the counter)

Label: Motrin IB / IBUPROFEN (over the counter), effective Oct 3, 2025. Open on DailyMed · Our guide

This label uses none of the seven terms. That is not evidence the medicine is safe in heat; ask a pharmacist.

Aleve · naproxen sodium · NSAID (over the counter)

Label: Aleve Caplets / NAPROXEN SODIUM (over the counter), effective Mar 12, 2026. Open on DailyMed · Our guide

This label uses none of the seven terms. That is not evidence the medicine is safe in heat; ask a pharmacist.

Skin patches

fentanyl transdermal system · fentanyl · Opioid patch

Label: FENTANYL / FENTANYL (prescription), effective Apr 7, 2026. Open on DailyMed · Our guide

Heat or temperature regulation · Warning · Boxed warning: "Warn patients to avoid exposing the fentanyl transdermal system application site and surrounding area to direct external heat sources."
Overheating or heat stroke · Tied to heat or temperature regulation · Warnings and precautions: "5.9 Risk of Increased Fentanyl Absorption with Elevated Body Temperature Based on a pharmacokinetic model, serum fentanyl concentrations could theoretically increase by approximately one-third for patients with a body temperature of 40°C (104°F) due to…"
Sweating · Side effect · Adverse reactions: "The most common adverse reactions (≥5%) in a double-blind, randomized, placebo-controlled clinical trial in patients with severe pain were nausea, vomiting, somnolence, dizziness, insomnia, constipation, hyperhidrosis, fatigue, feeling cold, and anorexia."
Dizziness on standing · Warning · Warnings and precautions: "5.14 Severe Hypotension Fentanyl transdermal system may cause severe hypotension including orthostatic hypotension and syncope in ambulatory patients."
Names a sauna or hot tub · Boxed warning: "…application site and surrounding area to direct external heat sources, such as heating pads or electric blankets, heat or tanning lamps, sunbathing, hot baths, saunas, hot tubs, and heated water beds may increase fentanyl absorption and has resulted in fatal overdose of fentanyl. Warn patients to avoid…"

Butrans · buprenorphine transdermal · Opioid patch

Label: Butrans / BUPRENORPHINE (prescription), effective May 1, 2026. Open on DailyMed · Our guide

Heat or temperature regulation · Warning · Warnings and precautions: "5.6 Risks of Use with Application of External Heat Advise patients and their caregivers to avoid exposing the BUTRANS application site and surrounding area to direct external heat sources, such as heating pads or electric blankets, heat or tanning…"
Sweating · Side effect · Adverse reactions: "…9% Somnolence 13% 4% Constipation 13% 5% Vomiting 9% 1% Application site erythema 7% 2% Application site rash 6% 6% Dry mouth 6% 2% Fatigue 5% 1% Hyperhidrosis 4% 1% Peripheral edema 3% 1% Pruritus 3% 0% Stomach discomfort 2% 0% The adverse reactions seen in controlled and open-label studies are presented…"
Dehydration · Side effect · Adverse reactions: "The most common serious adverse drug reactions (all <0.1%) occurring during clinical trials with BUTRANS were: chest pain, abdominal pain, vomiting, dehydration, and hypertension/blood pressure increased."
Dizziness on standing · Warning · Warnings and precautions: "5.12 Severe Hypotension BUTRANS may cause severe hypotension including orthostatic hypotension and syncope in ambulatory patients."
Names a sauna or hot tub · Warnings and precautions: "…the BUTRANS application site and surrounding area to direct external heat sources, such as heating pads or electric blankets, heat or tanning lamps, saunas, hot tubs, and heated water beds while wearing the system because an increase in absorption of buprenorphine may occur [see Clinical Pharmacology…"

NicoDerm CQ · nicotine transdermal · Nicotine patch

Label: NICODERM CQ / NICOTINE (over the counter), effective Jul 14, 2025. Open on DailyMed · Our guide

This label uses none of the seven terms. That is not evidence the medicine is safe in heat; ask a pharmacist.

Climara Pro · estradiol and levonorgestrel transdermal · Hormone patch (HRT)

Label: Climara Pro / ESTRADIOL AND LEVONORGESTREL (prescription), effective Mar 26, 2026. Open on DailyMed · Our guide

Heat or temperature regulation · Directions for use · Dosage and administration: "Swimming, bathing, or using a sauna while using Climara Pro has not been studied, and these activities may decrease the adhesion of the system and the delivery of the estrogen and progestin."

Xulane · norelgestromin and ethinyl estradiol transdermal · Contraceptive patch

Label: XULANE / NORELGESTROMIN AND ETHINYL ESTRADIOL (prescription), effective Mar 4, 2022. Open on DailyMed · Our guide

Heat or temperature regulation · Clinical pharmacology · Clinical pharmacology: "The absorption of NGMN and EE following application of norelgestromin and ethinyl estradiol transdermal system was studied under conditions encountered in a health club (sauna, whirlpool and treadmill) and in a cold water bath. The results indicated that for NGMN, there were no significant treatment effects on C ss or AUC when compared to normal wear. For EE, increased exposures were observed due to sauna, whirlpool and treadmill."
Sun sensitivity · Warning · Warnings and precautions: "Women with a tendency to chloasma should avoid exposure to the sun or ultraviolet radiation while using Xulane."

Transderm Scop · scopolamine transdermal · Anticholinergic patch (motion sickness)

Label: Transderm Scop / SCOPOLAMINE (prescription), effective Jun 10, 2025. Open on DailyMed

Heat or temperature regulation · Warning · Warnings and precautions: "Anticholinergic agents, including scopolamine, can increase core body temperature and reduce sweating, which may cause further increases in body temperature."
Reduced sweating · Warning · Warnings and precautions: "Anticholinergic agents, including scopolamine, can increase core body temperature and reduce sweating, which may cause further increases in body temperature."
Overheating or heat stroke · Tied to heat or temperature regulation · Warnings and precautions: "Hyperthermia may be exacerbated by exposure to external heat sources or high environmental temperature."
Sweating · Only on stopping the drug (withdrawal) · Warnings and precautions: "5.6 Drug Withdrawal/Post-Removal Symptoms Discontinuation of TRANSDERM SCŌP, usually after several days of use, may result in withdrawal symptoms, such as disturbances of equilibrium, dizziness, nausea, vomiting, abdominal cramps, sweating, headache, mental confusion, muscle weakness, bradycardia and hypotension."

Other

dronabinol · dronabinol · Cannabinoid (prescription)

Label: Dronabinol / DRONABINOL (prescription), effective May 6, 2026. Open on DailyMed · Our guide

Sweating · Side effect · Adverse reactions: "…Myalgias Central Nervous System Depression, nightmares, speech difficulties, tinnitus Respiratory Cough, rhinitis, sinusitis Skin Flushing, sweating Sensory Vision difficulties 6.2 Postmarketing Experience The following adverse reactions have been identified during post-approval use of dronabinol…"
Dehydration · Warning · Warnings and precautions: "In some cases, these adverse reactions were severe (e.g., dehydration, electrolyte abnormalities) and required dose reduction or drug discontinuation."
Dizziness on standing · Clinical pharmacology · Clinical pharmacology: "Its effects on blood pressure are inconsistent, but subjects have experienced orthostatic hypotension and/or syncope upon abrupt standing [see Warnings and Precautions ( 5.2 )]."

Questions people ask

Which medications can make heat harder to handle?

Of the 83 FDA drug labels in this index, 24 use heat language: hot weather, heat sources, high environmental temperatures, saunas and hot tubs, or the body's temperature regulation. Most fall into four groups: drugs that reduce sweating (Topamax, Qsymia, Zonisade, oxybutynin, benztropine, glycopyrrolate (oral), hyoscyamine, solifenacin (Vesicare) and Transderm Scop), antipsychotics with a warning on body temperature regulation (Abilify, Risperdal, Zyprexa, Seroquel and Seroquel XR), skin patches whose labels say to keep heat off the patch (Daytrana, fentanyl transdermal system and Butrans), and labels that name hot weather (amitriptyline, lithium carbonate and hydrochlorothiazide). Ask a pharmacist how your own medicines fit.

Which medications reduce sweating?

In this index, 9 labels say the drug can reduce sweating: Topamax, Qsymia, Zonisade, oxybutynin, benztropine, glycopyrrolate (oral), hyoscyamine, solifenacin (Vesicare) and Transderm Scop. All of them tie it to overheating, heat stroke or heat prostration, usually in hot conditions.

Do any medication labels mention saunas or hot tubs?

Only 4 of the 83, and all 4 are skin patches: the fentanyl patch, Butrans, Climara Pro and Xulane. The fentanyl and Butrans labels say to keep heat sources such as saunas and hot tubs away from the patch because heat can raise the amount of drug absorbed. The Climara Pro label says sauna use has not been studied and may loosen the patch and reduce the hormones it delivers. The Xulane label reports higher estrogen exposure with sauna, whirlpool and treadmill use.

Do antidepressants make you overheat?

None of the five SSRI and SNRI labels here (Zoloft, Lexapro, Prozac, Effexor XR and Cymbalta) carries a heat or hot-weather warning. Each mentions hyperthermia only as a symptom of serotonin syndrome, a rare drug reaction, and each lists sweating as a side effect. The older antidepressant amitriptyline is different: its label reports hyperpyrexia when it is taken with anticholinergic or neuroleptic drugs, particularly in hot weather.

Which psychiatric medications affect heat tolerance?

The labels for Abilify, Risperdal, Zyprexa, Seroquel and Seroquel XR carry a warning that antipsychotic drugs can disrupt the body's temperature regulation. The lithium label tells patients to avoid becoming overheated or dehydrated during exercise and in hot weather. The haloperidol label reports hyperpyrexia and heat stroke, and the amitriptyline label reports hyperpyrexia with certain other drugs in hot weather.

Which blood pressure medications affect how you handle heat?

Of the 10 blood pressure and diuretic labels here, 8 mention a drop in blood pressure when you stand up and 5 mention dehydration or volume depletion. Only hydrochlorothiazide names hot weather, in a warning about low sodium in people with edema. None of them names saunas or hot tubs.

Does a blank in this index mean a medication is safe in a sauna?

No. A blank means only that the label version we checked does not use the terms we searched for. Labels are written for prescribers and differ in age and length, and over-the-counter Drug Facts labels are brief: all 8 over-the-counter labels here use none of the seven terms. Ask a pharmacist about your own medicines, and never change a prescribed dose for a sauna session.

How can I cite or download this data?

The index is free to use under CC BY 4.0. Download it as CSV or JSON from this page or from its permanent archive on Zenodo, and cite it as: Tendground (2026), Medication heat-warning label index, version 1.0, FDA labels checked October 4, 2026, Zenodo, https://doi.org/10.5281/zenodo.23144104, with a link to this page.

To look up only your own medicines, use the medication and heat checker, which also shows whether the CDC's 2025 guidance lists each one. For what to do with this before a session, use our printable medication and heat checklist and the guide to medications, saunas and cold plunges.

How we built this index

Which medicines. 83 medicines in 13 groups: the drugs our medication guides cover, plus common drugs in the same classes, such as anticholinergic bladder and stomach medicines and the older antipsychotics.

Which label. For each medicine we took one label from the FDA drug label data published through openFDA, which mirrors the Structured Product Labeling on DailyMed: the most recently updated label for the exact product, from the manufacturer or brand owner rather than a repackager where one was available, and for generic drugs the immediate-release tablet where one exists. In one case, Celebrex, the newest label was a repackager's, so we used the brand owner's. Each row records the label's set ID, version and effective date.

What we searched. The full label text, except storage, packaging, product description, ingredient lists and clinical study sections, for the terms in each category (the exact patterns are in the JSON file). A term preceded closely by "no", "not" or "without" does not count. Mentions of reduced sweating never count as sweating, and a label describing the condition it treats (hot flashes, for example) does not count.

Which quote. For each category we show the single strongest statement in the label: a warning, a listed side effect or advice to patients comes before a mention that appears only as a symptom of a rare reaction, of overdose, of withdrawal, or with another drug. Quotes are verbatim. We read every one, corrected the matching rules where a reading showed a false match, and set a handful by hand; those are listed in the JSON file's notes.

What this index is not. It is not a list of medicines that are unsafe in a sauna, and it is not medical advice. It records what labels say in the words we searched for: a label can describe a risk in other words, labels differ in age and detail, over-the-counter labels are short, and a generic label can differ slightly from the brand's. Labels change, so check the DailyMed link for the current version. We are not clinicians. Talk to your pharmacist or prescriber about your own medicines, and never change a prescribed dose for a sauna session. Corrections are logged on our editorial standards page.

Data dictionary

Column	Meaning
drug, generic, drug_class, group	The medicine as we name it, its generic name, its class and the display group.
label_title, label_type	The label's brand and generic names as openFDA lists them; Rx or OTC.
set_id, label_version, label_effective, dailymed_url	The label's DailyMed set ID, version number and effective date, and its DailyMed page.
<category>	true if the label uses one of the category's terms. Categories: heat_or_thermoregulation, decreased_sweating, hyperthermia, sweating, dehydration, orthostatic_hypotension, photosensitivity.
<category>_direct	true if the quoted statement is direct; false if the term appears only as a symptom of a rare reaction, of overdose, of withdrawal, of too much thyroid hormone, or with another drug.
<category>_context, _section, _excerpt	The kind of statement, the label section it comes from, and the verbatim quote ("…" marks omitted text).
heat_kind	Our grouping of the heat statement: patch_heat, less_sweating, thermoregulation, hot_weather, drug_or_device, heat_intolerance.
names_sauna_or_hot_tub, sauna_excerpt	Whether the label names a sauna, hot tub, whirlpool or hot bath anywhere, with the first such sentence.
tendground_guide, checked	Our guide to the medicine, where we have one, and the date the labels were checked.

Citing this index?

You are welcome to use any figure or quote on this page. Please link to tendground.com/wellness/medication-heat-label-index so readers can see the method and the label dates. The full data is free under CC BY 4.0 as CSV or JSON.

Suggested citation:

Tendground. (2026). Medication heat-warning label index (Version 1.0) [Data set]. Zenodo. https://doi.org/10.5281/zenodo.23144104

A permanent copy with its own DOI is archived on Zenodo: 10.5281/zenodo.23144104. FDA drug labels checked October 4, 2026.

@misc{tendground_heat_label_index_2026,
  author       = {{Tendground}},
  title        = {Medication Heat-Warning Label Index},
  year         = {2026},
  version      = {1.0},
  publisher    = {Zenodo},
  doi          = {10.5281/zenodo.23144104},
  howpublished = {\url{https://www.tendground.com/wellness/medication-heat-label-index}},
  note         = {Data set, CC BY 4.0. FDA drug labels checked 2026-10-04}
}

Use this chart

Free to embed or republish under CC BY 4.0. The source line is part of the image; please keep the link to this page with it.

Bar chart: of 83 FDA drug labels, 33 mention dizziness on standing, 28 mention dehydration, 31 mention overheating or heat stroke, 27 mention sun sensitivity, 24 mention heat or temperature regulation, 9 mention reduced sweating; only 4 name saunas or hot tubs. Tendground label index.

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<a href="https://www.tendground.com/wellness/medication-heat-label-index"><img src="https://www.tendground.com/data/charts/medication-heat-label-index.svg" alt="Bar chart: of 83 FDA drug labels, 33 mention dizziness on standing, 28 mention dehydration, 31 mention overheating or heat stroke, 27 mention sun sensitivity, 24 mention heat or temperature regulation, 9 mention reduced sweating; only 4 name saunas or hot tubs. Tendground label index." width="720" height="524" style="max-width:100%;height:auto"></a>
<p>Source: <a href="https://www.tendground.com/wellness/medication-heat-label-index">Tendground medication heat-warning label index</a> (CC BY 4.0)</p>